Basic Information

Insect: Drosophila hamatofila
Gene Symbol: ZNF574
Assembly: GCA_035045345.1
Location: JAWNPA010000012.1:25461064-25463266[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.025 1.8 9.3 0.5 2 23 321 343 320 343 0.96

2 10 2 1.5e+02 3.3 0.2 6 23 353 370 353 370 0.97

3 10 2.8e-05 0.0021 18.6 0.8 1 23 376 398 376 398 0.98

4 10 0.0028 0.2 12.3 2.4 1 21 411 431 411 434 0.87

5 10 5.5e-05 0.0041 17.7 0.7 1 23 442 465 442 465 0.97

6 10 2.7e-05 0.002 18.7 1.0 3 23 473 494 471 494 0.92

7 10 0.0028 0.21 12.3 0.4 2 23 506 528 505 528 0.97

8 10 0.00085 0.063 13.9 7.0 1 23 535 558 535 558 0.93

9 10 2.5e-06 0.00018 21.9 1.2 1 23 564 586 564 586 0.98

10 10 5.9e-05 0.0044 17.6 1.4 1 23 592 615 592 615 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.025	1.8	9.3	0.5	2	23	321	343	320	343	0.96
2	10	2	1.5e+02	3.3	0.2	6	23	353	370	353	370	0.97
3	10	2.8e-05	0.0021	18.6	0.8	1	23	376	398	376	398	0.98
4	10	0.0028	0.2	12.3	2.4	1	21	411	431	411	434	0.87
5	10	5.5e-05	0.0041	17.7	0.7	1	23	442	465	442	465	0.97
6	10	2.7e-05	0.002	18.7	1.0	3	23	473	494	471	494	0.92
7	10	0.0028	0.21	12.3	0.4	2	23	506	528	505	528	0.97
8	10	0.00085	0.063	13.9	7.0	1	23	535	558	535	558	0.93
9	10	2.5e-06	0.00018	21.9	1.2	1	23	564	586	564	586	0.98
10	10	5.9e-05	0.0044	17.6	1.4	1	23	592	615	592	615	0.97

Sequence Information

Coding Sequence: ATGGCAGCGTGTGTGCTTTGTTTTCGCTGCTGTAACAATGCTGAATCCTATAAAATATTCTCCGAACTTGGTTTGCGGCTCAACATttgcaaaacaataaacaaacatttctgGCTTGAGTTGAGCAGCGCAACTGGTGAGCACGAGCAAATATGTCGCCAGTGCTGGGAGTGCGTGAGCAGCTTCAATGAATTCTATCAGCGCGTCTACAATGCCCATCAGGAGAGACGCAGCGACGTGAAGAATGTCCACATTGAGTTCTGCGACGAATCGGAGGCAGCGAATCCATTGGCATTTGGCGGTGAGCTGGATGCACTGGCTGAGGATTTCTTTGCCACGGGCGATGTCAAGGTGGAGGTGAACGAGCTTGAGCCGCTGCCCAAGCTGGAAGTGCTCGAAGAGCAGTTGCTGGAGCAGAAGAGTGCAGCTACAAAGAGACCGAGTGCTGAGCATCCAACAAGTGCTAAGCGACGCATTAAAAAAGAGCAGCCCACCATCGGCAGTGATTCGGATGGCGACATACCGTTATCTGAGTTTTTGGATCTGAAAACATCAGCGGCGAAGGCAGTCAAAGGGCAACCGTTGCGTCGGAGCACACGCCGTGGACAACGTTCAAAAACGCCGCCAGCATCCCCGTCCAACTGTATGAAGAACGAGCACGATTCGGACGAAGACAATGATAAAATGGAGTTTCTGGCTGCGGAGGCAGTGCTGGGTACTGAGGACAGCGCCAGCTCGAGCgaaagcagcgacagcgactcgGGCAACAGTTTGCCAGACATTGAGCCAGAGGAGCGCTATGCAGAGATACCCAAACGTGTTGTAGTCAAGCCGAAGAAGTATCGGAAACGTCCCAAGCCTCTGATTCCGCCTGTGAGAATGAGCCGCGAGGAGATTGAGAGGCGAAAAGCGCAACAAAAGGAATTCGATGAGATCATCTTTGATTTCTTCAAGAAGCTGCCATGTCATGTCTGCAATCTGCTGGTGCCCAATTTCGGGGACATGCGTCGCCATCAGCGTATGTCCCATAACATCGAGAGTGGCTTCATTGCCTGCTGTGGTCGCAAATTCCACATCCGTCGCGCATTAGCTGAGCATGTGTTAGTTCACAAGAATCCCGAGCACTTTATGTGCACGCAGTGCGGCCGCATATTCCAGGATTCCAAAAGTCTCGAGACGCACGAGCAAACGCATATGAATCCGCAAACGGATGCGAAGGATAAACGCATGTATCCATGTGATAAGTGTACCAAATGCTTCACCACAAAGGCCGCTGTGGAGTATCACAATGTGTCCAAGCATGTGCCCAAGTCGGATTTCAAATACACCTGCCCAGAGTGCAACAAGAAAGTGCCCACCGAACGCAAGCTCAAGGAGCATTTGCGCTATATGCATGATCCGGAAACTGCCATCATTTGCGACAAGTGCGGCAAGACGTTGCGCTCCCAGGCGAACCTTAAGAAACACCATGAACTGGAGCATTCCGATAAGCCACGGCCCAAGCCCGATCCCGTGCAATGCGAGATTTGTGGCACTTGGCTGCGCCACTTGTCAGGACTCAAGCAGCACATGAGCACGGTCCATGAGCCGCCTGGTGGCGAGCATCGATGCCACATCTGTGACAAGAAGTCCACAAATTCGCGGGCACTCAAACGCCATATATACCACAATCATCAGTGCGAGCGAAAGTTTCGATGCACCATGTGCGAGAAGGCGTTCAAGAGGCCACAGGATTTGAGAGAGCACACGTCGACGCACACAGGTGAGGTGCTGTACACGTGTCCGAACTGCCCGCAGACGTTCTTCTCGAATGCCAACATGTACAAGCATCGCCAGCGCTTGCATCGTGCCGAGTGGGAGGCGGATCGCAAGAAGCCGCTGCCACCGAACATAATGCAACAGGCAGTGGTCGCTACAACGGCCATGAAGAAGCGTCAGACCGCCGAGTCCACCACTGCTGCCACCCAGAAGCAGGAGacaaacaactgcaacaatagTAATAGTATTTAA
Protein Sequence: MAACVLCFRCCNNAESYKIFSELGLRLNICKTINKHFWLELSSATGEHEQICRQCWECVSSFNEFYQRVYNAHQERRSDVKNVHIEFCDESEAANPLAFGGELDALAEDFFATGDVKVEVNELEPLPKLEVLEEQLLEQKSAATKRPSAEHPTSAKRRIKKEQPTIGSDSDGDIPLSEFLDLKTSAAKAVKGQPLRRSTRRGQRSKTPPASPSNCMKNEHDSDEDNDKMEFLAAEAVLGTEDSASSSESSDSDSGNSLPDIEPEERYAEIPKRVVVKPKKYRKRPKPLIPPVRMSREEIERRKAQQKEFDEIIFDFFKKLPCHVCNLLVPNFGDMRRHQRMSHNIESGFIACCGRKFHIRRALAEHVLVHKNPEHFMCTQCGRIFQDSKSLETHEQTHMNPQTDAKDKRMYPCDKCTKCFTTKAAVEYHNVSKHVPKSDFKYTCPECNKKVPTERKLKEHLRYMHDPETAIICDKCGKTLRSQANLKKHHELEHSDKPRPKPDPVQCEICGTWLRHLSGLKQHMSTVHEPPGGEHRCHICDKKSTNSRALKRHIYHNHQCERKFRCTMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPQTFFSNANMYKHRQRLHRAEWEADRKKPLPPNIMQQAVVATTAMKKRQTAESTTAATQKQETNNCNNSNSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00508523;
90% Identity: iTF_00573516;
80% Identity: -