Basic Information

Gene Symbol
ush
Assembly
GCA_900245975.1
Location
NW:6360974-6430183[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0057 0.34 11.0 0.0 1 20 216 235 216 237 0.90
2 9 0.00025 0.015 15.3 0.8 1 23 289 311 289 311 0.98
3 9 0.044 2.6 8.2 1.0 2 21 365 384 365 385 0.92
4 9 0.043 2.5 8.3 2.9 2 21 771 790 770 791 0.93
5 9 0.0079 0.47 10.6 0.0 3 21 839 857 837 858 0.91
6 9 0.0057 0.34 11.0 0.0 2 23 920 941 919 941 0.98
7 9 0.0033 0.2 11.8 1.3 1 23 947 969 947 969 0.99
8 9 0.00061 0.036 14.1 0.8 1 23 1024 1047 1024 1047 0.96
9 9 0.17 9.8 6.4 0.4 2 20 1154 1172 1153 1174 0.91

Sequence Information

Coding Sequence
ATGTCACGACGCAAACAATCAAACCCGAAGCCGTTGAATAAAGGTGATTGTTCCGATACCACAGAAGAGATGACCGTTGACAGCAGAGATTCCAAAGATTTAGCCGCTCAGGAAATGGGCgaagagaagcagcaacagcagcagcagcagcagcagcaggaggagcaagacGAACCCATGGATCTGCaggataacaacaacaacagcgatgGGGAGGCAGACACAGAGGACTCCCTCTCCGTAGCATTACCAGAAGAGACGCAGGCAGAGCTAGGGGCAACAGAAATGGAGGCCGAGGAGGCTACACCCCACAGCAGTCCCAGCACGCCGCCACGCAGTCCCACGCCGCCAGCTGGCAACCTGGTGCCCAAGCTGGAGCAGCCCGCAACGCCACCCTCCGAGTCGCCATCGCCAAGTCCttcgcccacgcccacgcccacacccacgccgAGACTGCCAAAGCTGCGACTCAATGCGCTGCTAGCCTCGGATCCCGCGCTGAAGCCCGATGCCAAGGAGTTGCACCTGTCGGACAAGCGATTGCTGGCACCGCCGCAGCAGATCAAACcagagccacaggcacaggcacagtcgCAGTCCAGCCTGCAGCCCGATCTCGTGGAGCCGCTGCTGAAGCCCGCGCGTTTCATGTGCCTGCCCTGCGGCATTGCCTTCAGCTCGCCCTCCACGCTGGAGGCGCATCAGGCGTACTATTGCTCGCATCGCAACAAGGACACGGAGGAGGCGGATGGCGCAGGTGCAGACAAAGCTGGAGGTGCAGATAAGACCACAGCGGGTGGAGGcactggcggtggcagcagcggtTCGGAGCCACCTGCTAAAGTGGCGCGCATCGGCAAGCAATACGCGTGCACCCAGTGCTCCTACAGTGCGGACAAGAAGGTGTCCCTGAACCGTCACATGCGCATGCATCAGACCTCACCGGCGCCCAGTCTGGGCAGCCTGGGATCTCTGGGCAGTCTGCCCAGTCTCACGGCAAATGGTGTGCCAGGAGCGGCAggtggcagcggtggcggcggcagcagcagcagcgccctcGAGGACTGTTCTAGTCAACAGCAAACGGACCGCTACTGCAGCGACTGTGATATACGCTTCAACAACATCAAGACCTATCGTGCACACAAGCAGCACTACTGCAGTTCCCGACGCTCCGACGGACGTTCGACGCCCaaaggtggagcagcagcagcagcagcagcagcagcagcggagggtGCAACAGTCGCCGCTCGAGAAGCGGGCGGAGCGGGCTCTGCGGGCAGTGCCtccgcggcagcagcggcggcaaccGGCAAACTCAGCCCACAGACGCGTAATAAGACACCCACGCCAGCcatggtggcagcagcagcagcggcggcagcagcagcagcggcagctgccacattGCAGGCGCCCACGCCTCAACCCTTTCTGGCGCTGCCCACGCATCCGATCATCATTGTGCCGTGCAGCTTGATACGAGCAGCGAGCATTATTCCAGGACCACTCCCCACACCCTCCTCGGGCATTGTGAACCTCGAGTCCACCTGCTTCACCGTGGACAATGGCGCCATCAAGCCGCTGGCCACTGCTTTGATAAGCAATGCGCTGGCCGGGAACATGAATCACTTTGTCAATTCGCTGCACATGGCCGCCCTGGAGCCGGAACGTCCCACAGCAGGCGCCGAGGGAGTAGGGAACCCGGAGCCCAAGAGCAGCAGTCCAGCGGAGCCCAAGCGCAAGGAAGCAGGCGGCAGTCGTGAATCTGCGCCACTCGATCTCTCGTTTCGTCGGTCGCCCATTTCCCTCTTGCAGCATCGCCAGCGGCACATAcgcaccgctgctgctgctgcggccgctgcgCTGCTGGACGTCGAGGAAGTGCTGCTGGGTGCGGGAAAGGAGAACGTGGAGTCTGCCCTCAGTCGAGCTGGCGGCAGTGTAACGCCCGAGCAGATCGTGTGTGCGCCCTCGCTGCCCAGCAGCCCCTCGATGAGTCCCTCGCCCAAGCGACGTGCCAGTCCAAGAAGCTCGGGTGCAGGCAGTGCCTCCTCCATGTCGCCGCCTGGCCTGAATCCACATCTGCTGGACATACGCTCCATGCTGCCAGCGGACTTTGGGCTGTCCGAgtcgctgctggccaagacCAATCCGGAGTTGGCGCTCAAGCTGGCGGCAGCCGCGGCGGCAGCTGTTGCAGCGGGTGGGAGTGCCGCGTCCTCGGTGGCTGCAGCGCCCGCGAATGTAggaaaccaacagcaacaacagcaacagccacagatcTACGTGAAGCAGGGCGTGTCCAAGTGCAAGGAGTGCAACATTGTGTTCTGCAAATACGAGAATTATTTGGCCCACAAGCAGCACTACTGCTCGGCGCGCAACCAAGAGCCAAGCGGCGATGGCAGCGACTCCAAGTCCGCCGTTTCGCCCTCGAATGCCGCAGCTGGCAACAATGTTGGCGCCTCCTCGGTGGAGACTACGCCCGTGGCCTATCAGCAACTCATTTGCGCCGCCTGCGGCATCAAGTACACTTCGCTGGACAATCTGCGCGCTCATCAGAACTACTACTGCCCCAAGGGTGGTGCCACGGCGGCCACAGCGCTGTCCGAGGCAACGAAGGAGAAGTGCGGCAAGTGCAAGACGCTGCACGAGCACGGACATCCCTGCCCAGCGCCACCTGCAGCCACACCGCTGACAGCGCCCACCAGCCTGCAGTCGGGCCTGTCCTCGGGCCTCAACAGCGTCAACAAGTGTCCCGTGTGCGGCGTGGTGAGTCCCACAGCGGCACTGGCACGCAAGCACATGGAGATGCATGGCACGGTGAAGGCATTCCGCTGCAGCATTTGCCAGTACAAGGGGAACACGTTGCGGGGCATGCGCACCCACATCAGGACGCACTTTGACAAGAAGACGAGCGACGTCAACGAGGAGCACTACATGACGTGCATCTTCGAGGAGGATAACTCGGGGCATGCCGCCGCTGTGTCGCAGGagctgccagcagcggcagtagtGACTGTGCCACAGCAGGAGCCACCCATGGAGCATCCGCCGCAGCTGTTTAACTGCGATTATTGCAATTATGCTTCCACCTACAAGGGCAATGTGCTGCGTCACATGAAGCTGCTGCATCCGCATGTGGCCATCAACTCTCCCTCAATATCCCCCGAGACACGTGAACAGGagacgccgctgctgcccagcGTCACGCCAAATGCGCACGAAGCATCCAATGGCGAGGCCATCAGCTTTCACATCAAGTCAGAGCCTGGACTGGACAATCCACCGACGCTGCACGAGAACAACAACTCTCCCATAGGCACACCCTTGCCGCACATCAAGGCCGAGCCGCTGGATATTGATGGCATGTCGCCCACACCgctgacactgccactgccaccgcctgtTGCCTCGCCGctggcagccgctgcagccgaGGCCATGAAGAAGTACTGCTCCGTGTGTGACATATCCTTCAACTATGTGAAGACTTTTCTGGCCCACAAGCAGTTCTACTGCAAGAGCAAGCCAGCAAGGCCCGAGGTGAAcgacagtcccagtcccaatgcCAATCACCTGGCGGGAGTGGGAGTCGGAGTGGGTGTAGGCATGGGCATGGTGAGTGGCCAGCCGCTGCAATCGCCCAGCGAACTGATGCTGATGCAAAAGAACAAGGAGAACCTGCAGGAGGCGGCCATTTGA
Protein Sequence
MSRRKQSNPKPLNKGDCSDTTEEMTVDSRDSKDLAAQEMGEEKQQQQQQQQQQEEQDEPMDLQDNNNNSDGEADTEDSLSVALPEETQAELGATEMEAEEATPHSSPSTPPRSPTPPAGNLVPKLEQPATPPSESPSPSPSPTPTPTPTPRLPKLRLNALLASDPALKPDAKELHLSDKRLLAPPQQIKPEPQAQAQSQSSLQPDLVEPLLKPARFMCLPCGIAFSSPSTLEAHQAYYCSHRNKDTEEADGAGADKAGGADKTTAGGGTGGGSSGSEPPAKVARIGKQYACTQCSYSADKKVSLNRHMRMHQTSPAPSLGSLGSLGSLPSLTANGVPGAAGGSGGGGSSSSALEDCSSQQQTDRYCSDCDIRFNNIKTYRAHKQHYCSSRRSDGRSTPKGGAAAAAAAAAAEGATVAAREAGGAGSAGSASAAAAAATGKLSPQTRNKTPTPAMVAAAAAAAAAAAAAATLQAPTPQPFLALPTHPIIIVPCSLIRAASIIPGPLPTPSSGIVNLESTCFTVDNGAIKPLATALISNALAGNMNHFVNSLHMAALEPERPTAGAEGVGNPEPKSSSPAEPKRKEAGGSRESAPLDLSFRRSPISLLQHRQRHIRTAAAAAAAALLDVEEVLLGAGKENVESALSRAGGSVTPEQIVCAPSLPSSPSMSPSPKRRASPRSSGAGSASSMSPPGLNPHLLDIRSMLPADFGLSESLLAKTNPELALKLAAAAAAAVAAGGSAASSVAAAPANVGNQQQQQQQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQEPSGDGSDSKSAVSPSNAAAGNNVGASSVETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGATAATALSEATKEKCGKCKTLHEHGHPCPAPPAATPLTAPTSLQSGLSSGLNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEDNSGHAAAVSQELPAAAVVTVPQQEPPMEHPPQLFNCDYCNYASTYKGNVLRHMKLLHPHVAINSPSISPETREQETPLLPSVTPNAHEASNGEAISFHIKSEPGLDNPPTLHENNNSPIGTPLPHIKAEPLDIDGMSPTPLTLPLPPPVASPLAAAAAEAMKKYCSVCDISFNYVKTFLAHKQFYCKSKPARPEVNDSPSPNANHLAGVGVGVGVGMGMVSGQPLQSPSELMLMQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00484660;
90% Identity
iTF_00601330;
80% Identity
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