Dlat015377.1
Basic Information
- Insect
- Drosophila lacteicornis
- Gene Symbol
- run
- Assembly
- GCA_008044355.1
- Location
- VNKF01005370.1:98674-123919[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 5.8e-73 2.2e-69 231.1 0.1 4 129 26 151 23 151 0.98
Sequence Information
- Coding Sequence
- ATGTCTTCAATATCTCCCGTGGACACGAGTCCCTACTTGACGCCGGAGAATCTCATCGAGCGCACCGTCGACGTCCTGCTTGCCGAGCATCCCGGCGAGCTGGTCAAGACGGGATCACCCCATGTGGTCTGCACCACATTGCCCACGCACTGGCGCTCCAACAAGACCCTGCCGATCGCCTTCAAGGTCCTGGCCTTGGGCGAGGTCATGGACGGCACCATAGTGACCATTCGGGCTGGGAATGATGAGAACTTCTGCGGGGAATTAAGGAACTGCACGGCCGTAATGAAGAACCAGGTGGCCAAGTTCAATGATCTGCGATTTGTGGGAAGAAGTGGCAGGGGCAAGAGCTTCACCCTGACGATTGTCATCTCAACGAATCCCATCCAGATAGCGACATACACGAAGGCCATCAAGGTGACCGTGGATGGACCGAGGGAGCCCCGGTCAAAGGTCCGCCACCAGGGCTTCCATCCGTTCGCATTTGGGCCACAGCGCTTCGGACCGGATCCACTTATGGCCGGATTGCCCTTCAAGTTGCCAGGTAAGCGGAGCAGGTGA
- Protein Sequence
- MSSISPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGKRSR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00571683; iTF_00565157; iTF_00613285; iTF_00487785; iTF_00918825; iTF_00488491; iTF_00587916; iTF_00590028; iTF_00515374; iTF_01350449; iTF_00579060; iTF_00600084; iTF_01548631; iTF_00593627; iTF_00491292;
- 90% Identity
- iTF_00515374;
- 80% Identity
- iTF_00571683;