Basic Information

Insect: Drosophila kokeensis
Gene Symbol: topi
Assembly: GCA_035042145.1
Location: JAWNLT010000520.1:1129562-1132230[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 4.9e-05 0.0032 17.8 2.4 1 23 225 247 225 247 0.96

2 10 0.26 16 6.1 0.2 2 10 273 281 272 295 0.83

3 10 0.0022 0.14 12.6 0.1 2 23 341 362 340 362 0.96

4 10 4 2.5e+02 2.4 0.1 1 22 368 389 368 389 0.91

5 10 0.018 1.2 9.7 1.2 1 21 409 429 409 433 0.90

6 10 4.8e-07 3.1e-05 24.1 1.9 1 23 497 519 497 519 0.95

7 10 0.00025 0.016 15.6 0.7 1 23 525 550 525 550 0.97

8 10 0.42 27 5.4 1.7 1 23 556 578 556 578 0.88

9 10 3.6e-08 2.3e-06 27.7 0.4 1 23 584 606 584 606 0.99

10 10 0.00049 0.032 14.7 1.8 1 23 612 635 612 635 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	4.9e-05	0.0032	17.8	2.4	1	23	225	247	225	247	0.96
2	10	0.26	16	6.1	0.2	2	10	273	281	272	295	0.83
3	10	0.0022	0.14	12.6	0.1	2	23	341	362	340	362	0.96
4	10	4	2.5e+02	2.4	0.1	1	22	368	389	368	389	0.91
5	10	0.018	1.2	9.7	1.2	1	21	409	429	409	433	0.90
6	10	4.8e-07	3.1e-05	24.1	1.9	1	23	497	519	497	519	0.95
7	10	0.00025	0.016	15.6	0.7	1	23	525	550	525	550	0.97
8	10	0.42	27	5.4	1.7	1	23	556	578	556	578	0.88
9	10	3.6e-08	2.3e-06	27.7	0.4	1	23	584	606	584	606	0.99
10	10	0.00049	0.032	14.7	1.8	1	23	612	635	612	635	0.95

Sequence Information

Coding Sequence: ATGGATTTAGAATCCGAGTTTTACGATGGCGGTGAATTCGTTATAACCGAATTCGAGCTCGCTGATGAATTGATGGTGGACATGGATAATGAATTGCAGCCAGGATCCACTCTCCTGGTGTCCAATGAAAGCAATGATATTCTCGTTGAGGAGGATTTGGATCAGTTCTTTGAGTTGCAGGGCGGCATTCAGATACCCACCGAGGAGGTTGTGGAACATACGTTTGCAGATCCGGCGCTAATGGGAATCCTGGATGAAGCCAACGGACAGATGGATTTTGATCCGGAAGCAGAGCAACTCAAATTACGCGAGTTCTTATCGGGCGCTAACAATAGCATCGAGATGAACGCGTTGCCCGGTATGGTGATCCAAGAGAATACAAATCCTGTCGTCCGTTTCATCCTGTGCTCCAATTGCAAAGGAATCTTCGATACGCCGGCATTCCAAAATCATATCTGTGAATACGATGCGAACCAGAACAAAATCGAAGCGCAGCAATTGCCACCACAGCCGGAGATGAAGGAATCTTCGCCACCCAGGACAATGACCAGCGAGCGCATCATTGTTGAGAACCAGGTGCGCATGCGTCGCTATATGAAGGATGAGCTCAAGTATGATCTGGAGACTGGGTACGACAGTTCCAAGGTGAAGGAGTCGACTGCCAAGGGCACCCACGATTGCAATATCTGTGAGCGCAAGTTTGTCCACTCCTCTGGCTTGGCGCGTCACTTGGAGAAGCATACTCTGGACCTAATCCCTGGACAGGCAACGCTGCAACAGAATCACACATCGAGGCTTGGCGTCCTTATCGTCCTCAAATGCAAACATTGTGGTCGCATTTTCCTCAACGCCAAACTTGCGCTGGAACACGCCTTTGCGTATCACTTGACCAGCGAAGTGGTCAAATCAAGAAATGCgaataaagtgaaattaaagcagcagctcaaattgCTACTGATGGAGAAGAAGCAACCGCAATCGAAGGAAATCTTCAAAAACCAAGTGGTGGCCAATGTCCTACAGTGCGAATTTTGTGACTACATCTTTACCGATCTTGCCCCGCTTTTGCGCCACTCGGCCACCCATTTGCCGGAAAGTCGGTTCGAGTGCACCGCCTGTGATTTGCGCCTGAACACCGCCAAAGAGGCCAGTGTTCACTACCAGACCGAATGCATCTATATGCGCGAGGAACTCAAGCAACTGCCATCTGCGCTGAATCgtgtatttgtttgcaatGTGTGCAAGCTGAACTTTGCCAATGTGGAACTGCTTCAGGACCATCGCTACAGTTGCCTTCACTTCTTTCCGCGGCTCTGCGCGACCGGCACACGGCTGATGCTGCCCTGTGAGTTCTGTGCCACCAGTTTTCAGTGTGCCAACGGGATTCAGGCCCACTACGAGGAGAAGCATCTCAACCGAAAAAAACGGGAGaaagagcagcagcgcaaCATCAGCAGTGCATCATCGTCCAAGGTTCGACTGCGTCAATATCTATGCGACATCTGTGGCAAATCCTACACACAGTCCAGCCATTTGTGGCAACATCTCCGCTTTCATCAGGGTGTCAAGCCATTTGTTTGCCCAGAAGCAAACTGCGATCGTAAATTCACGATACGTCCGGATCTCAATGATCATATAAGAAAGTGTCATACTGGAGAACGGCCGTATCATTGTCTGGTTTGTGGCAAGCGTTTTCTCACCGGCTCGGTCTTTTACCAGCATCGACTCATCCATCGTGGCGAGCGGCGATACGAGTGTGAGGAGTGCGGCAAGCGTTTCTATCGCGCAGACGCATTGAAAAACCATCAGCGCATCCATACGGGCGAGAAGCCCTACGACTGTACATACTGCACGAAAACGTTTCGACAGCGTGGCGATCGCGATAAGCATGTGCGAGCGCGTCACTCCCACTTGGATGAGAATGGTCGTCTGATGATGCGAATGCAGAAGTTAGAACTGGAGAAGGCGGCTGCGTTGAAAGCCAAGCAAATGCAGGAGTTGGGTAATGAATATATGGTGGAGTCGGAGGATGCGTTGTCTGTTCATTCGGAAGCATCTCCGTCAGCACAAGAGCAACATTTCGATTATAATGAGTATCCCGACGAAACTGAAGTTGTATcaatgccaattaaaaatgcgcCGAATTTAATGTCGTGTTTGGATTTTGAGGGAGTAGAATCAATCGAGGCGCCACCttttaatttggaaaataatgaaaatgtcaagGTTGTGGTGGTTGAAAATAATTCTTTGCAGCcattttatttctaa
Protein Sequence: MDLESEFYDGGEFVITEFELADELMVDMDNELQPGSTLLVSNESNDILVEEDLDQFFELQGGIQIPTEEVVEHTFADPALMGILDEANGQMDFDPEAEQLKLREFLSGANNSIEMNALPGMVIQENTNPVVRFILCSNCKGIFDTPAFQNHICEYDANQNKIEAQQLPPQPEMKESSPPRTMTSERIIVENQVRMRRYMKDELKYDLETGYDSSKVKESTAKGTHDCNICERKFVHSSGLARHLEKHTLDLIPGQATLQQNHTSRLGVLIVLKCKHCGRIFLNAKLALEHAFAYHLTSEVVKSRNANKVKLKQQLKLLLMEKKQPQSKEIFKNQVVANVLQCEFCDYIFTDLAPLLRHSATHLPESRFECTACDLRLNTAKEASVHYQTECIYMREELKQLPSALNRVFVCNVCKLNFANVELLQDHRYSCLHFFPRLCATGTRLMLPCEFCATSFQCANGIQAHYEEKHLNRKKREKEQQRNISSASSSKVRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEANCDRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYDCTYCTKTFRQRGDRDKHVRARHSHLDENGRLMMRMQKLELEKAAALKAKQMQELGNEYMVESEDALSVHSEASPSAQEQHFDYNEYPDETEVVSMPIKNAPNLMSCLDFEGVESIEAPPFNLENNENVKVVVVENNSLQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00557382;
90% Identity: iTF_00574277;
80% Identity: -