Basic Information

Insect: Drosophila helvetica
Gene Symbol: ush
Assembly: GCA_963969585.1
Location: OZ018402.1:3122617-3130155[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.007 0.67 11.0 0.0 1 20 225 244 225 246 0.90

2 9 0.0003 0.029 15.3 0.8 1 23 305 327 305 327 0.98

3 9 0.054 5.1 8.2 1.0 2 21 380 399 380 400 0.92

4 9 0.052 5 8.2 2.9 2 21 794 813 793 814 0.93

5 9 0.0096 0.92 10.5 0.0 3 21 862 880 860 881 0.91

6 9 0.007 0.66 11.0 0.0 2 23 949 970 948 970 0.98

7 9 0.0041 0.39 11.7 1.3 1 23 976 998 976 998 0.99

8 9 0.00074 0.07 14.0 0.8 1 23 1060 1083 1060 1083 0.96

9 9 0.2 19 6.4 0.4 2 20 1196 1214 1195 1216 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.007	0.67	11.0	0.0	1	20	225	244	225	246	0.90
2	9	0.0003	0.029	15.3	0.8	1	23	305	327	305	327	0.98
3	9	0.054	5.1	8.2	1.0	2	21	380	399	380	400	0.92
4	9	0.052	5	8.2	2.9	2	21	794	813	793	814	0.93
5	9	0.0096	0.92	10.5	0.0	3	21	862	880	860	881	0.91
6	9	0.007	0.66	11.0	0.0	2	23	949	970	948	970	0.98
7	9	0.0041	0.39	11.7	1.3	1	23	976	998	976	998	0.99
8	9	0.00074	0.07	14.0	0.8	1	23	1060	1083	1060	1083	0.96
9	9	0.2	19	6.4	0.4	2	20	1196	1214	1195	1216	0.91

Sequence Information

Coding Sequence: ATGAGCTTCGCCTCTGggttcggattcggattctgTCTCTGGTTTGCTGTCTATTCCAAAGATTTAACCGCCCAGGAGCTGGGCGaagagaagcagcagctgcagcagcagcagcaggaggaagATCCAATGAATCCAATGGATCTTCAggataacaacaacaacagcgatgccgatgccgatgcagatgcagatgcagaggATGCTGTCTCCGTAGAGCCAGAAGATACTCAGGATCTAGGGGAAACCGAAATGGACCACCACCATCGGGAGCAGgatgagcaggagcaggaggaggcagGAGAGGCACCAATCAGTCCTAGCACGCCGCCACGGAGTCCTACGCCTCCTGCCAATCTGGTGCCAAAGCTGGAGCAGCCAGCGACTCCTCCCTCGGAATCGCCATCGCCCAGTCCttcgcccacgcccacgcccacacccacacccaccgcTACGCCCACGCCGAGGCTACCAAAGCTCCGGCTCAACGCACTGCTCGCCTCGGATCCCGCCCTCAAGCCGGACGCCAAGGAGCTGCATCTGTCGGACAAGCGTCTGCTGGCACCGCCGCCGCCCATCAAGCCCgagccgcagtcgcagtcgcagccacagccacagccacagcctccCCTCCAGCCCGATCTCGTGGAGCCGCTGCTGAAGCCGGCGCGATTCATGTGCCTGCCATGCGGCATAGCCTTCAGCTCACCCTCGACACTGGAGGCCCATCAGGCGTACTATTGCTCGCATCGCAACAAGGACACGGACGATGCGGATGGCTCGAGTGCGGACAAGTCCGGCGGTGGCGAGAAGTCCGCCGCGGGAGGAGCCTCtggcggaggcggcggcggcggcgggagtggcagcagtggctcGGAGCCGCCGGCAAAGGTGGCACGCATCGGGAAGCAGTACGCGTGCACCCAGTGCTCGTACAGTGCCGACAAGAAGGTGTCCCTCAACAGGCACATGCGCATGCACCAGACCTCGCCGGCCCCCAGTCTGGCGAGCCTGGGATCCCTCGGCAGTCTGCCCAGCCTCACGGCGAATGGAGTGCCGGGATCCGCAGGAGTGGGAGTAGGAGTGGGCAACAGCAGTGTCCTCGAGGAGGGCTCTAGTCAACAGCAAACCGACCGCTACTGCAGCGACTGTGATATCCGATTCAACAACATCAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGTTCCCGTCGCTCCGACGGCCGCGTGACCCCCAAGGGGGCAGCCGAGGCAGCTGCAGCCGCCGCTCGAGAATCAGGAGGATCGGTGTCGGCAGGCAGTGCTtcagcggcagcagccgcTGCTCCCGGAAAGCTCAGTCCACAGTCCACGCGCAACAAGACACCCACCCCGGCCATggtggcggcagcggcggcggctgcagcagcagcagcggcagctgccGCCTCGTTGCAGGCCCCCACCCCGCAGCCCTTTTTGGCCCTGCCCACGCATCCGATCATCATAGTGCCCTGCAGCCTGATCCGAGCGGCAAGCATCATTCCAGGACCACTGCCCACAACCACCACTTCGGGGATCGTCAATCTGGAGTCCACCTGCTTCACCGTGGACAATGGAGCCATCAAGCCGCTGGCCACAGCTCTGATCAGCAATGCACTCGCCGGGAATATGAATCACTTTGTCAATTCCCTGCACATACCCGCCCTGGAACCGGATCGTCCCACAGCTGGCACAGGAGCGGCCGAAGGAGGCGGCGTCCTGGAGCCAAAGAGCAGCAGTCCACCAGAACCCAAGAGAAAGGAGGCAGGAGCCAGTCGTGAATCTGCGCCCCTCGATCTTTCGTTTCGACGATCTCCCATCTCCATCATGCACCATCGCCAGCGGCATATCCGatccgctgccgctgccgcagctgcagccgctgcTCTGCTGGATGTGGAGGAAGTGCTCCTCGGAGCGGGCAAGGAAAACGTGGAAACTGTCAGCGGACGGGCTGGAGGCAGTGTGACGCCCGAGCAGATCGTCTGCGCACCCTCCCTGCCCAGCAGCCCTTCGATGAGTCCCTCGCCCAAGCGACGGGCGAGTCCTAGGAGTTCGGGGGCGGGCAGTGCCTCCTCCATGTCGCCGCCTGGCTTGAATCCCCATCTGCTGGACATCCGCTCGATGCTGCCAGCGGACTTTGGCCTGTCGGAGTCGCTGCTGGCCAAGACCAATCCGGAACTGGCCCTCAAGCTggcggctgccgctgcagctgctgttgcggcAGGAGGTGGCAGTGCCTCCTCTTCCGTGGCGGCTGCTCAGGCTGCCTCCAATCCAGGTGCCAATTctggcagccagcagcaacagcagcagcagcagcagccgcagatcTACGTGAAGCAGGGCGTCTCCAAGTGCAAGGAGTGCAACATCGTGTTCTGCAAATACGAGAACTATCTGGCCCACAAGCAGCACTACTGCTCGGCCCGCAACCAGGAGGCGACCGGCGAGGGCTCCGATGCCAAGTCCGCCGTCTCGCCATCGAATGCCACGGCCGGAAATGGTGGTGGTGCCTCTGCCGTGGAGACCACGCCCGTGGCCTATCAGCAGCTCATCTGTGCCGCCTGCGGCATCAAGTACACCTCGCTGGACAACCTGCGCGCCCACCAGAACTACTACTGTCCCAAGGGTGGGGCCGCGGCCGTCACTGCGCCCGCCGAGGCGACGCTGGTGGCCAAGGAGAAGTGCGGCAAATGCAAGACCCTGCACGATCACGGACACCCCTGTCCGGCGCCACCCGCCGCCACGCCTCTGACGGCGCCCGCCAGCCTTCAGTCGTCGGCGGGGGGAGCCTCCTCCGGCGTGAACAGCGTCAACAAGTGCCCCGTGTGTGGGGTCGTGAGTCCGACGGCGGCCCTGGCCCGCAAGCACATGGAGATGCACGGAACGGTGAAGGCCTTCCGCTGCAGCATCTGCCAGTACAAGGGGAACACGCTGCGCGGCATGCGCACCCACATCCGCACGCACTTTGACAAGAAGACGAGCGACGTCAACGAGGAGCACTACATGACCTGCATCTTCGAGGAGGATAGCTCTGCCCACTCCGCTGTGGTCCAGGAGATGCCGCCCACAatagcagcagcggcagcggcagcagcagcagcagcggcagtacCGCAGGAGCCACCGATGGAGCATCCGCCGCAGCTGTTCAACTGCGATTACTGCAACTACGCCTCCACCTACAAGGGCAATGTGCTCCGACACATGAAACTACTGCATCCGCATGTGGCCATCAATTCGCCCTCGATTTCCCCCGAGTCGCGTGAACAGGAGACGCTTCTTCCGAACTCCACTCCCAATCCGCACGAAGCGTCCAATGGCGAGGCAGTGAGCTTCCACATCAAATCAGAGCCTGGACTGGACAACCCGTCGACGCTGGGACTCGTTCACGAGAACAACAATTCGCCCATTGGCACGCCATTGCCGCACATCAAGGCCGAGCCGATGGACATGGGCATCGATGCCATGTCGCCCACATCGctggccctgcccctgcccctgccaccgcCCGTCGCCTCTCCCTTggcagccgccgcagccgaGGCCATGAAGAAATACTGCTCCGTGTGCGACATATCCTTCAACTACGTGAAGACCTTTCTGGCCCACAAGCAGTTCTACTGCAAGAGCAAGCCCCCACGACCCGAGGTCAACGACAGTCCCAGCCCCAATGCCAATCACCTGGCCGCAgtgggtgtgggagtgggagtggggatGGGCATGGGAATGGGAGGCCAGCCGCTGCAGTCGCCCAGCGAATTGATGCTCATGCAGAAGAACAAGGAGAACCTGCAGGAGGCGGCCATTTGA
Protein Sequence: MSFASGFGFGFCLWFAVYSKDLTAQELGEEKQQLQQQQQEEDPMNPMDLQDNNNNSDADADADADAEDAVSVEPEDTQDLGETEMDHHHREQDEQEQEEAGEAPISPSTPPRSPTPPANLVPKLEQPATPPSESPSPSPSPTPTPTPTPTATPTPRLPKLRLNALLASDPALKPDAKELHLSDKRLLAPPPPIKPEPQSQSQPQPQPQPPLQPDLVEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDTDDADGSSADKSGGGEKSAAGGASGGGGGGGGSGSSGSEPPAKVARIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAPSLASLGSLGSLPSLTANGVPGSAGVGVGVGNSSVLEEGSSQQQTDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGRVTPKGAAEAAAAAARESGGSVSAGSASAAAAAAPGKLSPQSTRNKTPTPAMVAAAAAAAAAAAAAAASLQAPTPQPFLALPTHPIIIVPCSLIRAASIIPGPLPTTTTSGIVNLESTCFTVDNGAIKPLATALISNALAGNMNHFVNSLHIPALEPDRPTAGTGAAEGGGVLEPKSSSPPEPKRKEAGASRESAPLDLSFRRSPISIMHHRQRHIRSAAAAAAAAAALLDVEEVLLGAGKENVETVSGRAGGSVTPEQIVCAPSLPSSPSMSPSPKRRASPRSSGAGSASSMSPPGLNPHLLDIRSMLPADFGLSESLLAKTNPELALKLAAAAAAAVAAGGGSASSSVAAAQAASNPGANSGSQQQQQQQQQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQEATGEGSDAKSAVSPSNATAGNGGGASAVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAAAVTAPAEATLVAKEKCGKCKTLHDHGHPCPAPPAATPLTAPASLQSSAGGASSGVNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDSSAHSAVVQEMPPTIAAAAAAAAAAAAVPQEPPMEHPPQLFNCDYCNYASTYKGNVLRHMKLLHPHVAINSPSISPESREQETLLPNSTPNPHEASNGEAVSFHIKSEPGLDNPSTLGLVHENNNSPIGTPLPHIKAEPMDMGIDAMSPTSLALPLPLPPPVASPLAAAAAEAMKKYCSVCDISFNYVKTFLAHKQFYCKSKPPRPEVNDSPSPNANHLAAVGVGVGVGMGMGMGGQPLQSPSELMLMQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00484660;
90% Identity: iTF_00474059;
80% Identity: -