Dkok008186.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila kokeensis
Gene Symbol
Hsf
Assembly
GCA_035042145.1
Location
JAWNLT010000264.1:11026098-11029895[-]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.6e-36 1.5e-32 112.0 0.1 1 100 53 152 53 152 0.97

Sequence Information

Coding Sequence
ATGTCCAAAACGCGGGCAAGCTTTAAGGCCGTGCAATTAAAGCACGAATCCACGGAAGAAGAGGAGGACGAAGAGGAACCACAGCAGCTGAAGCGACCACGTCGGAATATTATGCATACAGTCGGGGAAAATGTCAGCGGCAGCGGAGTGCCTGCATTTTTGGCCAAACTGTGGCGCCTCGTTGACGATCCcgatacaaataatttaatttgttggagCAAGgaTGGACTCAgttttattatacaaaatcAGGCGCAATTTGCGCGCGAACTTTTGCCACTCAACTATAAGCACAACAACATGGCCAGCTTCATCCGACAATTGAATATGTATGGCTTTCATAAGATCACCTCAATTGAGAATGGCGGGCTACGATTTGATCGCGATGAGATTGAGTTTTCGCATCCGTGCTTCAAGCGCAATTATCCGTACCTGCTGGATCACATTAAGCGCAAGATATCGAATACGAAGACTGTGGATGATAAGAGCGTGCTAAAGCAGGAGACCGTCTCCAAGGTTCTCAGCGATGTGAAAGCTATGCGTGGTCGCCAAGATAATTTGGACTCACGCTTCTCGGTGATGAAGCAGGAGAACGAGGCATTGTGGCGCGAGATAGCCTCGCTCCGTCAGAAGcatgccaagcagcagcagatcgtCAACAAGCTGATTCAGTTCCTCATATCGATAGTGCAGCCATCTCGCAATATGTCCGGCGTGAAGCGTCACATGCAGCTAATGATCAACGATAAGCCGGAGAATGCTCGCAAGCGCAACGCCAGTGAATCGGGAAGCGAATGCGGTCCAGTTATACACGAGTTGAGCGAGGAGCTGCTCGACGAGGTGATGAACCCAAACAGTCCATACGCCAAGCATTATGATGCCGACAGCGAATCACCGGCGCCCATGGAGCGACCACGCTCCAACATGAGCATCACCAGTTCGCAAAACTACGATTATTCGAATCAGAGCGCTGAGGATTTTATAAATGTTCAACTTTTGAATAGCGGCGGCGAGGCAAGAATCAATGCGCAATGCTCACCGGGCGGCCAACAGGAGCTCTATACGGTCACCGAGGCGCCCGATTCACATGGCCAGACCAGCCCTCTTTATAATGGCGATGAACATGCCAATGTGCTGACCACGCCTATGGTGCGGGAGGAGGAGGCACGCAATCGTCAGTTGCTCAAGGAGCGAAACAAACTGCGCCGTCAGACAGACATCACTGTCGACCTTGACATGTCCCCGAAGACCACACGCACGCGATCCCAGGCCAAAGAGCAGCCGCAAATCATGCCACAGCCGGTGCTGGTCAAGGCAGAGCCGGCTGCAGTTAACATGCCCAGCTTGCTCGATCAGCCGGAGTCCAGCAATGCTGATATGTATAATGTCAACTTTATTAGTAACGATATGCCGACAAATATCTTTGAGGATGATTCATTGCTGTCAAACACTGGCCTGGATGAGCATGTTGCCGTCCAGGaagatcagcagcagcagcagcagcaacagttcgGACTCTCCACAGTTAATAGCGGCAAGTTTGCCAATGTTCCAATCAACTTTGATTTGACCAATAGCGGCAATGAGAATGCATTGGTATCTGATGCCAATTTGGCCTCcacttcagctgctgcagctgctgctgtcaaagATTTGGGCAAcgaacaacgacaacaacaacaaaaaccgcaATCAGataaacaacaagagcagTCGCCAGCAATGACTGTGGCCAAATACACTGGCGATAATGGACACGTTGATGAGGTCTCTGGTCATCTGGACAATATGCAAGACGAACTTGAATCACTTAAGGATCTGCTGCGAGCCGAGGGCGTTTCCATTGATCAGAACATGTTATTGGGCGCGGCGCCAAAAGGCGTTGCTACCAGGATGGCCCCGTTGCAGCTAAGCGACGAGGAGCTGCTATTCAAACTTTTTACTGATTCGGACATGCTGGACAACTATGGTCTATCGTTTCTCAACGATACCGATAAGAGAGCCAGTAGCGGTTCGGAGCTAATGACCTATCAGCCTAGTATGTATGATCTCTCTGACATTTTGGACACGgaggacaacaacaagaccaaCCAAGGTGTAGCCAATGGACGCCAATTGCAAACCCAAAGCTCAGTGCTGAATACGCCGCGCCATGAATCGTAG
Protein Sequence
MSKTRASFKAVQLKHESTEEEEDEEEPQQLKRPRRNIMHTVGENVSGSGVPAFLAKLWRLVDDPDTNNLICWSKDGLSFIIQNQAQFARELLPLNYKHNNMASFIRQLNMYGFHKITSIENGGLRFDRDEIEFSHPCFKRNYPYLLDHIKRKISNTKTVDDKSVLKQETVSKVLSDVKAMRGRQDNLDSRFSVMKQENEALWREIASLRQKHAKQQQIVNKLIQFLISIVQPSRNMSGVKRHMQLMINDKPENARKRNASESGSECGPVIHELSEELLDEVMNPNSPYAKHYDADSESPAPMERPRSNMSITSSQNYDYSNQSAEDFINVQLLNSGGEARINAQCSPGGQQELYTVTEAPDSHGQTSPLYNGDEHANVLTTPMVREEEARNRQLLKERNKLRRQTDITVDLDMSPKTTRTRSQAKEQPQIMPQPVLVKAEPAAVNMPSLLDQPESSNADMYNVNFISNDMPTNIFEDDSLLSNTGLDEHVAVQEDQQQQQQQQFGLSTVNSGKFANVPINFDLTNSGNENALVSDANLASTSAAAAAAVKDLGNEQRQQQQKPQSDKQQEQSPAMTVAKYTGDNGHVDEVSGHLDNMQDELESLKDLLRAEGVSIDQNMLLGAAPKGVATRMAPLQLSDEELLFKLFTDSDMLDNYGLSFLNDTDKRASSGSELMTYQPSMYDLSDILDTEDNNKTNQGVANGRQLQTQSSVLNTPRHES