Dhel002688.1
Basic Information
- Insect
- Drosophila helvetica
- Gene Symbol
- -
- Assembly
- GCA_963969585.1
- Location
- OZ018401.1:16806603-16807913[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 3.1 2.9e+02 2.6 3.0 3 23 40 61 38 61 0.87 2 9 0.00042 0.04 14.8 6.3 2 23 176 198 175 198 0.95 3 9 0.00041 0.039 14.8 0.2 1 23 204 227 204 227 0.98 4 9 7e-05 0.0067 17.3 1.0 1 23 230 252 230 252 0.97 5 9 1.8e-06 0.00017 22.3 4.2 1 23 258 282 258 282 0.98 6 9 6.4e-05 0.0061 17.4 0.3 1 23 288 310 288 310 0.98 7 9 5.2e-06 0.0005 20.8 1.9 1 20 316 335 316 338 0.93 8 9 0.00022 0.021 15.7 4.6 1 23 344 366 344 366 0.96 9 9 1.3e-05 0.0013 19.5 0.0 1 23 372 394 372 394 0.98
Sequence Information
- Coding Sequence
- ATGCTAAAACACTGCTTAATCCATGTGGACTATACGCGTCTGCATGCCCAGCAGAAAATGCAACCAAAATGCGGAGAGATCTTCTACGAGCAGGAGTGCAACCGCTTCCACTTGGCTTGCTGCCTGTGCGATATGAAGCACTTCTCCTTCGATGATTTCGTGCGGCACATTCGCAATGTACACTTCGACAAGCAGGGAAAGCCGCAGACGCATGCGGTTACCGTGCGTGCTTCGGCTCAGCGCCTGCCTGACACTGCGGAGGAGAAGCTCCTCTTCCCAGGGGAATATGATGATGTACAGACGGCAGGAGTCCCTATCACATTGCGAATCAGTGACCATGAAGACGTCCAGACGGAGGGCAATCGGGAAACTAAAGGGCTCTGGGAGTGTGAAGAGAATTCGCCAAAATCTGAGAGTGACGGCTGCGACCTGGACCCAGAAACCATCTTAAGCAGCCCCTGTGGTAGGACAGATGAAGAGGGCGAGGACCAGCAAAGTATTTTCAAGCGCCTGCCAAAAGAATTATGCTGTAAGCACTGTGATCGCAAATACACATCGCTGAAATACCTGAACACCCACATAAAGATGAGCCATCCGCACCCAAAGGCGTTCAAGTGCAGCGACTGTGGAGACACCTTCGATGTGGTACGGGCCCTGGAGGCTCATCGGCGCAAGCTGCACACTGATTTCAGCTGTAAACTGTGCGCCAAGATCTTCAAGAACTCACGCACCCTCCTCCGTCATGTGCAGGGACATTCTGGTGTGCGGCAGTACAAGTGCGACTTTGAGAATTGTGAGAAATCCTTTACGAACAAGCACAACCTCAACTCGCACCGCCGCATCCATAAAACGGAGCGCAACTACGTGTGCGAGTTGTGCGGCTATAGGTCGCGATACCGCGAGGCGCTCATCGTCCATCGACGCTCCCACACGGGCGAGAAGCCCTTCAAGTGTGAGACCTGCGGCCGCTGCTTCGCCTCGAAGTCGCTGCTGAACGAGCATCAGCCGATGCACTCCACGGAACGGCCCTACAAGTGCAAAGATTGCGAGGCAACCTTCTCCCGACCCAAGGCTCTCTACCACCACAAACATCTGCACCTGGCAATCAAAAAGTACAAGTGCAAGGTGTGTGGCAATGCTTACGCCCAGGCGGCGGGGCTCTCGGCCCACATGCGGGGACacaagcagcaggcagccaACGGTGTGTCGGACGGAAACGAAATGGAGATGTTATTTACTTGCTAG
- Protein Sequence
- MLKHCLIHVDYTRLHAQQKMQPKCGEIFYEQECNRFHLACCLCDMKHFSFDDFVRHIRNVHFDKQGKPQTHAVTVRASAQRLPDTAEEKLLFPGEYDDVQTAGVPITLRISDHEDVQTEGNRETKGLWECEENSPKSESDGCDLDPETILSSPCGRTDEEGEDQQSIFKRLPKELCCKHCDRKYTSLKYLNTHIKMSHPHPKAFKCSDCGDTFDVVRALEAHRRKLHTDFSCKLCAKIFKNSRTLLRHVQGHSGVRQYKCDFENCEKSFTNKHNLNSHRRIHKTERNYVCELCGYRSRYREALIVHRRSHTGEKPFKCETCGRCFASKSLLNEHQPMHSTERPYKCKDCEATFSRPKALYHHKHLHLAIKKYKCKVCGNAYAQAAGLSAHMRGHKQQAANGVSDGNEMEMLFTC
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00575026;
- 90% Identity
- iTF_00473972;
- 80% Identity
- -