Dhel016922.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila helvetica
Gene Symbol
topi
Assembly
GCA_963969585.1
Location
OZ018403.1:39400262-39402947[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.59 56 4.9 2.5 1 21 146 165 146 166 0.92
2 12 9.6e-06 0.00091 20.0 0.6 2 23 246 267 246 267 0.97
3 12 0.00036 0.035 15.0 0.1 2 23 294 315 293 315 0.97
4 12 0.076 7.3 7.7 0.0 2 23 382 403 381 403 0.90
5 12 1.4 1.3e+02 3.7 0.1 1 20 409 428 409 430 0.80
6 12 0.00069 0.066 14.1 0.4 1 21 450 470 450 474 0.90
7 12 0.012 1.2 10.2 0.7 2 23 489 511 488 511 0.90
8 12 9e-07 8.6e-05 23.2 1.9 1 23 536 558 536 558 0.95
9 12 0.0021 0.2 12.6 1.0 1 23 564 589 564 589 0.94
10 12 0.44 42 5.3 1.7 1 23 595 617 595 617 0.88
11 12 3.8e-08 3.7e-06 27.5 0.4 1 23 623 645 623 645 0.99
12 12 0.0017 0.16 12.9 2.0 1 23 651 674 651 674 0.96

Sequence Information

Coding Sequence
ATGGCTGACGAGAATTTTAGGAGCTGTGAGCTCGACGAGATGGAGCCCGTCGAGTATACCCTGGCGGAGATCGAATTTGACGACGAGACGCAGGTGAATTTCACCCACTTGCCGGATGCCACAGTGGTCGCATCCAGCGAGGAGAACAACCAAGAGCAGCGATCTCTCGGCCAGGAGGAACTGGTCCAGTTCTTTGCCAGCGCCCCACCACCCATCGTCCAGATGTCCACTGAGGTGGTGCTTCAGCGCACTCTGGAGCATCCAGCGCTAAAGCAAATACTCCAGGAAGCCGACGGCCAGCCAGATTTTGATCCGGCAGCAGAGCAAATGAAAATACGCGAATTCTTGGCTGGCGTCACCAACAATAAGATGACCACAGAGGAGTCGGTCTTTCAAGCACAACGCATGAGCACGGCATCGAATGGATCCCGCATCTACAAGTGCCGCCACTGCGGTGGCAAGTTCGACGCTGTGTACTTTTCCAGTCACATTTGCTCGTGCGAAGACGTCGCAAAGCCCGTCTATGATTCGCTTGGACATCAGGATAAGCCGCGATCAGTGAAGATGTTTACGGAAACGGGAACGGTCTCGGTGCCACGTATTGTTCGTGGAAGCGAGCGTGTCATCCTGGAAAATCAAGTACGGCTACGCCGCTACATGAAGGACGAACTGAAGTACGATGTCACCACGGGCGTGGACAGTTCAATGGCCAGGAAGTCCGGCAAGCAGCTCAATGAGTGCAGCATATGCGATCGGCAGTTCGTGCATGCCTCCGGCCTGGTGCGCCACATGGAGAAGCATGCCCTAAACCTGATCGCCCCACAGGCCAATGCGCTATCAAACCCGGCTCCGCCTGCCCCCGGCCTGGCTGTGGTGATAAAATGCAATGAGTGTGGCCGCATCTTCTACGACAGCAAGCTGGCCATGGACCATGTCCGCGTCCATTATCCCGAACAACCAAAGTCGAGCGAACCACCGACGGGCGAGAACGAAACCGAAAAGAAAGATTTCAGTAAGAGTATGAAGAAGGGGGAATGGCTCTTCTTGTGTGTGCAGTCAAAGAAACGGAGCGTCGATCAGAAGCAGGAGAAGCGAGCGTTGGAGGCCGGGCTATTTAGCACACTTATCCTGGGTAGCGTGCTGCAGTGCGAGTTCTGCGAGTACGTATTTGCGGATATTGAGAAGCTGCTCGTCCACTCGGCCGCGCACGTGGTGGAGAGGCGCTTCGAGTGCACCGTCTGCGGCATTACGATGAACACGGCCAAGGAGGCCAGTGTCCATTTCCAGACGGAATGTATCTTTATGCGCGAGGAACTCAAGCGGCTGGATGTCTCTCTGTTTCGATACTTTGTGTGCAATGTGTGCGAGCAGAAGTTCTCCACCGCAGACCTGCTGCTGGAGCACCGATACATCTACTACCATTACTTTCCACGCCTCACCGCCGACGGGAGtcccctgctgctgccctgcGAGTACTGCGATGCCAACTTCACTCATGCCCACGAGGTGGAGGCGCACAACCAGGAGAAGCATATGAACAAGAAGAGGCGAGAAAAGGAGACGCGCACCAACGGGCCCAGCTACGACAACGGCCGCCTTCGCCAGTACCTGTGCGACGTCTGTGGAAAGTCGTACACCCAGTCCAGCCATCTGTGGCAGCATTTGCGCTTCCACCAGGGTGTCAAGCCCTTTGCCTGCCAAGAGGCCAATTGCGATAGGAAGTTCACCATCCGTCCGGACCTCAACGACCACATCCGCAAGTGCCACACTGGAGAGCGACCGTATCATTGCCTGGTGTGTGGAAAGCGCTTCCTCACCGGCTCTGTTTTTTATCAGCACCGTCTGATACATCGCGGAGAGCGGCGCTACGAGTGTGATGAATGCGGCAAGCGGTTCTACCGAGCCGATGCCCTGAAGAATCACCAGAGGATTCATACTGGCGAGAAACCATATAGCTGCCTCTTCTGCACCAAGACATTCCGGCAGCGCGGAGACCGGGACAAGCATATACGTGCACGACATTCCCATTTGGACGCCAACTCTCGTCTTATGATGCAGATGCAGAAGTTTCAGCTGGAGTCGGCGCAAGCAGCAAAGGCCAGAGTCCGGCAGGAGCAAATGGGCGACGGTGACGGCTACTCGGCGGAAGCATCAGGATCTCAGGTCGGTCCTGAGGAAGATGGTCAAAACAACTCCGTTTCGGAAGAACAGGACGGAATGTTTTGCGATCCCATAAATGGATTCACTCTAAGCCAATTTGAGATTCAGCAGTATGTGGAGGAGGCTGAGCCCACACCCATGAATGAAGACGAAGATCATGAAATTATTGTGTACGAAAACCCAGAACCGACGGAGACAATGCCTTATGAACCACCACCAGAACCACAGCAAATAAAACGGGAGATTCCAGTGAAACCTGAAAGATCAAAGCGTAAGATTGTGGTGGTTAAGAATAATCCATCTCTACCGCTTTATCCGAATTCGTACATGTAA
Protein Sequence
MADENFRSCELDEMEPVEYTLAEIEFDDETQVNFTHLPDATVVASSEENNQEQRSLGQEELVQFFASAPPPIVQMSTEVVLQRTLEHPALKQILQEADGQPDFDPAAEQMKIREFLAGVTNNKMTTEESVFQAQRMSTASNGSRIYKCRHCGGKFDAVYFSSHICSCEDVAKPVYDSLGHQDKPRSVKMFTETGTVSVPRIVRGSERVILENQVRLRRYMKDELKYDVTTGVDSSMARKSGKQLNECSICDRQFVHASGLVRHMEKHALNLIAPQANALSNPAPPAPGLAVVIKCNECGRIFYDSKLAMDHVRVHYPEQPKSSEPPTGENETEKKDFSKSMKKGEWLFLCVQSKKRSVDQKQEKRALEAGLFSTLILGSVLQCEFCEYVFADIEKLLVHSAAHVVERRFECTVCGITMNTAKEASVHFQTECIFMREELKRLDVSLFRYFVCNVCEQKFSTADLLLEHRYIYYHYFPRLTADGSPLLLPCEYCDANFTHAHEVEAHNQEKHMNKKRREKETRTNGPSYDNGRLRQYLCDVCGKSYTQSSHLWQHLRFHQGVKPFACQEANCDRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAQAAKARVRQEQMGDGDGYSAEASGSQVGPEEDGQNNSVSEEQDGMFCDPINGFTLSQFEIQQYVEEAEPTPMNEDEDHEIIVYENPEPTETMPYEPPPEPQQIKREIPVKPERSKRKIVVVKNNPSLPLYPNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00611511;
90% Identity
-
80% Identity
-