Basic Information

Gene Symbol
zfh1
Assembly
GCA_035045345.1
Location
JAWNPA010000020.1:11496006-11526413[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.02 1.5 9.6 2.4 2 23 73 95 72 95 0.93
2 9 0.0014 0.1 13.3 0.1 1 23 304 326 304 326 0.97
3 9 3.2e-05 0.0024 18.4 1.8 2 23 340 361 339 361 0.97
4 9 1.1e-05 0.00084 19.8 6.4 1 23 370 392 370 392 0.99
5 9 0.00033 0.025 15.2 1.2 3 21 400 418 398 419 0.94
6 9 0.03 2.2 9.1 0.4 2 21 648 667 647 668 0.92
7 9 1.5e-05 0.0011 19.5 0.5 1 23 998 1020 998 1020 0.94
8 9 5.5e-05 0.0041 17.7 7.4 1 23 1026 1048 1026 1048 0.98
9 9 0.0028 0.21 12.3 4.3 1 21 1054 1074 1054 1075 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTTTGGCGCCATCGTCTACACGTTTTGGCCAAGAGGATAACATTATACAGCAGAGCATGCCATCGTCCACAGCCTTCTCCATGCAGTTTTCCTCTTTGGCCTCCAGTTTGCATCACCACCAAGCCCACAACAAGCCCAGCAATGTGGCCGCCAACCCAGAGCTGGCCAACAGCGCCACAGCCAGCGCAGCCGAGGACTGTTCGGTCAAGTGCACGCAGTGCCACAAGCGCTTCACCGAGTTTCAGTCCTTCAGCGAGCACATTGCCAACGAGCATCCGCATGACAAACTCAACTACGAGTCACATCGTGCGGCAGCTGAGGCTGCGCAGCCGGAAAGCGAGGCGGAGGAGGACGAGCAGAGCaatttgagcagcagcagtcgtcgCTATGTCAAATCTccaaacaccaacaacaacaacattaataacaacaacaacaacaacaacagtgagaCAGCCAAGaatcaaaataacaacaacagcaacagcggcagtggcagccatAGAAGCCAGCACTCACCTCTCTGCTCACCTGTTGCGGCCACGCCCAACGATCTGTTTGCCCACCTGCCGCATACGCCGCCCCAGCTACCCGCCCATTTGCATGCCCAGTTCATGGCCGCCGCTGCTATGGCCATGCAATCCGCCCGATCCGCCAGCTCAcccagccaacagcagcaacagcagcagcagctacaactgcaacagcaacagcagcaacagcagcagcaacagcaacagttgcaacagtcgccgcagctgcagcaggctttgctgctgccaccaccCCAAcccggcagcaacagcagcgttGGCAGCAACTCTGCCTACGACCTGGACTTGAGTGCCCCACGCTCCACCTCCAGCCCGGGCTCCACAACGGGCGACCTGGGCGCCGCCTTTCCCTGCATGCAATGCACCGCCGCCTTCGCCAGCCGCGAGCAGCTCGAACAGCACCAGCTGCTCCACTCGCCCACGGGCCCACAAACCACTCAAAATGTGACACAGACCTGCAAAATATGCCACAAGGCCTTCGCGAACGTGTACCGCCTCCAGCGTCACATGATCAGCCACGATGAGTCCGCGCTGCTGCGCAAATTCAAGTGCAACCAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGTGGCAAGCGCTTCTCGCACTCGGGCAGTTTTTCCTCGCACATGACCTCCAAGAAGTGCATCAGCCTGGGCCTCAAGCTTAACAACAATCGCCAGATGCTCAAAACTCTCGACAAGAACTCAAGCGCTCGGCGCTCACCCACGGatcagcaccaacaacaacaacagcaacagcagctggcggGCAAGCGGAAGCTGGCACCAGAGCAGGTGCTGCCCAATCCCATGAACTACTTTGCCGGCGAAGTGCAGAACCCACCCACAGCTGTCAATGCGCCTGCGCCCTTCTATCCCAACTATATGAATGCGGCACTGCTGGCCTTCCCCAATGCCATCATGGCTGCGGCGCTGGATCCCCGCATGCATCCCTACAGCATCCAGCGACTGTTGCAGCTGACTGCTgccgggcagcagcagcagcagcagcgggaggAGCAGCTGGAACAGGAGCACAGAGAGGAACAGAAACTGTATGAGACCAGAAAGGATGATGATGAGACGCCGGATGAGCCCAAATTGGTGATGGATTTGGAGGAAGCAGAGCCCAAGCCTACGGCCAGCCCTGAAGTGGCCGTTGCCGAGCCGGCAGCTGTCGACGTTGGCGTCGTCAAGCAAGAGCCCAGTCGCGAACCAACGCCCCCGGACACGCCCAAGTCCATCAAGGTGGaacaggaggaggaggaactAGAGCCAGTGGCCGTGGAGCAGTCGCGGGCGTCGACACCTCAAGATCTGCGCTGCAGTCGCTGTGCCAAGCAATTCAATCATCCCACAGAGCTGGTGCAGCACGAGAAGGTGCTATGTGGCCTCATTAAAGACGAGCTGGAGCagcaataccaacaacaacaacaacaacagcaCGAAGCGGACGAGGATGAGGAAGACGAGGAGGAGCGACGCCAGGATTACCATGccggcagcagcgacagcggcgaACGCAAGGTGCGCGTGCGCACCGCCATCAAcgaggaacagcagcagcagctgaaacagCACTACGCCCACAATGCGCGTCCCAGCCGGGACGAGTTCCGCCTGATAGCCGCCCGCCTGCAGCTGGACGCGCGCGTCGTCCAGGTCTGGTTCCAGAACAATCGCTCGCGCGAACGCAAGCTGCAGAACTATGCGAGCAACGGCGAGGCCACAGCTGTCGCTCCACAGCCGCAAGCGCAGCCACGCGCTGGCGAGGATCAGCCGCTGGACTTGTCCGTCAAGCGGGACGCTTCGCCGTTGTACGGCTTGGCGTCGTCCCAGCAGGCAGCTGTGCTGCCCGCGCCCGCCGACTTCCAGGAGACAATGGCCATCAATCTGAGCCGCAAGCTCTCCGGCTCGGCGTCCATGTCGCCGGCTTCGTTGTCGCCCTGCTCGGGCGCCTCCTCGCTGCAGCAatcggcagcagctgctgctgccgctgcagcgcTCTACTTTGCGCCTCCCTCGccgcccagccacgcccatgaGCTGGCGTCCGGCGCAGCGCCGCGTGGCCAGGCCTTCGCCGGCCTGCCGCCCTACATGCTGCCGCGCCTGCCCATGGAGGCGCTCTTCCAGATGCGCCCTGGCGGCGACTATGCGCCCAATCCGCTCATGAACAGTATTAAGCTGCCCGACTACCGCGGCACCAGCCTCAGCCCCGGCGGCTCCGAGAAGCGTTCGTGGCGCGACGACGACTCGCGCATCTCGCACGACGATGAGTACGGTCTGGCGAGCGGCGGCCTGCTGCCGCCCAAGCCCAAGCGGGCCAAGGCCGAGACCCATGGGCATGCCGGTGACCCGGACCTGCCCTTCGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCGCGTCACAAGTACGAGCATTCCGGTCAACGACCCTATCAGTGCATGGACTGCCCCAAGGCCTTCAAGCACAAGCATCACTTGACGGAGCACAAGCGTCTGCATTCCGGCGAGAAGCCATTTCAGTGCTCTAAGTGCCTGAAGCGCTTCTCCCACTCGGGCAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence
MLSCLAPSSTRFGQEDNIIQQSMPSSTAFSMQFSSLASSLHHHQAHNKPSNVAANPELANSATASAAEDCSVKCTQCHKRFTEFQSFSEHIANEHPHDKLNYESHRAAAEAAQPESEAEEDEQSNLSSSSRRYVKSPNTNNNNINNNNNNNNSETAKNQNNNNSNSGSGSHRSQHSPLCSPVAATPNDLFAHLPHTPPQLPAHLHAQFMAAAAMAMQSARSASSPSQQQQQQQQLQLQQQQQQQQQQQQQLQQSPQLQQALLLPPPQPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLGAAFPCMQCTAAFASREQLEQHQLLHSPTGPQTTQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISLGLKLNNNRQMLKTLDKNSSARRSPTDQHQQQQQQQQLAGKRKLAPEQVLPNPMNYFAGEVQNPPTAVNAPAPFYPNYMNAALLAFPNAIMAAALDPRMHPYSIQRLLQLTAAGQQQQQQREEQLEQEHREEQKLYETRKDDDETPDEPKLVMDLEEAEPKPTASPEVAVAEPAAVDVGVVKQEPSREPTPPDTPKSIKVEQEEEELEPVAVEQSRASTPQDLRCSRCAKQFNHPTELVQHEKVLCGLIKDELEQQYQQQQQQQHEADEDEEDEEERRQDYHAGSSDSGERKVRVRTAINEEQQQQLKQHYAHNARPSRDEFRLIAARLQLDARVVQVWFQNNRSRERKLQNYASNGEATAVAPQPQAQPRAGEDQPLDLSVKRDASPLYGLASSQQAAVLPAPADFQETMAINLSRKLSGSASMSPASLSPCSGASSLQQSAAAAAAAAALYFAPPSPPSHAHELASGAAPRGQAFAGLPPYMLPRLPMEALFQMRPGGDYAPNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHDDEYGLASGGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00530857;
90% Identity
iTF_00559678;
80% Identity
iTF_00516155;