Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00037 0.027 15.1 1.2 1 23 129 151 129 151 0.98

2 5 0.23 17 6.2 0.0 3 23 159 179 157 179 0.96

3 5 0.0059 0.43 11.3 2.5 1 23 185 207 185 207 0.97

4 5 7.6e-06 0.00057 20.4 0.0 1 23 213 235 213 235 0.98

5 5 5.6e-05 0.0041 17.6 5.6 1 23 241 265 241 265 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00037	0.027	15.1	1.2	1	23	129	151	129	151	0.98
2	5	0.23	17	6.2	0.0	3	23	159	179	157	179	0.96
3	5	0.0059	0.43	11.3	2.5	1	23	185	207	185	207	0.97
4	5	7.6e-06	0.00057	20.4	0.0	1	23	213	235	213	235	0.98
5	5	5.6e-05	0.0041	17.6	5.6	1	23	241	265	241	265	0.93

Coding Sequence: ATGTTCGTAAAAATGTGCCGGATCTGTGGAAGAAGCATTGTTTGCCAAAAGAGTAAAAATCTATTCGAATCAAGCAATAGGAAGCTTGTGCGGCATATTCAAATAGACAGCGACTCGGACGAGGAACCGCAGCAAACAGTACAAGTAATGATTAAAGAAAGCAAAATACTTACCAATTTGGACAATGCTGACGGAGATCAGGAACATGATCATCTGGATCTAGACTATGTAATAAAGGCTAATACAGACGTCGATACCGACGATAGTGTGgatattaaaatcgaaaagaaagaaagtgaCGATAACTATGCGTCCTCCAAGCCAATCATACATATCACAGAGGCATgcaaaaaactattaaatgcCAAACATGAAGTGGCCATCTACATCTGCGAACTGTGCGGGACACATGTAAACAGCAAGGCCTCTTTTGATCGTCATGTACGGAAACATACGGGGGAGCGTCCATTTGGCTGCGAAGATTGCGCGGCGCGTTTTTTATCCGCTGCTGAACTGAGATCACATGGTCTTACCCACACTGGAGAGCGACCGTTCCCATGTCACTACTGTAATCGCCGATACGTTAGTTATATGGGAAGACTAAAGCACGAAAGAATCCATACCAATGAGCGGCCTTTCGTTTGTGCAGAATGTGGCAAGGCTTTCGCCAATGCCTATATACTAAAGAATCATATGCTGGTGCACACAGGCGAGCGTTTGTTTAGATGCGAACTCTGTCAACGATCATTTCAGCGAAAGACTCATCTGAGAACGCATTATCGTTCCAATACCCACAAGCTAAACGTAGAGAAGAATCAAGACAGTAGTATAGTCGATATAGCCCAATAG
Protein Sequence: MFVKMCRICGRSIVCQKSKNLFESSNRKLVRHIQIDSDSDEEPQQTVQVMIKESKILTNLDNADGDQEHDHLDLDYVIKANTDVDTDDSVDIKIEKKESDDNYASSKPIIHITEACKKLLNAKHEVAIYICELCGTHVNSKASFDRHVRKHTGERPFGCEDCAARFLSAAELRSHGLTHTGERPFPCHYCNRRYVSYMGRLKHERIHTNERPFVCAECGKAFANAYILKNHMLVHTGERLFRCELCQRSFQRKTHLRTHYRSNTHKLNVEKNQDSSIVDIAQ

Sequence clustering based on sequence similarity using MMseqs2