Basic Information

Insect: Drosophila lowei
Gene Symbol: topi
Assembly: GCA_008121275.1
Location: CM017777.1:39814368-39817058[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 5.8 4.3e+02 1.6 2.0 1 19 146 163 146 166 0.74

2 11 4.8e-06 0.00035 20.7 0.5 2 23 246 267 246 267 0.97

3 11 0.0004 0.03 14.7 0.1 2 23 294 315 293 315 0.97

4 11 0.064 4.8 7.7 0.0 2 23 378 399 377 399 0.90

5 11 0.00019 0.014 15.7 0.5 1 21 446 466 446 470 0.90

6 11 0.01 0.76 10.2 0.7 2 23 485 507 484 507 0.90

7 11 7.6e-07 5.6e-05 23.2 1.9 1 23 532 554 532 554 0.95

8 11 0.0017 0.13 12.7 1.0 1 23 560 585 560 585 0.94

9 11 0.37 28 5.3 1.7 1 23 591 613 591 613 0.88

10 11 3.2e-08 2.4e-06 27.5 0.4 1 23 619 641 619 641 0.99

11 11 0.0014 0.11 12.9 2.0 1 23 647 670 647 670 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	5.8	4.3e+02	1.6	2.0	1	19	146	163	146	166	0.74
2	11	4.8e-06	0.00035	20.7	0.5	2	23	246	267	246	267	0.97
3	11	0.0004	0.03	14.7	0.1	2	23	294	315	293	315	0.97
4	11	0.064	4.8	7.7	0.0	2	23	378	399	377	399	0.90
5	11	0.00019	0.014	15.7	0.5	1	21	446	466	446	470	0.90
6	11	0.01	0.76	10.2	0.7	2	23	485	507	484	507	0.90
7	11	7.6e-07	5.6e-05	23.2	1.9	1	23	532	554	532	554	0.95
8	11	0.0017	0.13	12.7	1.0	1	23	560	585	560	585	0.94
9	11	0.37	28	5.3	1.7	1	23	591	613	591	613	0.88
10	11	3.2e-08	2.4e-06	27.5	0.4	1	23	619	641	619	641	0.99
11	11	0.0014	0.11	12.9	2.0	1	23	647	670	647	670	0.96

Sequence Information

Coding Sequence: ATGGGTGACGAGAATTTTGGGAGCTTTGAGCACAACGAGGTGGTGCCCGGTGAGTATACGCTGGCGGAGATTGAAGTTGGCGATGAGTCGCAGCTGAATTTCACCCACCTGCCAGGTGCCACAGTCCTGGCATCCAGCGAGGGGTACAGCCAAGTGCAGCGAATTCTCGGTCAGGAGGAACTGGTCCAGTTCTTTACCAGGCCACCGCCACCTATCATCCAGATGTCCACTGAGGTGGTTCTTCAGCGCACTCTGGAGCATCCAGCGCTGAAGCAGATACTCCAGGAAGCCGACGGCCAGCCAGATTTTGATCCGGCAGCAGAACAAATGAAAATACGCGAATTCTTGGCTGGCGTCACCAACAGTAAGATGACCACAGAGGAGTCGGTCTTTCAAGCACAACGCATGAGCATGGCATCGACTGGGTCCCGCATCTACAAGTGCCGTCACTGCGGTGGCAAGTACGACGCTGTGTACTTTTCCGGTCACATTTGTTTGTGCGAAGACGTCGCAAAACCCGTCTATGAGGCAGTCGGACATCAGGATAAGCCACGAGCAGTGAAGACGTCGACGGAAATGGGAACGGTCCCGGCGCCACGTTATGTTCGTGACACCGAGCGCATCATCTTGGAAAATCAAGTACGCCTACGCCGCTACATGAAGGACGAACTGAAGTACGATGTCACCACGGGCGTGGACAGTTCGCTGGCCAGGAAGACGGGCAAGCAGCTCAACGAGTGCAGTATATGCGATCGGCAGTTCGTGCATCCCTCCGGCCTGGTGCGCCACATGGAGAAGCATGCCCTGAACCTGATCGCCCCACAGGCCAATGCGCCATCAAACCCGGCTCCGCCTGCCCCCGGCCTGGCCGTAGTGATAAAGTGCAACGACTGTGGCCGTATCTTCTATGACAGCAAGCTGGCCATGGAGCATGCCCGTGTCCATTATCCCGAACAACCGAAGTTGACGACTGAGAACGAATCCGAAAAGAAAGATTTCTGTAAGCGTATGCTGAAGGGGGACTGGCTTTTCTTGTGTGTGCAGTCAAAGAAACGGAGCGTCGATCAGAAGCAAGAAAAGCGAGCGTTTGAGACCGGGCTATCTAGCACCCTGATCCTCGGTAGCGTGCTGCAATGCGAGTTCTGCGAGTACGTATTTGCGGATATTGAGAAGCTCCTAGTCCACTCGGCCGCTCACGTGGTGGAGAGGCGCTTCGAGTGCACCGCCTGTGGCATTACGATGAACACGGCCAAAGAGGCCAGTGTCCATTTCCAGACGGAATGCATCTTCATGCGCGAGGAACTCAAGCGGCTGGATGTCTCTCTGTTTCGATACTTTGTATGCAATGTGTGCGAGCAGAAGTTCTCCACCGCAGACCTGCTGCAGGAGCACCGATACATCTACTACCATTACTTTCCACGCCTCACCGCCGAAGGCAGTaacctgctgctgccctgcgAGTATTGCGATGCCAACTTCACGCATGCCCACGAGGTGGAGGCGCATAACCAGGAGAAGCATCTGAACAAGAAGAGGCGCGAAAAGGAGACGCGCACCAACGGCCCCAGCTACGGCAACGGCCGCCTTCGCCAGTACCTCTGCGACGTCTGTGGAAAGTCGTACACTCAGTCCAGCCATCTGTGGCAGCACTTGCGCTTCCACCAGGGTGTCAAGCCCTTCGCCTGCCAAGAGGCCAATTGCGATAGGAAGTTCACCATCCGTCCGGACCTCAACGATCACATCCGCAAGTGCCATACTGGAGAGCGACCGTATCATTGCCTGGTGTGTGGAAAGCGCTTCCTCACCGGTTCCGTCTTCTATCAGCACCGTCTTATACATCGCGGGGAGCGGCGCTACGAGTGCGATGAATGCGGCAAGCGGTTCTACCGAGCCGATGCCCTGAAGAACCACCAGAGGATCCACACTGGCGAGAAACCATATAGCTGCCTCTTCTGCACGAAGACATTTCGCCAGCGCGGAGACCGGGACAAGCATATACGTGCACGACATTCCCATTTGGACGCCAACTCTCGTCTTATGATGCAGATGCAGAAGTTCCAGCTGGAGTCGGCGCAAGCAGCAAAGGCCAGAATCCGGCAGGAACAAATGGGCGACGGTGACAGCTACTCGGCGGAAGCATCAGGATCTCATGTCGGTCCTGAGGAAGATGGTCCAAACAACTTCGTTACGGAAGAACAAGACGGAATGTATTGCGATCCAATAGATGGATTCACTTCAAACCAATTTGAGATTCAGCAGTGTGTGGAGGAGGCGGAGCCCACACCCATGAATGAAGACGTAGATCAAGAAATAATTGTGTACGAGAGCCCAGAGCCGACTATGACAGTGTCTTATGAACCAAAGCCAGAACCACAGCAAATAAAACAGGAGATTCCAGTGAAACCTGAAAGACCAAAGCGTAAAATTGTGGTGGTGAAGAATAATCCATCTCTACCGTTTTATGCAAATTCGTACATGTAA
Protein Sequence: MGDENFGSFEHNEVVPGEYTLAEIEVGDESQLNFTHLPGATVLASSEGYSQVQRILGQEELVQFFTRPPPPIIQMSTEVVLQRTLEHPALKQILQEADGQPDFDPAAEQMKIREFLAGVTNSKMTTEESVFQAQRMSMASTGSRIYKCRHCGGKYDAVYFSGHICLCEDVAKPVYEAVGHQDKPRAVKTSTEMGTVPAPRYVRDTERIILENQVRLRRYMKDELKYDVTTGVDSSLARKTGKQLNECSICDRQFVHPSGLVRHMEKHALNLIAPQANAPSNPAPPAPGLAVVIKCNDCGRIFYDSKLAMEHARVHYPEQPKLTTENESEKKDFCKRMLKGDWLFLCVQSKKRSVDQKQEKRAFETGLSSTLILGSVLQCEFCEYVFADIEKLLVHSAAHVVERRFECTACGITMNTAKEASVHFQTECIFMREELKRLDVSLFRYFVCNVCEQKFSTADLLQEHRYIYYHYFPRLTAEGSNLLLPCEYCDANFTHAHEVEAHNQEKHLNKKRREKETRTNGPSYGNGRLRQYLCDVCGKSYTQSSHLWQHLRFHQGVKPFACQEANCDRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAQAAKARIRQEQMGDGDSYSAEASGSHVGPEEDGPNNFVTEEQDGMYCDPIDGFTSNQFEIQQCVEEAEPTPMNEDVDQEIIVYESPEPTMTVSYEPKPEPQQIKQEIPVKPERPKRKIVVVKNNPSLPFYANSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00611511;
90% Identity: iTF_00580947;
80% Identity: -