Dhet002640.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila heteroneura
Gene Symbol
-
Assembly
GCA_035042245.1
Location
JAWNLO010000207.1:286632-287882[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.12 7.3 7.2 3.0 1 23 140 163 140 163 0.87
2 9 0.0005 0.032 14.6 0.4 1 23 170 193 170 193 0.96
3 9 0.092 5.9 7.5 2.4 1 23 200 225 200 225 0.95
4 9 2.1e-06 0.00013 22.1 1.6 1 23 236 259 236 259 0.98
5 9 0.013 0.84 10.1 7.8 1 23 275 298 275 298 0.96
6 9 0.0027 0.17 12.3 1.4 1 23 306 328 306 328 0.98
7 9 6e-06 0.00038 20.6 0.7 2 23 334 356 333 356 0.95
8 9 2.3e-05 0.0015 18.8 2.7 1 23 362 384 362 384 0.96
9 9 8.8e-07 5.6e-05 23.3 0.9 1 23 390 412 390 412 0.98

Sequence Information

Coding Sequence
ATGCAAGCGCTGAGTAACAACAATTGCTTGACGTGCCTGCACAAAATCGAAAACGACAGCGTTGAGGCGACGAATGCCAACGATGTGCAGATGCAGCGTCTGCTAATGCAGCTGCTCGACTGGCAGCAAGCCGAACTCGCCTCGGACCAGTTGCCCCAACGCTTGTGCGGCACATGCTGCCAGTTGCTGCAGCGTTTCGAACAATTTCAGCAACAGGCACGCATATGccggcaacagctgctggacagcctacagcagcagcagaagccacaACCAGCCGGTTTTGAGATTATCTACGATGAGGAAACTGCGATGCCAACATCCGAACAGCTACTGGAGGCGCCTCATCCAACACCCGATCCATTTGATGATGACACAGGCAAGTCCAAGCGCTGCCCGAGTGCGACGAAGAACAATTTCAAGTGCATGCAATGTGGTCATTCCTTTGCCCGCCGCCTAACCCACGATGCCCACGTGCGGAAGGTCCACGAGGGCAACAAGCGTCCGTTTCAATGCGATCGCTGCGACAAGGCCTACAGCTTTATGGGCGGCCTCTATACGCACATCAAGGAGCTGCATGGCAGCGGGGTGCGTTCGCATCGCTGCGATTATCCCGGCTGCGAACGTGTCTATGTCAGTCGCATTGCgatgcacaaacacaaacgacTGAAGCATCAACAGCCAACGCCGGCCTCCACACGGAAATATGTGTGCGAACAGTGCGGCGCCACCTTTAATCAGACAGCGAATCTGAAGCATCATCGTCGCATCAAACATCCCACAGCGGCGGAGGCAGCCGCCAATGCCAGCGATAGCGTTCAATATTATTGTGATCTGTGCCAGAAACATTTTCATTCGCGTTACACCCTGAAATATCATCGGATGCAACAGCATACGGATGCAGACAAGGAGCGGCACGAGTGCCGTGTCTGTGGCCGTCGAATGGCCAAGCGTTTCATGCTCATCCAGCACATGCTGACGCACAGTGCCGAGAAGACGCCCTGTGAGCATTGCGGTCGTCTCTTCACCCGCAAATTCGAGCTGGAATCGCACATTCGGGCCGTCCATCTCAAGTTGAAGCCATTCACCTGCAGCTACTGTGACGAATCGTTTGCGTCCCGCAAAACGTTGCAACATCACGAGTACATCCATACGGGCGAGAAACCCTACGTTTGCCCCATCTGCGGCCAGGCATTCCGCCAGCAGACGTGCCTCAAGAACCATGGCAAAATCCACGACAAGTCCAAGTGA
Protein Sequence
MQALSNNNCLTCLHKIENDSVEATNANDVQMQRLLMQLLDWQQAELASDQLPQRLCGTCCQLLQRFEQFQQQARICRQQLLDSLQQQQKPQPAGFEIIYDEETAMPTSEQLLEAPHPTPDPFDDDTGKSKRCPSATKNNFKCMQCGHSFARRLTHDAHVRKVHEGNKRPFQCDRCDKAYSFMGGLYTHIKELHGSGVRSHRCDYPGCERVYVSRIAMHKHKRLKHQQPTPASTRKYVCEQCGATFNQTANLKHHRRIKHPTAAEAAANASDSVQYYCDLCQKHFHSRYTLKYHRMQQHTDADKERHECRVCGRRMAKRFMLIQHMLTHSAEKTPCEHCGRLFTRKFELESHIRAVHLKLKPFTCSYCDESFASRKTLQHHEYIHTGEKPYVCPICGQAFRQQTCLKNHGKIHDKSK