Basic Information

Insect: Drosophila innubila
Gene Symbol: wek
Assembly: GCA_004354385.1
Location: NW:22422604-22425713[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0016 0.092 12.8 0.6 1 23 262 285 262 285 0.95

2 8 1.9e-05 0.0011 18.9 0.3 2 23 296 317 295 317 0.97

3 8 4.8e-05 0.0027 17.6 0.1 3 23 328 349 327 349 0.93

4 8 0.14 7.8 6.8 0.6 1 23 355 377 355 377 0.94

5 8 9.7e-05 0.0054 16.7 0.6 1 23 383 405 383 405 0.97

6 8 9.1e-05 0.0051 16.8 0.3 1 23 410 432 410 432 0.98

7 8 2.3e-05 0.0013 18.7 0.1 1 23 438 460 438 460 0.97

8 8 0.0031 0.18 11.9 5.5 1 23 466 489 466 489 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0016	0.092	12.8	0.6	1	23	262	285	262	285	0.95
2	8	1.9e-05	0.0011	18.9	0.3	2	23	296	317	295	317	0.97
3	8	4.8e-05	0.0027	17.6	0.1	3	23	328	349	327	349	0.93
4	8	0.14	7.8	6.8	0.6	1	23	355	377	355	377	0.94
5	8	9.7e-05	0.0054	16.7	0.6	1	23	383	405	383	405	0.97
6	8	9.1e-05	0.0051	16.8	0.3	1	23	410	432	410	432	0.98
7	8	2.3e-05	0.0013	18.7	0.1	1	23	438	460	438	460	0.97
8	8	0.0031	0.18	11.9	5.5	1	23	466	489	466	489	0.98

Sequence Information

Coding Sequence: ATGAAGGGTGGCGCAAATGCTAAAAGCACGGAAGTAACATCAATGGCGGGCACAGAAACATCAGACTGGCATCATTGGTGCCGTCTCTGTGCAAAGGAACATGCTGACAATGTAAATGTGTATTTTAGAGATGGGGATCAGACTTGGACGAGTGTTTTAGCTGTGGCCATTGGTAAATACTTTTGGGTCAATATCAAAATGGAAGATGAACTGAGTAATACACTGTGTAAGAATTGCTACACACTGGTGGAGGATCTCATCGAGTTTTCCGACCGTGTGAATCGTGTACAAACGCTTTTCACCCGGCTACATCAGGCGGGTCCACTAGCCGCACTTAACTACGATGATATTCGACGGGATTGTGGTCTGCTGGCAGTAGAATGGAAGCACTTTAATTCACGGAGTGTGCCCGAAGAGCCACCAATTGATGAGACAGAGGCAGACACATCCGATTGCATTGTTGATGATATGTTGGAGTCCTATGATGAAGATGCAGAAGTAATGGCCGAAATTGAAACTGCCGAAATAGCTGACAACGAAGAAAACGCTTATGAAACTTATGTTGATCATGAAGAGTCCACGGAAGAGGTGTACGTTAAGGACGAAGAACTAACCGAAGAGACACCGACCATACAGGATCCAAAAACTGCCGCGGAGCTCGCTGATAATGATGAGACGACAACTGCAAACGAAGAGGACATTGGGGAGGATACACCAGAAGCCGATGATCTAAGTGAGACTCAAACAGGTGAAAACGATGATGTCTCCCATGAACGTACTCAGTATAAATGCATGTCCTGCAGCAAGGGCTATAAGAAGCCAATGGCCTATAGACGACACATGGCTGAGGTTCACGGCCTGGTTGCCACAGATGTTCCCAACCTCGAGTGCAAACGCTGCAATGCGGTGTTTGCGACAGAGAATCAACTTACTGCCCATTATCGTACTCATATGCCTGCCAAGGACAAGGCGGAAAATGCTTGTAGTTATTGCCCAAAGCTTTTCACGACACCTGCAGCTCTCAAACGCCACGTCATGTTCATACATGAGAATGTCAAGCCTTTTATATGTGACTGCTGTGGCAAAGGTTCGAAGACTATCACAGCACTCAATGAGCACAAACTTGTGCATACCGATGAGTGTCCCTTCGAGTGTCCGGTTTGCCAACGACGCTTCAAAAACTTGGCCAGGCTGAAGATTCACTCCGATACCCATACAAATAATAACTACGTGTGCAACATCTGCGGCTTGAAACTCAATACTCGTCGCACTCTCAACATGCATCAGCTGGTTCATTCGGATGCCAAACAGTATAAATGTGATGTATGCGGTGCTGCCTTTAAACGGGGCAAAACATTGAAGGCTCATCTGATTCTCCATACGGGTATAAGGCCATACAAGTGCAATTTTTGTGGCAAGGATTTTTCCAATGGCTCCAATTGCCGCATGCACAAACGCAAAACACATCCCAAGGAGCTGGCCGAGGAAGAAGCACGTGGCGTAATGCGATCCACGCTGCTTCCCATGATTACAGAGTTAACCGAAGCTTCCAAACGCGTCAAAAAGCCAGCCAAGGCAGGAACAGCGTTTATTCGGTCAAAGGTCACGGAGGAAAGTTCCGAATCTTCCAATACCAACATTGTAGATGAAGAAATGGAGGAGGAAGCTGATGATGAAGTGCTTTACGAGATTGTTGAGGAGTGTTCATAA
Protein Sequence: MKGGANAKSTEVTSMAGTETSDWHHWCRLCAKEHADNVNVYFRDGDQTWTSVLAVAIGKYFWVNIKMEDELSNTLCKNCYTLVEDLIEFSDRVNRVQTLFTRLHQAGPLAALNYDDIRRDCGLLAVEWKHFNSRSVPEEPPIDETEADTSDCIVDDMLESYDEDAEVMAEIETAEIADNEENAYETYVDHEESTEEVYVKDEELTEETPTIQDPKTAAELADNDETTTANEEDIGEDTPEADDLSETQTGENDDVSHERTQYKCMSCSKGYKKPMAYRRHMAEVHGLVATDVPNLECKRCNAVFATENQLTAHYRTHMPAKDKAENACSYCPKLFTTPAALKRHVMFIHENVKPFICDCCGKGSKTITALNEHKLVHTDECPFECPVCQRRFKNLARLKIHSDTHTNNNYVCNICGLKLNTRRTLNMHQLVHSDAKQYKCDVCGAAFKRGKTLKAHLILHTGIRPYKCNFCGKDFSNGSNCRMHKRKTHPKELAEEEARGVMRSTLLPMITELTEASKRVKKPAKAGTAFIRSKVTEESSESSNTNIVDEEMEEEADDEVLYEIVEECS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00558143;
90% Identity: iTF_00507114;
80% Identity: -