Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 8.8e-05 0.0065 17.0 4.1 2 23 121 142 120 142 0.97

2 6 1.2e-06 8.7e-05 22.9 2.3 1 23 148 170 148 170 0.98

3 6 0.00043 0.032 14.9 3.8 2 23 177 198 176 198 0.96

4 6 0.00072 0.054 14.2 1.7 3 23 206 227 204 227 0.96

5 6 0.00056 0.041 14.5 0.9 1 23 251 274 251 274 0.95

6 6 2.4e-06 0.00017 22.0 2.0 1 23 280 302 280 302 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	8.8e-05	0.0065	17.0	4.1	2	23	121	142	120	142	0.97
2	6	1.2e-06	8.7e-05	22.9	2.3	1	23	148	170	148	170	0.98
3	6	0.00043	0.032	14.9	3.8	2	23	177	198	176	198	0.96
4	6	0.00072	0.054	14.2	1.7	3	23	206	227	204	227	0.96
5	6	0.00056	0.041	14.5	0.9	1	23	251	274	251	274	0.95
6	6	2.4e-06	0.00017	22.0	2.0	1	23	280	302	280	302	0.97

Coding Sequence: ATGGTAGAAGttgtaaacataaacataaaatgcgCCGAAATACACTGCAACACTTCAGTAGAAGCAAACTTTCTGATAAAATGTATTTGCGGTAGCTCTTTATTGGACTACGTCTCATTCCAGCGGCACTTTATTAGTGACCATTTGGAGCCAGAGCTCCACACCGAAAAGCAACGGATCTCTGTGGCACCTATTAACTGTTTAAATGAACCTGTTGTTGAGCTTCCATCGATGTCAGAGCTGCCAACGGTCATGGAATCTGCATATGATGTCCTTACGGTCGACGACTCCAAGTGGAACAACGAATCATCGCCGAAGCAACCCAAATGCCGTCCTTATAAACGACGCTGTGTACCCAATACGTGCGCATATTGTGGGCGGACATTTCGACGCCGCCATTTGCTGGACACCCATCTGCATATCCACACTGGCAGCAAACCCCATCAGTGCGACATGTGTGGAAAGCAGTTCCGAGCCATATCCACACTGACGCGCCACCTGCGCACGCATGAAGAACGTAAGGTGCTCCAGTGCCAGCACTGCGAGAAGCTATTTACGCATCGCAGTGCGCTGCTCAGCCACGAGCTGCGGCACACCCAAGTGCGCCGTTGGGCCTGCACCAGCTGCGACAAGAGCTTCTACACCCGCAACCAAATGGACACCCATAAGCGGAAGATGCATGCGACTGTCAGCACACAGAAAGGCCTGGATCAGGCAGACAACGCTGACCTAAGCCCATCCGTACTGCCGTTTGCCTGTGAGCTATGTGGCAACCGTTATCGTAGTGCCTCCACGCTGAGCACCCACAAACTGAAGAAACACTATCGCCTGGCCAAATACAGCTGCGAGCAGTGCGACAAAAAGTTTGTTGACGCCAATCACTTGCAGCAGCACCAGTTTATTCATGTGAAGCCCCAagttacaataaataattaa
Protein Sequence: MVEVVNINIKCAEIHCNTSVEANFLIKCICGSSLLDYVSFQRHFISDHLEPELHTEKQRISVAPINCLNEPVVELPSMSELPTVMESAYDVLTVDDSKWNNESSPKQPKCRPYKRRCVPNTCAYCGRTFRRRHLLDTHLHIHTGSKPHQCDMCGKQFRAISTLTRHLRTHEERKVLQCQHCEKLFTHRSALLSHELRHTQVRRWACTSCDKSFYTRNQMDTHKRKMHATVSTQKGLDQADNADLSPSVLPFACELCGNRYRSASTLSTHKLKKHYRLAKYSCEQCDKKFVDANHLQQHQFIHVKPQVTINN

Sequence clustering based on sequence similarity using MMseqs2