Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.4e-06 0.00011 22.7 0.2 3 23 105 125 104 125 0.97

2 6 3.7e-05 0.0028 18.2 0.8 1 23 131 153 131 153 0.95

3 6 1.8e-06 0.00014 22.4 0.2 1 23 159 181 159 181 0.98

4 6 2.3e-06 0.00017 22.0 1.7 1 23 242 264 242 264 0.98

5 6 7.5e-05 0.0057 17.3 1.7 3 23 272 294 270 294 0.88

6 6 0.00056 0.042 14.5 4.8 1 23 300 322 300 322 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.4e-06	0.00011	22.7	0.2	3	23	105	125	104	125	0.97
2	6	3.7e-05	0.0028	18.2	0.8	1	23	131	153	131	153	0.95
3	6	1.8e-06	0.00014	22.4	0.2	1	23	159	181	159	181	0.98
4	6	2.3e-06	0.00017	22.0	1.7	1	23	242	264	242	264	0.98
5	6	7.5e-05	0.0057	17.3	1.7	3	23	272	294	270	294	0.88
6	6	0.00056	0.042	14.5	4.8	1	23	300	322	300	322	0.98

Coding Sequence: ATGCGACAGCCGGGACAGCAGTTGGACCGGGAGCTGGAGCCAGAGGACAGCTACGACTCCTGCCTGACCGAAGATGTGCAGCTGTTTGGGCAGCTGGACGATCTGGATGCCAGCAGCGAGCTACTGCTTTTGCCCTCAACAGCTGAGCTGGACCTTCTGCAGCTGGTTAGTGAAGCAAGCGATGCTACATTGCGtccaacactcacacactccaGCTCTttgcagacgcagacgcagacacagccgcagccgcagccgattaagccgaagtcgaaacgtgccacgcccaccaaacGACAGCCGAGCAACATTTGTGATCTGTGCGGGCGCAGCTTCAGCGATGCCTACGGCCTGCGCATACACCGCATGACGCACACGGACGAGCGGCCGCACGTGTGTGAGGTGTGCGGCAAGGGATTCCGGCAGCTGAACAAGCTGCGCATCCACTCCGTGACACACACGGACAAGCGGCCATACGAGTGCGATATATGCGGCAAGGGATTTCGCTTTGCCAACTATTTGGCAGTGCATCGGCGCCTGCATACAGGCGAGAAGCCCTACAGCTGCATTGAGTCGAGCTGCAGCATGTCCTTTCATTCCATACATGCGCGACGCATGCACATGAAGCTGCAGCAtgccagcagcggcagcggcagcggcagcagtaaAGAGACGGAGGATCAGAAAGAGGAAGATCAAGTTGATTCAACAGCAGCGCTAAGCTTCACCTGTCCCATTTGCGGACGCGTCCTAACGGACCAATGCTATTTGAACACGCATCTGAAGCGTCATTATAACCAGCGCGACTTCGCCTGCCTGCATCCGGGCTGTGGCAAACGCTTCTTTAGCTCCTCGGAGCTCAACCATCATCAGATTGCGCACACGCGACTTCGTCCATTTCGATGTTCGCTGTGCGGCTCGTGCTTCCTGCGCAAATCGAATTACAAGCAACATTTGAAGATTCACTGcgattaa
Protein Sequence: MRQPGQQLDRELEPEDSYDSCLTEDVQLFGQLDDLDASSELLLLPSTAELDLLQLVSEASDATLRPTLTHSSSLQTQTQTQPQPQPIKPKSKRATPTKRQPSNICDLCGRSFSDAYGLRIHRMTHTDERPHVCEVCGKGFRQLNKLRIHSVTHTDKRPYECDICGKGFRFANYLAVHRRLHTGEKPYSCIESSCSMSFHSIHARRMHMKLQHASSGSGSGSSKETEDQKEEDQVDSTAALSFTCPICGRVLTDQCYLNTHLKRHYNQRDFACLHPGCGKRFFSSSELNHHQIAHTRLRPFRCSLCGSCFLRKSNYKQHLKIHCD

Sequence clustering based on sequence similarity using MMseqs2