Basic Information

Insect: Drosophila kuntzei
Gene Symbol: topi
Assembly: GCA_035042165.1
Location: JAWNLU010000818.1:4200175-4203118[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 3.3e-06 0.00025 21.5 0.8 2 23 230 251 230 251 0.97

2 9 0.031 2.3 9.0 0.2 2 23 277 298 276 298 0.92

3 9 0.0069 0.51 11.1 0.1 2 23 361 382 360 382 0.94

4 9 0.019 1.4 9.7 1.2 1 21 429 449 429 453 0.90

5 9 5e-07 3.7e-05 24.1 1.9 1 23 515 537 515 537 0.95

6 9 0.00051 0.038 14.6 1.1 1 23 543 568 543 568 0.96

7 9 0.43 32 5.4 1.7 1 23 574 596 574 596 0.88

8 9 3.8e-08 2.8e-06 27.6 0.4 1 23 602 624 602 624 0.99

9 9 0.0007 0.052 14.2 1.2 1 23 630 653 630 653 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	3.3e-06	0.00025	21.5	0.8	2	23	230	251	230	251	0.97
2	9	0.031	2.3	9.0	0.2	2	23	277	298	276	298	0.92
3	9	0.0069	0.51	11.1	0.1	2	23	361	382	360	382	0.94
4	9	0.019	1.4	9.7	1.2	1	21	429	449	429	453	0.90
5	9	5e-07	3.7e-05	24.1	1.9	1	23	515	537	515	537	0.95
6	9	0.00051	0.038	14.6	1.1	1	23	543	568	543	568	0.96
7	9	0.43	32	5.4	1.7	1	23	574	596	574	596	0.88
8	9	3.8e-08	2.8e-06	27.6	0.4	1	23	602	624	602	624	0.99
9	9	0.0007	0.052	14.2	1.2	1	23	630	653	630	653	0.95

Sequence Information

Coding Sequence: ATGGATGAGAACTTGCAAGTGTTTGGGGATGGTGAGTTCGTGATGGCGGAGTTCGAGTGCGAAACCGATTTGGTGGATCGCAGTGGAGAATTGCACGAGGGAGCAACTGTGCTGGTGGCCAATGAATCTGATGGCATTGTTAACTTTGAAGATTTAAGCAAGTTCTTTGATATGTCTAATGTCATTGAGATTCAGGCAGAGGATACCGTTGAGCGTACATTGGCGGATCCGGCACTAAAGCAAATACTGCAGGAAGCCGATGGTAAAGTTGACTTCGATCCAGAAGCAGAGCAAGAAAAATTGCGAGAATTTCTTGCGGTAGCAAACAATAAGATTGCCAGCAAGAAACCTATAGGGGGATCTTCGTACTCGCAACCTGTGGTTGCGCCTTCAAACTCATTTCGGGTGATCAAGTGCTCCAATTGCAGTGGACTTTTCGATTCGCCCTCATTCCAGACTCACAGCTGTGAATTCGATTCGAATCAGAAACCGATTGTGACTCCTCAAAAAATGGCACCGCCCCCGGATAAAGTGGCGTCTGTGCCACCAAAGAAACCACCCAGTGAACGCATCATCGTGGAGAATCAGGTGCGCATACGTCGCTATATGAAGGAAGAGCTCAAGTATGATCTGGAAACGGGTGTCGACAGTTCGAAGATCAAGAAGTCATCCACCAAGGGTCCCAACGAGTGCAATATTTGTGATCGCAAGTTTGTGCATGCCTCGGGATTGGTGCGACACATGGAGAAGCATGCTCTGGACCTGATTCCCACTCAGACCAGTGTGCAGCACACGGCGGTGGCTGCACTAGGTCTTCTGGTCGTTCTTAAATGTCATCTCTGTGGACGCATTTTCTATGATGTCAAACTTGCGCTGGAACATGTCCTTGTACATAATCAGCCGGTGGTCGAGACCAAGAAGTCCACACATGTtcaagaaaatgaaatggaattgaAGAGACAGCTGGACATGCTCATGGTTGAAGGAGAACAGCTATTGGCAGTTGCGGAACAACTGGAGATCATGTCACAAGACTCCGAGAACCCGTATTTTTCCACACTCATCTTGAGCAACGTGCTCCAGTGCGAATTTTGTGACTATGTATTTGCCGATGTCTCCTTTTTGTTGGTACATTCGGCCAGTCATGTGCCGGAGCGTCGGTTTGAGTGCACCGCTTGCGACCTGCGCATGACCACCGCCAAGGAGGCCAGTGTGCACTATCAGACCGACTGTGTCTACATGCGCGAAGGATTAAAGCAGTTGCAGACGTCTCCCAATCGTTACTTTGTCTGCAACGTGTGTGAGCTGAAGTTTGCAAATGTGGAACTGCTCCAGGAACATCGttacagttgctATCATTACTTTCCGCGTCTCAGCGAGTCTGGCAAACGTCTTCTCCTTCCTTGTGAGTTCTGTGCCATCAACTTTGAATATGCCCATGAGATCCAGCCGCACTATGAGGAGAAGCATCTAAATAAGAAGAAACGTGAGAAAGAAATACGTAATATTGGTAATCCCACGACTGTGGGCCGACTTCGTCAATATCTATGCGACATTTGTGGCAAGTCATACACACAGTCAAGCCACTTGTGGCAACATTTGCGTTTCCATCAGGGTGTGAAGCCCTTCGTTTGCCAGGAGGAGAACTGTGGACGAAAATTCACAATACGTCCGGACCTCAATGATCACATTCGAAAGTGTCACACGGGGGAGCGGCCGTATCATTGTCTGGTGTGTGGCAAACGTTTCCTGACCGGCTCCGTCTTCTATCAGCATCGCCTCATCCATCGTGGCGAGCGGCGTTACGAGTGCGATGAGTGTGGCAAGAGATTTTATCGTGCGGATGCCTTAAAAAATCATCAGCGAATTCACACTGGTGAAAAACCATACGATTGTCCGTTCTGCACAAAGACATTCCGTCAACGTGGTGATCGTGATAAGCATGTACGGGCACGCCACTCTCAGTTGGATGCAAATGCCCGCTTGATGATGCAGATGCAGAAATTTGAGTTGGAAACCGCGGCTGCATTGAAGGCCAAGCAAATGCAGGAGACTACTAGTGATAGCGAGTTTATTGCTGAAACGCCATCTGTTTCGTTACCTCATTTGCCACCATCTTCCGTTATTTCGGAGCAGCAATTCGAAATGGTGGAGATAGATCCCAATGATTTCTGCGAAGCACCCGATTTTGTacaaatgccaatgccaattgATAATACAGATTTCGAGGTTATTAACTATGGGGAGCTTGAAGGAATGGGACCAGTCGAGGCGCCACAATTTTCAACGGAAAATGCTAAAGTTGTGGTCGTTGAAAATAATTCTTCGCAgccgttttatttttaa
Protein Sequence: MDENLQVFGDGEFVMAEFECETDLVDRSGELHEGATVLVANESDGIVNFEDLSKFFDMSNVIEIQAEDTVERTLADPALKQILQEADGKVDFDPEAEQEKLREFLAVANNKIASKKPIGGSSYSQPVVAPSNSFRVIKCSNCSGLFDSPSFQTHSCEFDSNQKPIVTPQKMAPPPDKVASVPPKKPPSERIIVENQVRIRRYMKEELKYDLETGVDSSKIKKSSTKGPNECNICDRKFVHASGLVRHMEKHALDLIPTQTSVQHTAVAALGLLVVLKCHLCGRIFYDVKLALEHVLVHNQPVVETKKSTHVQENEMELKRQLDMLMVEGEQLLAVAEQLEIMSQDSENPYFSTLILSNVLQCEFCDYVFADVSFLLVHSASHVPERRFECTACDLRMTTAKEASVHYQTDCVYMREGLKQLQTSPNRYFVCNVCELKFANVELLQEHRYSCYHYFPRLSESGKRLLLPCEFCAINFEYAHEIQPHYEEKHLNKKKREKEIRNIGNPTTVGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSQLDANARLMMQMQKFELETAAALKAKQMQETTSDSEFIAETPSVSLPHLPPSSVISEQQFEMVEIDPNDFCEAPDFVQMPMPIDNTDFEVINYGELEGMGPVEAPQFSTENAKVVVVENNSSQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00534049;
90% Identity: iTF_00602038;
80% Identity: -