Basic Information

Insect: Drosophila lowei
Gene Symbol: zfh1
Assembly: GCA_008121275.1
Location: CM017777.1:46821474-46846146[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00069 0.052 13.9 1.2 2 23 75 97 74 97 0.95

2 9 0.0017 0.13 12.6 0.1 1 23 301 323 301 323 0.96

3 9 9.5e-05 0.0071 16.6 1.7 2 23 338 359 337 359 0.97

4 9 4.7e-06 0.00035 20.7 6.3 1 23 368 390 368 390 0.99

5 9 0.00028 0.021 15.2 1.2 3 21 398 416 396 417 0.94

6 9 0.0078 0.58 10.6 1.8 2 21 663 682 662 683 0.92

7 9 1.2e-05 0.00092 19.4 0.5 1 23 1047 1069 1047 1069 0.94

8 9 4.6e-05 0.0034 17.6 7.4 1 23 1075 1097 1075 1097 0.98

9 9 0.0023 0.17 12.3 4.3 1 21 1103 1123 1103 1124 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00069	0.052	13.9	1.2	2	23	75	97	74	97	0.95
2	9	0.0017	0.13	12.6	0.1	1	23	301	323	301	323	0.96
3	9	9.5e-05	0.0071	16.6	1.7	2	23	338	359	337	359	0.97
4	9	4.7e-06	0.00035	20.7	6.3	1	23	368	390	368	390	0.99
5	9	0.00028	0.021	15.2	1.2	3	21	398	416	396	417	0.94
6	9	0.0078	0.58	10.6	1.8	2	21	663	682	662	683	0.92
7	9	1.2e-05	0.00092	19.4	0.5	1	23	1047	1069	1047	1069	0.94
8	9	4.6e-05	0.0034	17.6	7.4	1	23	1075	1097	1075	1097	0.98
9	9	0.0023	0.17	12.3	4.3	1	21	1103	1123	1103	1124	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTTCACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACAATGCAGTTTCCCTCTCTGGCTTCCAGTCTGCACCACCACCAGGCACCGCACAGCAAGGCGAGCAACGGCTCCGGGGGCAGCCAGGAGCAGCACGCCCAGCCAGGTGTCTCCGTCGATGATTTCCTGGTCAAGTGCCCGCAGTGCCACAAACGCTTTACAGAGTTTCAGTCCCTCAGCGAACACATTGCCAGCGAGCATCCGCACGATAAGCTGAACTTTGAGGCAAGCCGGGGCTCCAGCGGCGCCGTGCAGCCGGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGATACGCCAAGTCCCCTGCAACCACCGCCGCCACCCATGCCAcgcccagcaacaacaacaacagcgatcTGGCCAagaaccacaacaacaacaacaacaacagcagtaaGCTCTCTCCCATGTGCTCTCCGGGATCGGGGGGTcccgccaccaccgccgcagCAGATCTCTTCGCCCACCTCTCGCACGGAGCCCCGCCCCAGCTGCCCTCCCACCTGCACGCCCAGTTcatggccgccgccgccctgGCCATGCAGTCGGCCCGCTCCGTCAGCTCCTCCGCCAGTTCGCCCaacagccaccaccaccaccaccaccagcagcagtcgcaccaccacctccaacagcagcaccagcagcagctccaccagcagtcgcagcagctgctgccgccacaGCTACcgggcagcaacagcagcgtgGGCAGCAATTCCGCCTACGATCTGGACCTGAGTGCCCCGCGGTCCACCTCCAGTCCGGGCTCCACCACCGGCGACCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCGCGAACAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACCGGGGGCCAGCCTACGGCACAGAATGTCTCTCAGACTTGCCGAATCTGCCACAAAGCCTTCGCGAATGTCTACCGCCTGCAGCGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGCAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAATTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCTGGCGCCGGGCCCCGACGCTCGCCCACGAACCTGCAGGGCCCCAAAAACGGTGCCGGAAAGTTGTCCGACCAACAGTCCCTGCCTCCGCTGCCCAATCCTATGATCTACTTTGCCGGCGAGGCACAGGCGCAGGCTGCGGCCCCGAATGGAGCTCCTCCGCCGTTCTATCCCAACTACATGAATGCGGCCCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGATCCCCGCGTCCATCCCTACAGCATACAGCGGCTCCTGGAGCTGACGGCCGCcggacagcagcaacaacagcagcagcagcaacaacgcgAGGAACGcgaagagcaggagcagcacgAAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTCATGGACATCGACGAGGCTGAGGCCAAGGAGCGTATGGTGCCACAGGCGAGCCCTCAGACCATGCCAGAGGAGATCGAACCCGTTGTCGACATGGCCACTGCTCCCATCAAGCAGGAGCCCAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGGCCTCGCCCAAGTCCTtcaagcaggagcaggaggagcccCGTTCCGTGGAGGAGGATCAGCCCATGGAATCGGCTCAGCCCGAAGCCTCTGCCTCCTCCCCCAGGAGGGACACACCCGCCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAACCACCACACGGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATcaaggaggagctggagcagcactaccaccagcagcagcagcaacaacagcaccaccaacagcttcagcagcagcagcagcagcatcaccagcagGCATCCTTTGCCCTGCCCTCTGCCAGCGAGGatgacgacgaggaggaggagcgcgAGAACGACAACGACACGGAGCCACGTCCAGACAGCAACGAGCGCAAGGTGCGCGTGCGCACGGCCATCaacgaggagcagcagcagcagctgaagcagCACTACGCCCTGAATGCGCGGCCGAGTCGCGACGAGTTCCGGATGATTGCGGCCCGCCTCCAGCTGGATCCACGCGTGGTCCAGGTCTGGTTCCAGAACAATCGGTCACGCGAGCGCAAGATGCAGAGCTATGCGAGTGTCCACACGGCAGCTCCAGCCGCCAATGAAGTGCCCACCACTCCAGTGGCCAGCCGTCCCACTACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCCTGACGCCCAAGAGCGACCACTCCGCCGCGTACGGTTTGCCCCAGCAGCAGGCTGCCGGACAGCCAGGCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCACTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAATCCtcggcagctgcagccgccgcagcagcagctctctGGCCCTTTGGCGGCCCTCCTCCTTCGCCGCCCAGCCAGCTCGAGGTCACGCCCGCCCAGCACTGCTCGACGCCGCGAGGCGGACAGGCGTTCCCCGGACTCCAGTACATGCTGCCCATGCAGCGGCTCCCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTTCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCCTGATGCCGCCAAAGCCACGTCGCGGCAAGGCCGAGACCCACGGGCATGCCGGCGATCCGGATCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTTGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGTCTGCACAGCGGGGAGAAGCCCTTCCAGTGCTCCAAGTGCCTGAAGCGCTTCTCGCATTCGGGGAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKASNGSGGSQEQHAQPGVSVDDFLVKCPQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPATTAATHATPSNNNNSDLAKNHNNNNNNSSKLSPMCSPGSGGPATTAAADLFAHLSHGAPPQLPSHLHAQFMAAAALAMQSARSVSSSASSPNSHHHHHHQQQSHHHLQQQHQQQLHQQSQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAGPRRSPTNLQGPKNGAGKLSDQQSLPPLPNPMIYFAGEAQAQAAAPNGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQQQQQQQREEREEQEQHEEPETPEEPKLVMDIDEAEAKERMVPQASPQTMPEEIEPVVDMATAPIKQEPSREPTPLPESAPASPKSFKQEQEEPRSVEEDQPMESAQPEASASSPRRDTPAELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHHQQLQQQQQQHHQQASFALPSASEDDDEEEERENDNDTEPRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYASVHTAAPAANEVPTTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAAYGLPQQQAAGQPGPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQLEVTPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00535942;