Basic Information

Insect: Drosophila innubila
Gene Symbol: ewg
Assembly: GCA_004354385.1
Location: NC:12156760-12163223[-]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.5e-108 1.7e-104 347.7 0.0 1 212 47 257 47 258 0.98

2 4 0.76 5e+03 -3.5 3.5 94 107 375 385 341 421 0.58

3 4 0.065 4.3e+02 0.0 4.6 92 137 449 494 436 506 0.70

4 4 0.5 3.3e+03 -2.9 0.9 2 19 756 773 755 786 0.69

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.5e-108	1.7e-104	347.7	0.0	1	212	47	257	47	258	0.98
2	4	0.76	5e+03	-3.5	3.5	94	107	375	385	341	421	0.58
3	4	0.065	4.3e+02	0.0	4.6	92	137	449	494	436	506	0.70
4	4	0.5	3.3e+03	-2.9	0.9	2	19	756	773	755	786	0.69

Sequence Information

Coding Sequence: ATGCTCGATGATGATATCCAAAGTCTGGCAAcggatgatgaggatgatgagtTGATAAGCAGCGATGGTAGCCTATACGATGGTGATCTCAATACAATAGCTGTCAATGATGATGTCGCCCATCAGCTGGCAGCCGCTGGtccagtgggcgtggcagcggcAGCCGCCATTGCCAGCTCAAAGAAACGGAAACGTCCGCATTGCTTTGAAACGAATCCATCGGTGCGAAAGCGACAACAGAATCGCCTATTGCGTAAATTGCGTGGCATCATCTATGAGTTCACCGGTAGGGTGGGTAAACAggcggtggtgctggtggcAACGCCGGGCAAACCAAATACCAGCTACAAAGTGTTTGGGGCGAAACCATTGGAGGATGTCCTACGGAATCTGAAGAATATTGTGATGGATGAACTGGACAATGCGTTGGCACAACAGGCGCCGCCGCCACCGCAGGAGGATCCATCGCTATTCGAGTTACCCGGCCTGGTTATCGATGGTATTCCCACACCCGTCGAGAAAATGACACAAGCTCAGCTGCGAGCGTTCATACCGCTCATGTTGAAGTATTCAACGGGTCGGGGTAAACCCGGTTGGGGCAGAGAATCAACGCGACCGCCATGGTGGCCCAAGGAATTGCCGTGGGCGAATGTACGCATGGATGCACGCTCCGAGGATGACAAGCAGAAGATCAGCTGGACACATGCACTGCGCAAGATTGTGAtcaattgttataaatatcaTGGACGCGAGGATTTGTTGCCCACATTTGCGGATGATGAGGATAAGGTGAATGCGCTAATCTCACAGTCGggcgatgaggatgaggatatGGAGCAGCTATCGAATACGCCCACCATACAGACAGTGCAAACGGTGACGCCGGCAGTGACCACCACcaacagtcacagtcacagtcaaCCACAACAGGTGAATGTGGTGAAGATCAACAGCGCCGGTACAGTGATCACCACACACACGGCCCAAACGAATACGCCGGCACCAACAATAATTCAGAGCACGAACAATCAACATGtgacaaccacagcaacattGCCGGCATCCACAAAGATTGAGATATGTCAGGCGCCagcaccacagcaacaacaacaacagcagcaccatcaacagcaacaacagcaacagcaacatcatcatcaacagcaacatcatcagcagcatcatcagacaacaagtggcagcaacacgGTGCACATACAGGCTGTGAGTCAAGGTCAACCGCAGACCATACAATTGACAACGGCGAGtggcacagcaacagcaacggcggtgtcaacgacagcagcagctgtaagcgcatcagcagcagctgcagcagtcgcacaacaacagcaacaacaacaacaacagcagcagcaacaacaacaacaacaatcgaatGCTGCCCAAACAGTCACCGCCCAACAGATCGCCAATGCCCAAGTTTGCATCGAGCCCATAACGCTCAGCGACGTTGATTACACCACACAGACCGTGCTATCGCAGAATGCAGATGGCACTGTATCCCTCATCCAGGTGGATCCCAATAATCCCATCATCACACTGCCGGATGGCACAACCGCCCAAGTCCAGGGCGTGGCAACGctgcatcaAGGAGAAGGTGGCGCCACCATACAAACGGTACAAAGTCTCACTGATGTGAATGGCCATGAGAATATGACGGTAGATCTAACCGAAGCACAAGACGGTCAAATCTTTATTACCACCGAGGATGGACAAGGTTATCCCGTGTCCGTGAGCAATGTGATTTCGGTGCCCGTTTCCATGTATCAATCCGTGATGGCGAACATGCAACAGATTCATAACAGCGATGGCACCGTGTGCTTGGCCCCTATGCAGGTagatagcaacaacagccacagcaacagcaatgcaacacgcggcagcagcagcaacaacaacaacacacacaacatcaatagtagtagtagtagtagtagtagtaataGTAGTGGCAATACATCGTTGCTTGGCATTTCTGTAGTCAATGCCAGTGGCATGTTGGGCAgacgcactgcagcagcagcagcagcaacaacgacaacagctgctgctgctgcagcggcaACTCAACCGGCTGCCATCACGTTGCAAGCGCCGCCGGGCACACGCCTCTATTGggcagctgcagcggcagcaaGTGGCAACAATGCCAGCTCAAGCTTTAATCTcgctagcaacaacaataacaatagcatgcttactaacaacaataacaacaacaacaacattaaaatgcCGCTGCCCATTGTTGTGGCAGCgccagcagcgacgtcgactgcgCAGCATCGTCGCAGTCGGTCGGCAACAGCGCAAAAGCGTCGCAGGCAGACAAGTGGCAAcagcactaacaacaacaataacaagttgTCGTGTGGCAAGAGCAGTGCTGCTGCCACTGATGCTGCAGGCagcgctgcctctgctgccaTACGCTGCGTCGACAGCGCGAGTTTAACAAAtgcgcagctgcagctgccagCAAAAACCATTAAGCTGGAGCATTTGGAGTAA
Protein Sequence: MLDDDIQSLATDDEDDELISSDGSLYDGDLNTIAVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQEDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMEQLSNTPTIQTVQTVTPAVTTTNSHSHSQPQQVNVVKINSAGTVITTHTAQTNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQQQQQHHQQQQQQQQHHHQQQHHQQHHQTTSGSNTVHIQAVSQGQPQTIQLTTASGTATATAVSTTAAAVSASAAAAAVAQQQQQQQQQQQQQQQQQSNAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTEAQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQIHNSDGTVCLAPMQVDSNNSHSNSNATRGSSSNNNNTHNINSSSSSSSSNSSGNTSLLGISVVNASGMLGRRTAAAAAATTTTAAAAAAATQPAAITLQAPPGTRLYWAAAAAASGNNASSSFNLASNNNNNSMLTNNNNNNNNIKMPLPIVVAAPAATSTAQHRRSRSATAQKRRRQTSGNSTNNNNNKLSCGKSSAAATDAAGSAASAAIRCVDSASLTNAQLQLPAKTIKLEHLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00594986;
90% Identity: iTF_00506597; iTF_00575312; iTF_00518899; iTF_00528537; iTF_00537246;
80% Identity: -