Dhel003289.1
Basic Information
- Insect
- Drosophila helvetica
- Gene Symbol
- NFYC
- Assembly
- GCA_963969585.1
- Location
- OZ018401.1:22315385-22317547[+]
Transcription Factor Domain
- TF Family
- NF-YC
- Domain
- NF-YC domain
- PFAM
- AnimalTFDB
- TF Group
- Other Alpha-Helix Group
- Description
- Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 1 2.5e+04 -22.5 37.7 165 227 45 111 16 133 0.53 2 5 5.6e-48 1.4e-43 149.8 18.5 18 234 158 379 142 383 0.71 3 5 1 2.5e+04 -7.9 57.3 141 254 382 514 377 517 0.75 4 5 1 2.5e+04 -28.2 49.2 156 231 517 591 513 597 0.54 5 5 0.025 6.2e+02 0.1 12.4 134 175 599 640 594 645 0.85
Sequence Information
- Coding Sequence
- ATGTACGCCACCAACAATGGCGGCACAAATAAGGCGCCAAGCAGCAGCAATACCGCCACCACGCTGTTCGACAACACAATCACCGTGACACCGATCAAGGTGGATCTAAGCGGGCCCATGGCGCAGGCCTACGCAGCGGGCAAGGTAACGACGGGTGTTCAGCGACGAACGCCCAACGCTGTGGTTGTCACATCCCAACAGCAGCTACCCCAGCAGCTTccccaacaacagcagcagcagcagcagcaacaacaacaacaacagcaacaacaacaacagcagcagcagcagctccaacaaTCTGGCACGGCCACACTGACGATGCCCATGCAGGCAACGCTGGTGTCTAGCGCCTGCACCATTGTGAATCCCGGAATGACGATGACGGTCAatgccagtcccagtcccagcacGCCCAAGGAGAAGGCCACAAAGGCGACACGGGCGCAAGTGGCCCGGAAGCCGCCGCCGACCATCGAAAACTTCTGGCCGAATATCGTGAGTGAGGTGCATGGGATCGGACAGGTCGATGCCAAGCATCAGGTTCTGCCTTTGGCGCGCATCAAGAAGATCATGAAGCTGGACGAGAACGCCAAAATGATAGCGGGCGAGGCACCGCTGCTCTTTGCCAAGGCCTGTGAGTACTTCATCCAGGAGCTGACCATGCACGCCTGGGTGCACACCGAGGAGAGCCGCCGGCGCACGCTGCAGCGGTCGGACATCGCCCAGGCCATAGCCAACTACGATCAGTTCGATTTCCTCATCGACATAGTGCCACGGGAGGAGATCAAGCCATCGTCGGCGCAGAAGGGCAAAGATTCAATGGGAGCGTGCTCAACCACGGGTATGGCCGGTTCCGTTGCCGGCAGTTCCGTCGGCCACAGCTCCTCCACCGCCACCACAGCCACCGCCACGAGCAACTTCAGCTTGGGCGGCACCACTGTACCTTCTGCCACGGCCACCCTAAAAATGGACACCAGCAGCGCTGCGGCCGCAGCCGAGGTACTCGGCTTCAGCACCGTCAATCAGGACATTTTCACCGCccaactgcagcagcatcaacaccagcagcagcagcagcagcagcatcaacccCAGCATGTGCAGATCATCCAGCAGGCCGGAGGCCATGCGGGcgggcagcagctgcagtACTTCATTGCGCTGCCGGGGCAACAGGGGACGCAGCTGGTCCAGCAAGTGCAgcaggtgcagcagcagccagcccaGAATCACTTGTCCCAGAGTCTTGGCCTCAATATTGTGGCTGCCCAGCAGCCCACACAGCAGCTGATCCTCACCACCGGCCCCAATGGGCAGCTGACCGCCACTCCGGCACCCACAACGGCAGCCCAGCAGCAAACAGCCCTGCTCCAGAATCTCGCCCAgcagcatcaccagcagcaacagcagcagcagcagcaacaacaacagcagcaacagcaaatcCAGATAATTCAGCAAGTGGTGGGCCCCACGGGAGAGATAACCAATGTACCAATTGCCATCACTGCGAGCCACTTGCAGCTGCTGCGACTGCAgatgcagcaacagcaacaacagcagcagcagcaacaacaacagcagcaacaacaggtgATCATACCCACACAGCTGCTGACGGCACAGCAGCTCATCCAGCTGGGGGCCACGCCCGCGGGCACAGCcacccaccagcagcagcagcatcatcaccagcagcagcagcagcatcaccaccagcagcagcagcagcatcagatTCAGGTGCAGgtacagcaacagcagcatgtAAATCTCAGCCAGAGCAACTCCAGCACCGTCACCAATGCCACGCCCATTTACATTAACTCGACGGTATCGAGTGCGCAGACGGCAACGCAatcgcaacagcagcagcagcagcaaacgcAGGCGCAGACGATCACCACAATGTCCACGGATCGGACGCTGAGTGGAGGGTTTCGGTAA
- Protein Sequence
- MYATNNGGTNKAPSSSNTATTLFDNTITVTPIKVDLSGPMAQAYAAGKVTTGVQRRTPNAVVVTSQQQLPQQLPQQQQQQQQQQQQQQQQQQQQQQQLQQSGTATLTMPMQATLVSSACTIVNPGMTMTVNASPSPSTPKEKATKATRAQVARKPPPTIENFWPNIVSEVHGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMHAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSSAQKGKDSMGACSTTGMAGSVAGSSVGHSSSTATTATATSNFSLGGTTVPSATATLKMDTSSAAAAAEVLGFSTVNQDIFTAQLQQHQHQQQQQQQHQPQHVQIIQQAGGHAGGQQLQYFIALPGQQGTQLVQQVQQVQQQPAQNHLSQSLGLNIVAAQQPTQQLILTTGPNGQLTATPAPTTAAQQQTALLQNLAQQHHQQQQQQQQQQQQQQQQIQIIQQVVGPTGEITNVPIAITASHLQLLRLQMQQQQQQQQQQQQQQQQQVIIPTQLLTAQQLIQLGATPAGTATHQQQQHHHQQQQQHHHQQQQQHQIQVQVQQQQHVNLSQSNSSTVTNATPIYINSTVSSAQTATQSQQQQQQQTQAQTITTMSTDRTLSGGFR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00580709;
- 90% Identity
- iTF_00574794;
- 80% Identity
- -