Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 9.5e-06 0.00063 20.0 1.9 3 23 155 175 154 175 0.97

2 6 2.3e-06 0.00015 21.9 1.0 1 23 181 204 181 204 0.98

3 6 1.2e-05 0.00081 19.7 3.2 1 23 210 233 210 233 0.98

4 6 0.00053 0.035 14.5 1.1 2 21 240 259 239 261 0.94

5 6 0.0042 0.28 11.7 1.6 1 23 267 289 267 289 0.96

6 6 0.0002 0.014 15.8 0.6 1 23 295 319 295 319 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	9.5e-06	0.00063	20.0	1.9	3	23	155	175	154	175	0.97
2	6	2.3e-06	0.00015	21.9	1.0	1	23	181	204	181	204	0.98
3	6	1.2e-05	0.00081	19.7	3.2	1	23	210	233	210	233	0.98
4	6	0.00053	0.035	14.5	1.1	2	21	240	259	239	261	0.94
5	6	0.0042	0.28	11.7	1.6	1	23	267	289	267	289	0.96
6	6	0.0002	0.014	15.8	0.6	1	23	295	319	295	319	0.91

Coding Sequence: ATGAGCCTAGCgcaaggcaaggcaaataCCAGAGAGCATTGCTACCTGTGCAACTGCAGCGATGACGATGTTACAGTATTCGGGAATATGTTCGAGAAACGATTTACCCCCACTGGCAAAGAACTCAATTCAATGGGTTCAATTTTAAGCCAGATTTTGGGCCACAAACTGCACGTTGAGCACTTGCATTCCACGTATTTATGCAGCGGCTGCAAGATGGACTTGCTTCAATATGAAACGTATCAGGCTAAACTCCTTGCGACATGCTCGAATATAAGAAATCGGCACACAGAAACCCTTAAATTGTACGAACCTAAAGAGGGAATAGAAGATGAATACTTCGATCATGACGATGATTTGATTGAGGAGGACTCCGATGGTGGTGACTACCAAAAGAAGAGTACGCTGGAGCAGCCATTAAAGACGAGCCCAGATGGCAagcagagcaaaagcaaaaactgctGCTCCTACTGCGGACAGAAGTTTGCCCGGCGTCAGTGGCTGGAGGAGCACCAGCGCATCCATACGGGCGAGCGGCCATTCAAGTGTGAACTGTGCAACGCCCGCTTTGCGCAGCGTTCCAATTGGCGCACCCACATGCTGACCACGCACCAAAACAAGGCCAACTTCAAGTGCAACCAATGCGACAGGCAGTTCAAGCGTCGGCGTCTGCTCGACAATCACATCAAGTCGAGGCACACAAAGTTGCGCGATTTACGCTGCACCCAATGCGATGCTACTTTCGGGAATCCGGTGTACTTACGACAACATATGCTGTGCCACACGGGCGAGAAGCGATTTAGCTGCCTGATCTGTGACAAGCGATTCGGTCGCATCGAGAATCGAAATATCCATCATTTTGTGCATAGCATACGGAAACCGTATGCCTGTCTCGTCTGCGGCAAAGAATTCATGCGGAAACAGCACATCCAGCAGCACATTGCGACCAGCATGCATCACAACCCGGATATTGTGCGCCGCGAGCCTCTGTTCAACGTGGCCAACAGTAATAAGCTGCGGATGCATGCTcttgcagcagccaacaaataa
Protein Sequence: MSLAQGKANTREHCYLCNCSDDDVTVFGNMFEKRFTPTGKELNSMGSILSQILGHKLHVEHLHSTYLCSGCKMDLLQYETYQAKLLATCSNIRNRHTETLKLYEPKEGIEDEYFDHDDDLIEEDSDGGDYQKKSTLEQPLKTSPDGKQSKSKNCCSYCGQKFARRQWLEEHQRIHTGERPFKCELCNARFAQRSNWRTHMLTTHQNKANFKCNQCDRQFKRRRLLDNHIKSRHTKLRDLRCTQCDATFGNPVYLRQHMLCHTGEKRFSCLICDKRFGRIENRNIHHFVHSIRKPYACLVCGKEFMRKQHIQQHIATSMHHNPDIVRREPLFNVANSNKLRMHALAAANK

Sequence clustering based on sequence similarity using MMseqs2