Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.3e-06 0.00022 21.5 1.2 2 23 115 136 115 136 0.97

2 6 2.1e-06 0.00014 22.1 2.3 1 23 142 164 142 164 0.98

3 6 0.00028 0.018 15.4 4.9 2 23 171 192 171 192 0.97

4 6 0.00063 0.042 14.3 2.6 3 23 200 221 198 221 0.95

5 6 0.00015 0.0096 16.3 0.6 1 23 235 258 235 258 0.96

6 6 1.4e-06 9.2e-05 22.7 0.4 1 23 264 286 264 286 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.3e-06	0.00022	21.5	1.2	2	23	115	136	115	136	0.97
2	6	2.1e-06	0.00014	22.1	2.3	1	23	142	164	142	164	0.98
3	6	0.00028	0.018	15.4	4.9	2	23	171	192	171	192	0.97
4	6	0.00063	0.042	14.3	2.6	3	23	200	221	198	221	0.95
5	6	0.00015	0.0096	16.3	0.6	1	23	235	258	235	258	0.96
6	6	1.4e-06	9.2e-05	22.7	0.4	1	23	264	286	264	286	0.98

Coding Sequence: atgcttaaaGTGCAAAACAATAGTGAGAAATGCGCAGAAATCTATTGCAACGCTTTGGCAGAGCCCAAATTCAACATTATGTGCATATGTGGCAAGTCCATAGCGGAGTACGAGGCATTTTGCGAGCACTTTTACAACGAGCATTTGCGGGAAACAGAAAAGCGCAAAGATCAGGATCAACAACAGCCACCTGATGATGCTGAGCCCGCGAACACTGACGAGTGTCTGGCGGAAGCGCAACTAGTGCTGCTGCCCGCCATAGACGGCGAACACGATACGCTGACAGGCAGCCAACAGGAGACGAATCCGAGTACGTCCAGGGAACGCAAGAAGCCCCAAAACACATGCAGCTATTGCGGACGCAGCTTTCGACGGCGTCAGCTGCTGGACACACACCTGAACATACACACGGGCAGCAAGCCGCATCAGTGCGAGACGTGTGGCAAGCAGTTTCGAGCCGTATCCACGTTGATGCGTCACCTGCGCACGCATCAGGAGCGCCAGCAGGAACAGTGTCAGCATTGCGAGAAACAGTTTACGCATCGCAGTGCGTTGCTCAGCCACGAGCTTCGGCACACGCAGCAGCGACGCTGGGCCTGCGGCAGCTGCGACAAATGCTTCTATACGCGCAACCAAATGGATACGCATCAACGCAAGTTGCATGACAAGAGCAGCACTGTCGCCTCGTCCAGCCATTTGCCCTTTGCCTGCGAGCTGTGTGGGAATAGTTATCGCAGCGCATCCATGCTGAGCACGCACCGACTGAAGAAGCATTATCGTTTGGCCAAATACCAGTGCGAGCAGTGTGATAAGAAGTTTGTGGATGCCGAGCGCTTGCAGCAGCACCAActaatacatacaaaaaagtctgattgttaa
Protein Sequence: MLKVQNNSEKCAEIYCNALAEPKFNIMCICGKSIAEYEAFCEHFYNEHLRETEKRKDQDQQQPPDDAEPANTDECLAEAQLVLLPAIDGEHDTLTGSQQETNPSTSRERKKPQNTCSYCGRSFRRRQLLDTHLNIHTGSKPHQCETCGKQFRAVSTLMRHLRTHQERQQEQCQHCEKQFTHRSALLSHELRHTQQRRWACGSCDKCFYTRNQMDTHQRKLHDKSSTVASSSHLPFACELCGNSYRSASMLSTHRLKKHYRLAKYQCEQCDKKFVDAERLQQHQLIHTKKSDC

Sequence clustering based on sequence similarity using MMseqs2