Dkik007809.1
Basic Information
- Insect
- Drosophila kikkawai
- Gene Symbol
- topi
- Assembly
- GCA_018152535.1
- Location
- NW:23495079-23498885[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 0.21 12 6.2 0.7 2 21 148 166 147 167 0.93 2 10 8.9e-06 0.00053 20.0 2.9 1 23 252 274 252 274 0.97 3 10 0.2 12 6.3 0.2 2 23 300 321 299 321 0.78 4 10 0.044 2.6 8.4 0.1 2 23 416 437 415 437 0.96 5 10 0.00094 0.056 13.6 2.9 1 23 484 507 484 508 0.96 6 10 5.2e-07 3.1e-05 23.9 1.9 1 23 567 589 567 589 0.95 7 10 0.00021 0.013 15.7 1.0 1 23 595 620 595 620 0.97 8 10 0.58 34 4.9 2.9 1 23 626 648 626 648 0.88 9 10 7.6e-08 4.5e-06 26.5 0.5 1 23 654 676 654 676 0.99 10 10 0.0014 0.084 13.1 2.5 1 23 682 705 682 705 0.96
Sequence Information
- Coding Sequence
- ATGGATTCCGAGGATTTTGGAAGCCTTCAAGAAGGCGAGCAGCAGGCGGGGGAATATACACTGGCCGAGATTGAGGTCGATATGGAGTCGCAGCTGACTCCCAATGACCTGGACCCCGGTGCCACGGTGCTGCTCTCCATCGAGGGCGACGAAGACGGCGAGCGAATTATGAGCCACGAGGATCTATCCAGGTGGTTTTTGGTAGAGCCGGCCGCAAGCCCGGCACCAATGCCCACAGATGTAGTGGTGCAGCGTACCCTAGAGGACCCAGCTCTCAAGCAGATCCTCCAGGAGGCCGACGGCAAGCCGGACTTTGATCCCGAGGCGGAGCAGATGAAGATACGCAGCTTCCTTGCAGGCATTACGCACAGCAAGATGACCACAGAGCAGTCTGTATTTCAAGGATACCGCCCCAACACAACAGGCTTTGGCAACCGGAGTAAGTGCCCCGATTGCCTTGGCAGTTTCGATGCCTCGTCGTTTCAGAATCACTTGTGCAGCACCGAGGTCGAAAGGAAGTCCAATCAGAAGTCCGTCGCCGAAGCTGTGGCTGACAAGCAGGCGGAGaagccaccagcagcagcagcagcagcacctgaTCCCCCAGCTCCTCCTTCCCCCAGCAAACCGAACAGCATACGAGTGGTGGCAGAAAACCAGATCCGCCTGCGTCGCTTCTTGAATGATGAGCTGAAATACGACATAAACCCCGGAGTGGATGGCTCGAGCAGCCGTAAGTCCGGTAAGGGACTTCACGAGTGCAGCAAGTGCGACCGCAAGTTTGTCCACGCCTCTGGGTTGGTGCGCCACATGGAGAAGCACGTCCTGGACCTAATCCCTTCGCAGAGTAAACCACAGCCGGCCGCATCTCTGGCGGCCGGTCTCACTGCCGTGGTGAAGTGCAACTTCTGTGGACGGATCTTTTACGATCCGCAGGTGGCGTTGGAGCACGCCCACGTTCACTTTGAGGTACATCCAATAGCCAATAGCCAATCGGAAACGGCGGTCAAGTACACCACCAATGTAGATTTTAAGCAGCTTATAAAGGACACGGAGTCGCTGCTGAGCGACGTTTGCTCGGGAGCGGCGAAGCTAGGGAAGCAGAAGAACATGGAGGTGCTGGTGAAGATGGAGAAGCTAGAGAAGCCGGAGGAGCTTAAAAAGCTGGAGAACCTGAAAAAAGTAGAGATCCTGAACAGCCTGGAAGAGAATTTATTTAGCATCTTGGTGCTGGGCAGCGTCCTGCAGTGTGAGTTCTGCGAATACCTGTTCTCCGACATCAGGGAGCTCCTCGCCCATTCGGCCACTCACCCGGTAAAGCGGCGATTCGAGTGCACCGCCTGCGACATTAAGATGGATACTGCCAAGGAGGCCAGACTGCATTTCGAGACGGACTGCATCTTCATGCGCGAGTCGCTGAAGTCGCTAAGCGTTTCGGTCAGCCGCTTCTTTGCGTGCAATGTGTGCGAGCTAAAGTTCGCCAACTCtgagctgctgcaggagcatcGCTGCACCTACCATCACTACTTTCCGCGGCTCAGTCCGCATGGCGCGAGCCTGCTGCTCCCCTGCGAGTTCTGTGAGGTGATATTCGAATCCGCCCGCGAGGTTCAGCCGCACAACGAGGAGAAACACCTAAGCAAGAAGAAACGAGAGAAGGAGACGCGTGGCAGCACGACCAGCGGTCGCCAGCGGCAGTACCTGTGCGACATCTGCGGCAAGTCCTACACCCAGTCGAGTCACCTGTGGCAGCACCTGCGCTTCCACCAGGGTGTGAAGCCCTTCGTATGCCCGGAGGATAAATGCGACCGCAAGTTCACCATCCGACCGGACCTCAACGACCACATCCGCAAGTGCCACACGGGCGAGCGGCCGTTTCACTGTCAGACGTGCGGCAAGCGTTTTCTCACCGGCTCCGTCTTCTACCAGCATCGCCTCATTCATCGTGGCGAGCGGCGTTACGAGTGCGAACAATGTGGCAAGCGATTCTATCGCGCCGACGCCCTCAAGAACCACCAGCGCATCCACACCGGGGAGAAGCCGTTCAGTTGCCTTTTCTGCACCAAGACATTTCGCCAGCGCGGCGATCGCGATAAGCACATGAGGGCCCGCCACGCACACCTCGATGCCAACTCGCGCCTCATGATGCAGATGCAGAAGTTCCAGCTGGAGTCGGCCGCAGCCGCCAAGGCCAAGGGGGAGAAGACCCCGTCCGGAGTTGCGATGGCTGCCTGTGGTAGCCACCCCTTGGCAGAGGGTTTGGAGCCCGGAGAGGTAGTGGCTTCAGAAGAGCATCTGCACGATCCCGAGCCAAACGGAGACATGCCAAACTATTTTGTAGTGGATGAGTATGTGGAGGGTGAGCCTGGGGAGAATGACCTGAACGGTTTCAATATGCAGCAGGGTGTCTGTACCCTGGAAGAGGAGGGCTGCAccatggaggaggaggagcagcagatAATTCTGTACGAGACTCAGCCAGGAAGGGATTTGAACTTGGGAGACGACCAGCAACCAGGACAGGATTTGATCACCTTCGACTATAAGGAGGCTAATGAGGAGCCAATGCAGGACGAGGACTATGTTCAAATGCTTCAGGGCGACGAAAATGCCAGGGTTGTGGTTGTGCAGAACAACCCAGCTCAGCCTATGTTTTCCAATTCCTACATGTAA
- Protein Sequence
- MDSEDFGSLQEGEQQAGEYTLAEIEVDMESQLTPNDLDPGATVLLSIEGDEDGERIMSHEDLSRWFLVEPAASPAPMPTDVVVQRTLEDPALKQILQEADGKPDFDPEAEQMKIRSFLAGITHSKMTTEQSVFQGYRPNTTGFGNRSKCPDCLGSFDASSFQNHLCSTEVERKSNQKSVAEAVADKQAEKPPAAAAAAPDPPAPPSPSKPNSIRVVAENQIRLRRFLNDELKYDINPGVDGSSSRKSGKGLHECSKCDRKFVHASGLVRHMEKHVLDLIPSQSKPQPAASLAAGLTAVVKCNFCGRIFYDPQVALEHAHVHFEVHPIANSQSETAVKYTTNVDFKQLIKDTESLLSDVCSGAAKLGKQKNMEVLVKMEKLEKPEELKKLENLKKVEILNSLEENLFSILVLGSVLQCEFCEYLFSDIRELLAHSATHPVKRRFECTACDIKMDTAKEARLHFETDCIFMRESLKSLSVSVSRFFACNVCELKFANSELLQEHRCTYHHYFPRLSPHGASLLLPCEFCEVIFESAREVQPHNEEKHLSKKKREKETRGSTTSGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEDKCDRKFTIRPDLNDHIRKCHTGERPFHCQTCGKRFLTGSVFYQHRLIHRGERRYECEQCGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHAHLDANSRLMMQMQKFQLESAAAAKAKGEKTPSGVAMAACGSHPLAEGLEPGEVVASEEHLHDPEPNGDMPNYFVVDEYVEGEPGENDLNGFNMQQGVCTLEEEGCTMEEEEQQIILYETQPGRDLNLGDDQQPGQDLITFDYKEANEEPMQDEDYVQMLQGDENARVVVVQNNPAQPMFSNSYM
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00489551;
- 90% Identity
- iTF_00533261; iTF_00489551;
- 80% Identity
- -