Basic Information

Insect: Drosophila hydei
Gene Symbol: fru
Assembly: GCA_003285905.2
Location: NW:877049-1055101[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.59 33 4.7 0.1 2 23 1100 1122 1099 1122 0.89

2 6 0.0012 0.067 13.2 0.9 1 23 1133 1156 1133 1156 0.92

3 6 0.00051 0.029 14.4 2.7 1 23 1166 1188 1166 1188 0.97

4 6 5.9e-06 0.00034 20.5 2.1 1 23 1488 1510 1488 1510 0.97

5 6 7.4e-06 0.00042 20.2 0.2 1 23 1516 1538 1516 1538 0.98

6 6 3.3e-05 0.0019 18.1 4.2 1 23 1544 1566 1544 1566 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.59	33	4.7	0.1	2	23	1100	1122	1099	1122	0.89
2	6	0.0012	0.067	13.2	0.9	1	23	1133	1156	1133	1156	0.92
3	6	0.00051	0.029	14.4	2.7	1	23	1166	1188	1166	1188	0.97
4	6	5.9e-06	0.00034	20.5	2.1	1	23	1488	1510	1488	1510	0.97
5	6	7.4e-06	0.00042	20.2	0.2	1	23	1516	1538	1516	1538	0.98
6	6	3.3e-05	0.0019	18.1	4.2	1	23	1544	1566	1544	1566	0.98

Sequence Information

Coding Sequence: ATGGGCAGTGAGCAATACTGCTTGAGGTGGAACAATCATCAATCCAACCTGTTAGGGGTGTTTAGTCAATTATTACAGGACGGGAGCCTGGTGGACGTTACATTAGCTTGTTCAGGGGGCCCATCCATCAGAGCCCATAAGGTGGTGCTGTCGGCCTGCTCCTCGTATTTCCAGAGCCTGTTTCTGCAGCACTCCGATCCACATCCAATTGTGATACTGAAGGACGTCCGTTTTGCCGAGCTGCAAACTCTAGTTGAATTCATGTACAAGGGCGAGGTGAACGTGCAATATTGTCAGTTGCCAGCGCTGCTCAAGACAGCCGAATCACTGAAGGTTAAAGGCCTAGCCGAGATGACAAATCAGAACACGACGCTGCGGGAGCCCGAGCGGGAGCCAGATCGCCTGCGTCCCCATTCGCAggccagcggcggcagcggcagtggcagcaaggCGGCCGACAGTCCACtggacgcagcagcagcagcagcagcggcggtgTCAGCTCCCAGCTCTTCAACAGccacgacagcagcagcagcagcagcagcgacagcagctgcaacgacagcaacaacagcagcagcagcagcggacaATATGGCGacaacagctgctggcagcagtaaaacagcagcaacagaaacaacaacagcagcaacaacaaccacagcaacagcaacaagcacagcaacaacagcagcagaagcagcagcagcagcagcagcagcgtcaacgTCAGCTGCGTCCGAGGCGTCAGCAGCGACGTCCGCGTCGAAGCGCGAGGCCGGCGAACGCTGCAGTCCGACGCCGCCGCCAAAGCGgccagcgagcagcagcacagcagccaTTGAGCTGCtggaggacgaggacgaggatgacgacgatgatgctGAGGAGCTgctggaggaggaggacgatGAGCTGGTGGAGGAGCTGGAAGAGGATACATCAATGCCGCTAGATCTTTATCAAAGacccgccgccgccgccacagcTGCGTCCGCTGAGCCACATGCCATGCCGCCAGAGAGCTCTAcgagcagccacagcagcagcaacaacaacaacaacaacaacaacaacaacggcagcagcaacaacaacagcagcagcaagaatagcagcagcaacaacaacagcagcagccacaacaccagcagcaacaacaacaacaacaatagcagcaacaacagcagcagcaacaaccaaatGAAAGCCACGTGCTCCTCCTCAACGGGCGCCTCGcccagcggcagtggcagcaacggcaacggcaacgtcaacgtcaacgccAACGACTGCACAGCGCATGCAACGCCCGAGCCGAGCAGCCATGTCGTGGCCGTTGACattgatgacgacgacgaggacgagcCGGACGATCATGATATGACCGATGTGGATGATCACGTCATCGTTGTCCATCGaactgcggcagcagcagctgcagccgctgcacgCGACATCGCGCAACGCATCGCGCATCACAGTGCGCGGCGTGCCCAGACCGAgaacgatgacgacgacgacgatgatgatgatgacgatgaggaCGATGATGAGCATCGGCACGATCAGCCAGCAACGtcggccgcagcagcagcagcagcagcggcagcagcagcagcagcgcatgaATCGCTGCTTCACTCGCCCAGCGCCAGCGGCGGGCTGCAGCCGAAGACAGAGGTGATCGACGATGACTACGACGACGAGATGGATCtggacgacgacgatgaggcggacaacagcagcaacgagaTGGGCCTCAACATGAAGATGAGCAGCGGCGGTGTCGATCTCTCTACGGGCTCTACCGTTATACCATCACCGCTAATCTCGATGCCCTCatcgtcggcagcagcagccgccgcagcagccgcagcagcagcagcagccgccgccatGGAATCAGCTCGCTCCACAcctggcggcggcggcggcggcggcggcaatgCCGTTGCCTCCGATCTGAGTCTGTCGATGTCGCAATCCGGACGCCCATCGTCGCGTTCATCGCGCGACGGCAGCAACGCCGCTGCCGACGGACGCTCCAGCAGCCTCCTGAATCCCGGCAACGTAGCCGGCCTCTTGCCAGTGCAATCGGTGCCATTGAGCCTCAAGAAAGAGATCGATTGCAGTGAGGATGATAACAGCAGTCACAGTAGACACATGCAACCGCGTTCGGCATCAGCTGGCGGCGGACTGGGCGGCGACCTGGACTATCGCGCCTCGCACGAATCGCTGCTGCGCAACTTTGGCTCACCGATGAGCGCGATGGCCGCCAGCCGCTGCCCCACGCCGTTTGCGTTCCCCTTTTCGCCGCTCGGGCTGAGCCTGTTCGACATTGATCCGTCCAGAATACTGAACCTGCTGCACCACCAGACCTGGCTGGCCGAGGAGGCATTGCGCACGCGCGGCCTGCTCGGCGCGCCAAAGGACTTTCCCCACCGTTTTACCACGTTGAGCGATCTGCTTACCAAGGACTATCAGCCAACGGCGGCCAGCTATGCGGCCAAGCAGACGCAGCAGTCCACAACGAGCCGTTCCAGCGATCCACAGTACAAACAAccgcagcaacatcagcaacaccagcaacaaccacaggccacacagccgcagcaaccgtctcagcaacagcaacaatcaggACAAGCGGCGCAGCCGCATGTCGCGTTCAATATGCgctatgccacgcccactggcttTTTTCAGCCATCGAAGGGCGGCAAGTCGGCAGGCACACCCTCGCCACAGCAGATGGCCACCTCGTCGACGGCCATCTCAGCGGAGTCGCAGCTGGAGGGCCAGGCGGAGGGCAACGATGACGTCACCATCGTTGAGCTGGGCAGCGAGCGCAGCGTCGTGACGCCCAATAGCAGTGCGCTGCTGTACAAGGAGtcgctggagcagctgctggcccagcagcagcagcaccagcagcaccagcagcaccaacagcagcagcagcagcagcgacgtcgcAATGCTAACAACAGCACGTCCAGCACAGGCGGagttggagctgcagctggagctggcagTGGAGCTGGGGTCATTGTGGACGCCAGTGGCTTGCGTCAATatacgcagctgctgctgtctggtGCTGGCACGCCCGTCAGCTGCACGGACACTTCGAGCAGCTGCAAGGAGAAGAGCTCCTCGTCGTCTACCTCATCGACGCCGCCGCCAAGCGGCGCGCTGCTCGcccagcatcagcagctgagCCAAATGCTGAAGAGTCCATCGGACACGTGCTCCTCGCTGTTCAGCGAGCCGATCGAGGAGGAGACACGCTGCGTCGTCTGCAATGCGCACTTCCCCAACGTCTGGCTGCTGGAGCAGCACGCGGCACTGCAGCATCCGCACATCGGGCCGGGCGAAGAGAAGCCCTTCATATGCGAGCAGTGCGGCCAATCGTATCGCTATCGCAGCGCCTATGCCAAGCACAAGGAGCAGAACCATCGCGCCCGCCTGCCCGCCGACAAGCTGTTCACCTGCGACGTCTGCGGCATGCAGTTCCGCTATCTGAAGAGCTTCAAGAAGCATCGGCTCAATCATGCACTCGAGCGTCTCCATGGCAAGAAGTCGATTGGCGTCGGCGTTGGCGTGGGCGttggtgtgggcgtggcacgcaTGATAAGCGgcacagcggcagctgcagcagcagcagcagccgccaccaCGGCACAGCTGGACCAGGATGTGGTGACCAGCTCGCAGGAGCCGATGCTGGCCGACGAGGGCGAGGATCTGCGCATCAATGTGAAGCGTGAGGGCGACGACCCGGCCCACCAGCAAGAGGCCACCAGCGAGGAGCACGAACAGGACAACACAATCGACTCGGCGGGCATCACGATGCtctacaacgacaacaactcaTCGGCTTCGGCCTCCACGAGCGCCACGGAGCCGAACATCAGCAGCTCGGACGGCATACATAGTACAAACAAGCGGTCACGCCTGTTGAACAGCGCACACCACTTGGAAACGGATCCCTCCTATCACCATCAGCcacaccatcatcatcatcaatcacaacagcagcagcagcagcagcagcagcagcagcaacagcagcagcaacagcagcagcagcagcaacagcatcatcatcagcagccgcagtcgcagtcccagcagctgccgccgcatCTGGCGCACGTCTCACTGCCAATGGCCAGCGCTGCAGCCGGCTCctcgtcggcagcagcagctgcggcggcCGCTGCGGCTGGCTGCATCGCCAGTCCAGGGGCTGGCGCAGCTGGCTCTGCCAACAGCGGCGTGGGCGGCAGCGGCATTAGCTCGCTCAGTTCGCTGACTTCGCTGATCAATGCGGAGCGCATACCCAATGAGCAGTTCCTGGGCCTCAATCCGCAGGAGGCTTCAATACTCAACTTTTTGCGAGTCGATGCCGCTGAGCGACAGCGTGACAAGCGACCCACCACATCGCGCTTCGCATGCCCCTTCTGTGGCAAGTGCGTCCGCTCCAAGGAGAACCTGAAGCTGCACGTGCGCAAGCATACAGGAGAACGTCCGTTTGTCTGCCTGTTCTGCGGACGCGCCTTCGGCGGCAAATCGGATCTGACCCGCCATCTGCGCATCCACACCGGAGAGCGGCCGTACCACTGCGAGTCGTGCGGCAAGTGCTTCGCCCGGGCCGACTATCTCTCCAAGCACTTGACCACGCACATTCACAATGCGCCGCGCTGA
Protein Sequence: MGSEQYCLRWNNHQSNLLGVFSQLLQDGSLVDVTLACSGGPSIRAHKVVLSACSSYFQSLFLQHSDPHPIVILKDVRFAELQTLVEFMYKGEVNVQYCQLPALLKTAESLKVKGLAEMTNQNTTLREPEREPDRLRPHSQASGGSGSGSKAADSPLDAAAAAAAAVSAPSSSTATTAAAAAAATAAATTATTAAAAADNMATTAAGSSKTAATETTTAATTTTATATSTATTAAEAAAAAAAASTSAASEASAATSASKREAGERCSPTPPPKRPASSSTAAIELLEDEDEDDDDDAEELLEEEDDELVEELEEDTSMPLDLYQRPAAAATAASAEPHAMPPESSTSSHSSSNNNNNNNNNNGSSNNNSSSKNSSSNNNSSSHNTSSNNNNNNSSNNSSSNNQMKATCSSSTGASPSGSGSNGNGNVNVNANDCTAHATPEPSSHVVAVDIDDDDEDEPDDHDMTDVDDHVIVVHRTAAAAAAAAARDIAQRIAHHSARRAQTENDDDDDDDDDDDEDDDEHRHDQPATSAAAAAAAAAAAAAAHESLLHSPSASGGLQPKTEVIDDDYDDEMDLDDDDEADNSSNEMGLNMKMSSGGVDLSTGSTVIPSPLISMPSSSAAAAAAAAAAAAAAAAMESARSTPGGGGGGGGNAVASDLSLSMSQSGRPSSRSSRDGSNAAADGRSSSLLNPGNVAGLLPVQSVPLSLKKEIDCSEDDNSSHSRHMQPRSASAGGGLGGDLDYRASHESLLRNFGSPMSAMAASRCPTPFAFPFSPLGLSLFDIDPSRILNLLHHQTWLAEEALRTRGLLGAPKDFPHRFTTLSDLLTKDYQPTAASYAAKQTQQSTTSRSSDPQYKQPQQHQQHQQQPQATQPQQPSQQQQQSGQAAQPHVAFNMRYATPTGFFQPSKGGKSAGTPSPQQMATSSTAISAESQLEGQAEGNDDVTIVELGSERSVVTPNSSALLYKESLEQLLAQQQQHQQHQQHQQQQQQQRRRNANNSTSSTGGVGAAAGAGSGAGVIVDASGLRQYTQLLLSGAGTPVSCTDTSSSCKEKSSSSSTSSTPPPSGALLAQHQQLSQMLKSPSDTCSSLFSEPIEEETRCVVCNAHFPNVWLLEQHAALQHPHIGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFKKHRLNHALERLHGKKSIGVGVGVGVGVGVARMISGTAAAAAAAAAATTAQLDQDVVTSSQEPMLADEGEDLRINVKREGDDPAHQQEATSEEHEQDNTIDSAGITMLYNDNNSSASASTSATEPNISSSDGIHSTNKRSRLLNSAHHLETDPSYHHQPHHHHHQSQQQQQQQQQQQQQQQQQQQQQQQHHHQQPQSQSQQLPPHLAHVSLPMASAAAGSSSAAAAAAAAAAGCIASPGAGAAGSANSGVGGSGISSLSSLTSLINAERIPNEQFLGLNPQEASILNFLRVDAAERQRDKRPTTSRFACPFCGKCVRSKENLKLHVRKHTGERPFVCLFCGRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLSKHLTTHIHNAPR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00520000; iTF_00479558; iTF_00479719;
90% Identity: iTF_00520000;
80% Identity: iTF_00520000;