Basic Information

Gene Symbol
HIVEP2
Assembly
GCA_008042735.1
Location
VNKB01004787.1:21000-29107[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.00023 0.02 15.4 0.2 1 23 246 268 246 268 0.98
2 8 0.00023 0.02 15.4 2.9 1 21 274 294 274 298 0.89
3 8 0.028 2.4 8.9 0.1 1 19 741 759 741 762 0.93
4 8 2.1e-06 0.00018 21.9 2.0 1 23 1458 1480 1458 1480 0.99
5 8 8.8e-06 0.00076 19.9 5.3 1 23 1486 1510 1486 1510 0.92
6 8 0.0001 0.009 16.5 2.6 2 23 1967 1988 1967 1988 0.97
7 8 0.0006 0.052 14.1 1.2 1 23 1994 2018 1994 2018 0.91
8 8 0.0019 0.17 12.5 2.7 1 23 2039 2063 2039 2063 0.92

Sequence Information

Coding Sequence
atGGAAAATGCAAGCACCACAACGGCCAAGCATTACAAGACCGCAGGCAAACAGTACAAGACCAATAAACCAGTGGCCATCGCCACAAACAACCATAACATCAACAATACGCCCGCCACCGATGGACCCGCCCTCGGGGATTGGTCCAGCAATATTCAACGGTATCTTCACAAGAAGTTTAAGCGCTTGGCCAGCACCACAGATGTCGAGAGCGGGAATGCGACGGCGAACGGTGGCCACTTGACCTCCGCTGATGCCGGTATGCGCACCACATCGCTGTCCTCAAATAGCTCACTGTCACCTCCACCGCCTGCAGCGATGGTCACCAATGGTCACCATTTGACCCAACAGCTACCGGcgcagcctcagcctcagcagCAAAATAGACCGCCGCCGACCGCTGCCatcgccgccaccaccaccaccaccacacatGAATTCAGTGCCAATTTTGTAAATAGCAATCATGTCAATGCCATTGGTCATGAGGAGAGCAATAGCCACAAAGCAGCGTTGAATGCGAGAACGCGAACGCCGCTGACtaacagcagcatcagcagcagcagtaactATGCAGCGAATGCCACACTCTCGCCGGCAACCTTTGCCCAGCATCAGCAACTGACGCAGCCAACAGCGGGAGGAGGAGCCGGGATTGCAGGCGGAGGTGGAATAccaggcggaggcggaggtaGTGGAGCAGCATTAGCAGCAGCCGGCGAGAAGGCCGGACGCTATGTGTGTCCATACTGCAATCTGATTTGTGCCAAGCCCTCGGTGCTGGAGAAGCATATACGGGCCCACACCAACGAACGGCCATATCCTTGTGACACCTGCGGCATTGCCTTTAAGACCAAGAGCAATCTGTACAAGCATTGTCGCTCCCGGTCGCATGCGGCAAGAGCCAGGGGTTTGGAAGTGCCAGCGGATGCCGACGATGGACTGTCCGATCAGGATGCTGAGCTAAGCAACAGTAGTTCGGAATTGccAAGTCGCGCTGGTTCGCCATACGATGAGCCCATGAGTTCGCCCACACCCTCACCTTCCACGCTGTCGGCGGCCAAGAGCGCCTACAtccagcagccgccgccactTCCGCAGCATATGCAACAATTGCCGCTGGGCTCGCCGGCTGCTGGCACCTTGCCGCCCACAACGGCGGACAATCTTCATTCGGCCACTGCCCAGCATCGTCAGTCCATTGACTACAAGCCATATAAGCCCAAGTTCCACAATGCCTCCTTGTATGCCCCAGGCAGTAgcaaagagcagcagcagcagcagcagcaacagttgcagttgcaacagcaacaacagcagcagcagcaacatcagcaattGGCCCAGCAGAAGCTATCCATTCAGCTGCCATTggtacagcagcagcagccatcgCTAGCTCATCCCACGCTCTCGCCTAGCACACAGATGAAAATGAAGAACCACATTAACTCGCATCAGCTTcaaatgcagctgcagcaccaATTGCATGCCCAGCAAAGCCTTTTGGCCTCCATGCCGCCAGTGCCACCGGCCGGAGTCTATTACCTGGGACAGTCACCTTATTATAACCAAGATCCTACGGCGGCGGCCATTCATCACAATGCACTGGTCTTCCAGCAATTGCAACTTCAACAGATCCACCTggcgcatcagcagcagcaacaacaacaacagcagcagcagcaacactctCCTTTGGTAAAGGCACCAACGCCAATACAGCAGCCACCAAGTCTTCCGCCTCAACAGctgGTGCGAGCCAACAGTCAGGTTTCCAATGTCACACCAGctcctgccacgcccacacctgctgctgccgccaatCTCAGCACTTTTGCCAGCTCCAGTGGCAGCATGCAAGTGAATGTGGCCAAGGTGCAGGAGCATATATCCAAGTTGATCTCACAAAACGAGGCTATAACCATGCAATATCGCCAGGATCCTGCAACGCCAGTGGCTAAAATGGACCAACCGGCCACGGGTGGACATGTGATGCCTTTGAACTTGTCAGCGAAGCCAAAGCCCGCCGTCATTACAGTGCCCGTAAGCTCATTGTCGAGCAGTTCTGTgccagccacgcccaccacTTCAGGAACTTCGTCGAGTACCTCCAAAGCGGCACCGCCAGCTGGACAAATTAATAACTCAATCATTAAGAATCTGCTGTTAAATGCACGAGGCTTGGCGGTCCCCATTGGCGAGGGAGACGATGCCGTTTACTCGTGCCCGATCTGTGCCAGTGAATTCCGCAGTGCGGACGATCTGAAGCTGCACAACAGTACCTACTGCCAGGATGCGAGCTCCAGTGCACCAATGAGTCCAGCCTCGTCGCCCTTCCGCTCCAACTCGATCTCGTTAAGTCTGCCGGAGCTGAAGAGTCACATGGCCAACTCGAAGAATCCGCTATCACTGGCCAAATTGGCCTGGTCGCAGCTTAAGACCAAGCGGAGCAGTCTGGTGGCGAGTCGCCTGAATGCAGCGCAGACGCCAGCGAGAACGTCAACGGTGACAGCCACCACAGCAAGTGCTTCTGCCGCCCCAGCACCAATTCCCGCGCCACAACTGCCCCTTGAGAGTCTGCGCTTTGTGGATGCACCACTGCCATCGCCAGGTCCCCTGCTTGGCAAGACGCCTTTGGTGGATTATGCCCAGCAGAATGCCCCACGCAAGGCTCAGGATTCGGTGGTCATAACAAAAATGCACGAAGATCGTCAGTTTGCAAGCTTGGATATAGAGGCTCCGCATGCCAAGCGTGTGAAGACTAGCGATCTGGCTGCTTCgacatcctcctcctcctcgcaaGGCTTCTCCTTTCCCTTTACCAaccacaataacaacaacaacagcctgCCAGAACCGCAGCCCATCAAAGAAGAGCGCCTACGCAGGTTTACATCGTCAGGTGGCACAATGATTCCCATTTCGGAATGCCCCGACTTGGAGAACAGTCCCAAGATGATACGTACACCATTGTTATCCGGTGGAAGCTTCCAGGAGGTTTCGGCCAAGGTAAACGATGCAGGATCAAGCAAGGAGCGTAAACGCATGGCCTTGATCAGTGGCAGTGGATTGCTTGGCGTTAGCTCCGGTCCACAGCATTTTCAGTTTCCGCCCATCAATTCGATAACTGCCTTCAATCCGCTTACATTGCCGCCGATGGAGCGCGCTGGAGGCGATAAAACCACTCCCGTAACGCCCATTCCCTATGTGCCAGGAATTCCAGGGCCAGGAAGTCTCACGCCGCAAATGCcattgctgccgccgccgccacaacAACTGCAGTTGCCGGTTCCTTCGGGTCGTGGACGTAGCCCGAATCGCAAGCAACCCAGTCCCTTGCTAATGGGAACAGCTGGCGTTGCTGGTGAACTGAAGGCTCTGTCGCCCTTTGGCGGTGTTCAGAATTTGCCCAGCGAATTCAGCCGCCAGCCACCGACTCCTGCCCAAAGGCAGGCGCTGCAGTGGAACAGCAAGGAGACGACTCCGAAAAAGGCACCATTTAACTTTCTGCGAATGGCGGATAACGTCAACAAGGCAACCACGGAACCGGAAGTGCGACACTTTAATCTGGACAATGTGATTGCTGGGAAACAGCAAGAGTCATCGCCGCTGACACCACTCCACGTGGAGACGCCCAATGGGGGTGCCACagaggaggcggcggctggTCAAAGTACCTCAGCGAAATCAAAGTTCCTGCGACCCACCAGTTTGCCACTGAAACCGGGCACATTTACGCCAAAGCGTCATCATGGGATTACGCCCACGGCCAACACTTTGCCACTAATCTCGCCAGAGACCCCGCGTCCATCCAAGTCCTGTGTGCAACTATACCTTAATGGCCATGCCTACACCTACCTGGGTCTCAAGTGCAGCACCAAGATGTTCTATTGCACGGTCAACTGTCCGCAGCCCTCGTATGTGGCGGGCATGCACAAGCTGTCGATGTACAGCGTGTGGCAGGTGTGCGAGGAGAACCAACCGCATCCCCTGGGTTTCAAGCTGAAGAAGGTGATGTCGCTATACGACTCCCGGCAAAGGTTGCTGGGTAATGGCAGTTCCACCGCCATGGCTGGTTTGGGTAAACTGAGCTACAATGTGGTCTCCTCCCAGCAAACAGTGTGCTCCACATCCACCTTGGttagtgccagtgccagtgccttTTATCAGAATCAGCTTAAGACGTCGTCATCAGCTGTCACAGTGTCGGTTTTGAGCGAGGCCAATGTGGCGGCCAAGGCGaacgaagaggaggaggcggcggcgcaGGCCAAGAAGCTGGAGACCAGTCCCTCGGGACAACCTCTGGTTGGTGGCTACGAGTCGCACGAGGATTACACCTATATCCGGGGCCGGGGACGTGGCCGATATGTGTGCTCAGAGTGCGGAATCCGCTGCAAGAAGCCCTCGATGCTGAAGAAGCACATACGCACCCACACGGACGTAAGGCCGTTTACCTGCAGTCACTGCAACTTTAGCTTCAAGACCAAGGGAAACCTGACCAAGCACATGCAGTCCAAGACCCACTTCAAGAAGTGCATCGAACTGGGCATTAACCCAGGACCCATGCCAGCCGATGGTGAGTTCCTGGATGTGGACATGGACTTTGATCAGCAGTCATCGACCTCGGCAGGAGGACGCACATCCTCAATGGCGGGAGAGTCCGATTCGGATGATTATAGCGACAATGAATCGGAGAGTAGTGACACAGACGAGTCCAAGTCCCGGTTGAAGGAGCACGAGGCAGCCAGGTGCCTGCTGTCGCTATCGATGACGCCGCCCATTCCACAGAGTGTGTCGCCCTATCCCCAAATGCTGCAGGATACACCTCTGCCCGCCGCCAGTCCCGCGAACAGCATCGGATCCTCAGGATCATTGCCCAAGCGTTTGGTGTGCTCATTTACCTCGCCAAAGCCACCGTTTGACTATCAGAAGCAGGAACAGTATTACTCTAATCCGGAGGAGTCCAAGCCAAAGCGCAGCGTGGCCAGCGAGGAGAGCGCTCCCATGGATCTCACCAAGCCGCGTGGATCCATGTCGGCCGCCGTTTCGCCATCGCCAATGccagtgccgccgccgccgcacgTTCAGGATCTGCCCAAGTCGCAGGCCCAGCAAATGCACGATGTGATCTTCGGGAGCTCTGGCAATGAGAGCGGCTTCATGAAGACCTTGATCTCTGTCTCGGATAAGGTGCGCATCTCCGCCGAAATGGAGGAGCAGGCCAAGCACGAGGCCGAGGGGGAGGATGTTCTGCTGCAGACCTATATCAAGGAGCAGGCACTGCATCATGCCAAGCGGAAGCAGAGTCAGTTCAGTGGCAGCTACCTAATCAACACTTTGTTCTCCACGGCCTCCACGGTGatgagtagcagcagcaacctctTGACCACCAGTAGCCGACCCATTATGACCATTAATGAGGTGCCAAGCATCGAAGTGCATGAGGTAAAGACGCCAGAGGCTGTGGATCTGCCACCTATACCTCCTGTGGTTGCTCCACCAACTCCAACACCCACGCGCACACCCACTCCCGTTCCTGTGAAGACCAACCAGGAGGAAAGTGAAGAATCGGATCAGGAGAAGCCCATGGCAGAGCCATATAATGCCAATCTGCCGGCTGCAGTGCAGCAGAAGGATGCCAATGATTTCAGTGGAGTCCTGGGGCATTCACAGTCTGGAGGAGCAGCCACTGTGACCACATCTACACCTGCTTCCGTGGTCGTATCCTCGACGAACACGACTCAGCCCACGCAGCAGCGTACTGTGATTGTGGGCGAGGATGGTTTCAAGAACTCCACGCCCAGCAGCAAGAGCAGTGATCTCCAGCAACAACATGTATCCTACGGCCGAGCAGTGCCAGTTCCTGCACCAATTGCCAGCGATGTTCGGCCCACCTGCTCCATCTGCGCCAAGACCTTCCAGCGCCAGCATCAGTTGACCCTGCACATGAACATCCACTACATGGAGCGCAAGTTCAAGTGCGAGCCATGCAGCATCTCCTTCCGCACGCAGGGACATCTGCAGAAGCACGAACGTTCCGAGGCGCACAAAAACAAGGTGATGATGACCTCGACATTCGGTGTTCCCACCACCTCCAATCCACGACCCTTTGAGTGCACCGACTGCAAGATCGCTTTCCGCATCCACGGCCACTTGGCCAAGCATTTGCGCTCGAAGACGCATGTCCAGAAGCTGGAGTGTCTACAGAAGTTGCCCTTTGGCACCTATGCCGAGATCGAACGCGCTGGCATCAGCCTCACCGAGATCGATACCAGTGACTGTGAGAACTCCTTGATATCTCTGAAGTTACTGGCCCAAAAGCTATTGGAGAAGGATCCCAATAAACTAAACGGATATACCACACCGTCCGGCATGATGCAGCTGGCCCAGGACCCGACGAATCCTGCCTCGCAGGATAGTGCCTCCGAAGACGGTTTTAGTGCTGCTGTGGCCATAGCCTCGGCCATTGCTTCCCTGGACAATGACAGTGCCGGCAATACACCGAAGCGGGCCAGCTCGATGTCCGAAGACGAAACTGTGGCCAACGGCCTGAATCACAACCTGAAGCGCCGTTTGCCCGGCAGTTTCAGTAGCACGGGTGAGGAGAGCGATAATCCAACCGAGGGCAATGGCGGCGAGAAGCGTGCTCGTTCCAGCCAGGATCTACCGGTTGCTGTTCCCGTTGCTGCttcagcagcggcggcggcggctagCAACTGA
Protein Sequence
MENASTTTAKHYKTAGKQYKTNKPVAIATNNHNINNTPATDGPALGDWSSNIQRYLHKKFKRLASTTDVESGNATANGGHLTSADAGMRTTSLSSNSSLSPPPPAAMVTNGHHLTQQLPAQPQPQQQNRPPPTAAIAATTTTTTHEFSANFVNSNHVNAIGHEESNSHKAALNARTRTPLTNSSISSSSNYAANATLSPATFAQHQQLTQPTAGGGAGIAGGGGIPGGGGGSGAALAAAGEKAGRYVCPYCNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADADDGLSDQDAELSNSSSELPSRAGSPYDEPMSSPTPSPSTLSAAKSAYIQQPPPLPQHMQQLPLGSPAAGTLPPTTADNLHSATAQHRQSIDYKPYKPKFHNASLYAPGSSKEQQQQQQQQLQLQQQQQQQQQHQQLAQQKLSIQLPLVQQQQPSLAHPTLSPSTQMKMKNHINSHQLQMQLQHQLHAQQSLLASMPPVPPAGVYYLGQSPYYNQDPTAAAIHHNALVFQQLQLQQIHLAHQQQQQQQQQQQQHSPLVKAPTPIQQPPSLPPQQLVRANSQVSNVTPAPATPTPAAAANLSTFASSSGSMQVNVAKVQEHISKLISQNEAITMQYRQDPATPVAKMDQPATGGHVMPLNLSAKPKPAVITVPVSSLSSSSVPATPTTSGTSSSTSKAAPPAGQINNSIIKNLLLNARGLAVPIGEGDDAVYSCPICASEFRSADDLKLHNSTYCQDASSSAPMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVASRLNAAQTPARTSTVTATTASASAAPAPIPAPQLPLESLRFVDAPLPSPGPLLGKTPLVDYAQQNAPRKAQDSVVITKMHEDRQFASLDIEAPHAKRVKTSDLAASTSSSSSQGFSFPFTNHNNNNNSLPEPQPIKEERLRRFTSSGGTMIPISECPDLENSPKMIRTPLLSGGSFQEVSAKVNDAGSSKERKRMALISGSGLLGVSSGPQHFQFPPINSITAFNPLTLPPMERAGGDKTTPVTPIPYVPGIPGPGSLTPQMPLLPPPPQQLQLPVPSGRGRSPNRKQPSPLLMGTAGVAGELKALSPFGGVQNLPSEFSRQPPTPAQRQALQWNSKETTPKKAPFNFLRMADNVNKATTEPEVRHFNLDNVIAGKQQESSPLTPLHVETPNGGATEEAAAGQSTSAKSKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKKVMSLYDSRQRLLGNGSSTAMAGLGKLSYNVVSSQQTVCSTSTLVSASASAFYQNQLKTSSSAVTVSVLSEANVAAKANEEEEAAAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPADGEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRLKEHEAARCLLSLSMTPPIPQSVSPYPQMLQDTPLPAASPANSIGSSGSLPKRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVASEESAPMDLTKPRGSMSAAVSPSPMPVPPPPHVQDLPKSQAQQMHDVIFGSSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGEDVLLQTYIKEQALHHAKRKQSQFSGSYLINTLFSTASTVMSSSSNLLTTSSRPIMTINEVPSIEVHEVKTPEAVDLPPIPPVVAPPTPTPTRTPTPVPVKTNQEESEESDQEKPMAEPYNANLPAAVQQKDANDFSGVLGHSQSGGAATVTTSTPASVVVSSTNTTQPTQQRTVIVGEDGFKNSTPSSKSSDLQQQHVSYGRAVPVPAPIASDVRPTCSICAKTFQRQHQLTLHMNIHYMERKFKCEPCSISFRTQGHLQKHERSEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTHVQKLECLQKLPFGTYAEIERAGISLTEIDTSDCENSLISLKLLAQKLLEKDPNKLNGYTTPSGMMQLAQDPTNPASQDSASEDGFSAAVAIASAIASLDNDSAGNTPKRASSMSEDETVANGLNHNLKRRLPGSFSSTGEESDNPTEGNGGEKRARSSQDLPVAVPVAASAAAAAASN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00594759;
80% Identity
-