Dham012578.1
Basic Information
- Insect
- Drosophila hamatofila
- Gene Symbol
- Runx1
- Assembly
- GCA_035045345.1
- Location
- JAWNPA010000039.1:7287426-7290495[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 6.5 1.6e+04 -4.5 2.4 62 68 69 75 43 91 0.59 2 2 4.9e-50 1.2e-46 157.6 0.0 4 93 110 199 107 201 0.97
Sequence Information
- Coding Sequence
- ATGCACATTTCAGCCGAGGTCAGTTCGACCACCTCAAATCAAacacaccagcaacagcagcaacagcaacagcaacaacagcagcagcaacagcagcagccaacacaacaacagcaacatccaacggcagcaacaacaacaataacaacaaccggCAGCACAACGAAGCGTCGCAATGCAGAGtccaataataacaacaacaacaacaacagcagcaccgccaacaacaacaacaataccaaaagcaacagcaacaacaacagcaaagccgTGGATACAAGTCCGTACCTGACGCCCGAGAATCTGATCGAGCGCACTGTCGACGTCCTGCTAGCCGAACATCCTGGCGAGCTGGTCAAGACGGGCTCCCCACACGTAGTGTGCACCACATTGCCCACGCACTGGCGCTCCAATAAAACGCTGCCGATCGCCTTCAAGGTGCTGGCGCTGGGCGAGGTCATGGATGGCACCATTGTCACCATACGCGCCGGCAACGATGAGAACTTCTGCGGGGAGCTGCGCAACTGCACCGCCGTCATGAAGAACCAAGTGGCCAAGTTCAATGATCTGCGATTCGTTGGACGCAGCGGAAGGGCCCTTGGCCCTTGGCCCTTGGCCCACGGCCCATGGCCCATAGCCCTAAGCTCTCAGCCCTGGGCCACGGCCGAACCAAATTAA
- Protein Sequence
- MHISAEVSSTTSNQTHQQQQQQQQQQQQQQQQQPTQQQQHPTAATTTITTTGSTTKRRNAESNNNNNNNNSSTANNNNNTKSNSNNNSKAVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRALGPWPLAHGPWPIALSSQPWATAEPN
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00588642;
- 90% Identity
- iTF_00512495;
- 80% Identity
- -