Basic Information

Insect: Drosophila immigrans
Gene Symbol: topi
Assembly: GCA_963583835.1
Location: OY757142.1:9086251-9088751[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 3.3e-06 0.00022 21.5 0.8 2 23 225 246 225 246 0.97

2 9 0.023 1.5 9.4 0.1 2 20 272 290 271 293 0.87

3 9 0.017 1.1 9.8 0.1 2 23 355 376 354 376 0.95

4 9 0.0056 0.37 11.3 0.3 1 21 423 443 423 447 0.90

5 9 4.9e-07 3.2e-05 24.1 1.9 1 23 513 535 513 535 0.95

6 9 0.00064 0.042 14.3 0.7 1 23 541 566 541 566 0.96

7 9 0.42 28 5.4 1.7 1 23 572 594 572 594 0.88

8 9 3.7e-08 2.4e-06 27.6 0.4 1 23 600 622 600 622 0.99

9 9 0.00068 0.045 14.2 1.8 1 23 628 651 628 651 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	3.3e-06	0.00022	21.5	0.8	2	23	225	246	225	246	0.97
2	9	0.023	1.5	9.4	0.1	2	20	272	290	271	293	0.87
3	9	0.017	1.1	9.8	0.1	2	23	355	376	354	376	0.95
4	9	0.0056	0.37	11.3	0.3	1	21	423	443	423	447	0.90
5	9	4.9e-07	3.2e-05	24.1	1.9	1	23	513	535	513	535	0.95
6	9	0.00064	0.042	14.3	0.7	1	23	541	566	541	566	0.96
7	9	0.42	28	5.4	1.7	1	23	572	594	572	594	0.88
8	9	3.7e-08	2.4e-06	27.6	0.4	1	23	600	622	600	622	0.99
9	9	0.00068	0.045	14.2	1.8	1	23	628	651	628	651	0.95

Sequence Information

Coding Sequence: ATGGATGGAGATTTGAATTTGTGTGAGGGCGGCGAATTTGTCATGGCCGAGTTCGAGTGCGATACGGAATTCGTGGTCGATCGCAGCTGTGAACTGCAGGAGGGAGCCACAGTGCTGGTGGCCAACGAGAGCGATGGCATTGTTAACTTTGAGGATCTCGGCAAGATTTTTGACATCGCGAACGTGATACAGATTGAGGCGGAAGATGCCGTTGAGCGCACGCTGGCGGATCCGGATTTGAAACAAATCCTACAAGAAGCCGAAGACAAGGTGGATTTTGATCCGGAGGCGGAGCAGGAGAAGCTGCGTGACTTTCTGGTGgaggccaacaacaaaatagtcAGTCAGAAGAGCATTCCTATAGTGCCAAGTGCTGCCTTCAAGCAGCCGGTGAGCATCATCAAGTGCTCCAATTGCACTGGCCTGTTTCATTCCACCGCTTTTCAAGAGCATCGCTGTGACATTCTAGTCAATCCAAAGCCAACTACGCCAAAGCTGCCGCCAACTGCCATTACAGACAAGCCTGTGCCGCCCAAGAAACTGCCTAGCGAGCGCATTCTCATCGAGAATCAGGTGCGCATACGTCGCTATGTCAAGGAGGAGCTCAAGTACGATCTGGAGACGGGCGTGGACAGTTCCAAAGTGAAAAAATCCTCCGCCAAGGGGCCCAACGAGTGCAACATTTGTGATCGCAAGTTTGTGCACGCCTCCGGCTTGGTGCGTCACATGGAGAAGCATGCGCTGGATCTGATACCCAAGCAGTCGAGTGTGCAGCACTCGGCGCTGTCTGCGCTTGGTCTGCTGGTGGTGCTCAAGTGCAATAAGTGTGGACGCATCTTCTACGATGCCAAGTTAGCGCTCGATCACATTCCCGTTCACTATCCACAGCCAGCGCCGACAAATAAGTCCTGTGTGGTCAAGGAAACGGAAGCGGAGTTGAAGCGACAACTGGATGCGCTGCTCGTGGAGGGTCAACAGCTGCTGGCGGTCAACATGCAGCTGGAGAAGCTGCAGCGCTACGAGCACGAATTGTTTTCCTCGCTCATCCTCAGTCATGTGCTGCATTGCGAGTTTTGCGACTACATCTTTGCAGACATCTCCAGCCTGCTGGGGCATGCGGCCACTCATGTGCCCGAACGTCGCTTCGAGTGCTCCGCCTGCAATCTGCTGATGACCACCGCCAAGGAGGCCAGTGTCCACTATCAGACGgagtgtgtttacatgagGGAAGGCCTCAAGCAGCTGCAGATGTCGCCCAATCGCTACTTTGTCTGCAATGTGTGCGAGCTCAAGTTTGGCAACGCGGAGCTGCTCCAAGAGCATCGCTACAGCAGTTATCACTACTTCCCGCGTCTCAGCGAGTCGGGAAAACGTCTGCTGCTCCCTTGCGAGTTCTGTGCTTGCAACTTTGAGTATGCCCATGAGATCCAGCCGCATTACGAGGAGAAGCATCTGAATAAGAAGAAACGTGAGAAGGAGTTGCGGCACAATAGTAATGGTAATGCGGGCAGTGCTCAGGTGGGTCGCTTGCGTCAATATCTCTGCGACATTTGCGGCAAGTCCTACACCCAATCCAGCCACTTGTGGCAGCACTTGCGCTTCCATCAGGGTGTCAAGCCCTTTGTGTGCGATGAGCCGGGTTGCGGACGCAAGTTCACCATACGGCCGGATCTCAATGATCACACCCGCAAATGCCACACGGGCGAGCGGCCGTATCACTGTCTGGTGTGTGGTAAGCGCTTCCTTACCGGCTCCGTGTTCTATCAGCATCGGCTCATCCATCGTGGCGAGCGGCGCTACGAGTGTGACGAATGCGGCAAGCGTTTCTACCGTGCGGATGCCCTGAAAAACCATCAACGTATTCACACCGGCGAGAAACCTTACGACTGCCAGTACTGTACCAAGACTTTCCGGCAGCGTGGCGATCGGGATAAGCATGTGCGAGCACGTCACTCGCTCCTGGATGAGAATGCCCGGCTGATGATGCGCATGCAAAAGGTTGAGCTGGAAACGGCGGCGGCGCTGAAGGCCAAGCAAATGCAGGAGAGCAGCAGGGATGAAGAATCCCTCACAGATGTCTCTCAGCTACCGCAAGCTGGCCTGTTGACCGAGCAGCAGTACGATATGGTTGAGCTGGATCCCAATGATTATTGCGAGGCATCCGAGTTTGATCAGGTGCAGCTGGCGATTGATAATCCCGAGTATCAGGTGATTACGTATGGCACGGCAGAGTCTATGGAGCCGGTGAAAGTGCCACAGTTTACGCGTGACAACGCTAGAGTTGTGGTTGTTGAGAATAATGCTTCGCAACCGTTTTATTTCTAA
Protein Sequence: MDGDLNLCEGGEFVMAEFECDTEFVVDRSCELQEGATVLVANESDGIVNFEDLGKIFDIANVIQIEAEDAVERTLADPDLKQILQEAEDKVDFDPEAEQEKLRDFLVEANNKIVSQKSIPIVPSAAFKQPVSIIKCSNCTGLFHSTAFQEHRCDILVNPKPTTPKLPPTAITDKPVPPKKLPSERILIENQVRIRRYVKEELKYDLETGVDSSKVKKSSAKGPNECNICDRKFVHASGLVRHMEKHALDLIPKQSSVQHSALSALGLLVVLKCNKCGRIFYDAKLALDHIPVHYPQPAPTNKSCVVKETEAELKRQLDALLVEGQQLLAVNMQLEKLQRYEHELFSSLILSHVLHCEFCDYIFADISSLLGHAATHVPERRFECSACNLLMTTAKEASVHYQTECVYMREGLKQLQMSPNRYFVCNVCELKFGNAELLQEHRYSSYHYFPRLSESGKRLLLPCEFCACNFEYAHEIQPHYEEKHLNKKKREKELRHNSNGNAGSAQVGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCDEPGCGRKFTIRPDLNDHTRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCQYCTKTFRQRGDRDKHVRARHSLLDENARLMMRMQKVELETAAALKAKQMQESSRDEESLTDVSQLPQAGLLTEQQYDMVELDPNDYCEASEFDQVQLAIDNPEYQVITYGTAESMEPVKVPQFTRDNARVVVVENNASQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00595450;
90% Identity: iTF_00509303;
80% Identity: -