Basic Information

Insect: Drosophila guanche
Gene Symbol: topi
Assembly: GCA_900245975.1
Location: NW:1013693-1017383[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.19 11 6.2 0.8 1 17 132 148 132 150 0.85

2 11 8.1e-06 0.00048 20.0 0.6 2 23 235 256 235 256 0.97

3 11 0.0003 0.018 15.1 1.6 2 23 283 304 282 304 0.97

4 11 0.16 9.6 6.4 0.0 2 23 371 392 370 392 0.90

5 11 0.00042 0.024 14.6 0.4 1 23 439 463 439 463 0.91

6 11 0.16 9.5 6.5 0.1 2 22 478 498 477 500 0.86

7 11 7.6e-07 4.5e-05 23.2 1.9 1 23 523 545 523 545 0.95

8 11 0.00079 0.046 13.7 0.9 1 23 551 576 551 576 0.94

9 11 0.37 22 5.3 1.7 1 23 582 604 582 604 0.88

10 11 3.2e-08 1.9e-06 27.6 0.4 1 23 610 632 610 632 0.99

11 11 0.0021 0.12 12.4 2.1 1 23 638 661 638 661 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.19	11	6.2	0.8	1	17	132	148	132	150	0.85
2	11	8.1e-06	0.00048	20.0	0.6	2	23	235	256	235	256	0.97
3	11	0.0003	0.018	15.1	1.6	2	23	283	304	282	304	0.97
4	11	0.16	9.6	6.4	0.0	2	23	371	392	370	392	0.90
5	11	0.00042	0.024	14.6	0.4	1	23	439	463	439	463	0.91
6	11	0.16	9.5	6.5	0.1	2	22	478	498	477	500	0.86
7	11	7.6e-07	4.5e-05	23.2	1.9	1	23	523	545	523	545	0.95
8	11	0.00079	0.046	13.7	0.9	1	23	551	576	551	576	0.94
9	11	0.37	22	5.3	1.7	1	23	582	604	582	604	0.88
10	11	3.2e-08	1.9e-06	27.6	0.4	1	23	610	632	610	632	0.99
11	11	0.0021	0.12	12.4	2.1	1	23	638	661	638	661	0.96

Sequence Information

Coding Sequence: ATGGATGAAGAGAATTTTGGGATCTTTGAGGAGCCGGGTGAGTGTACCCTGGCGGAAATCGAAGTCGGCGACGAGTCGCAGTTGAATTACAGCCACATGCCGGGCGCTACAGTGCTGGCGTCCAGCGACCAGGAGGGACTGGTCCAGTTCTTTGCCAGGCCACCGCCTCCCATCATGCAGATGTCAACTGAGGTGATGGTTCAGCGCACTCTGGAGCATCCAGCACTGAAGCAGATACTCCAGGAAGCCGACGGTCAGCCAGATTTTGATCCAGCAGCGgagcaaatgaaaattcgCGATTTCCTAGCGGGCGTCACCAACAATAAGATGACCACAGAGGAGTCTGTCTTTCAAGCACATCGCATGAGCGCGCCCACGAACGGGCCACGCGTCTACAAATGCCGTGACTGCGGCGGCACGTTCGACTCTTTGTACTATTATAATCACGTTTGCTTGACCGAGAATGCCGTAAAGCCAAACTTCGAGGCAGCTGTACAGCAGCAGGATAAGACACGATCTGTGAAACTGTCGACAGCGCCGGCAATTGTCCCAGCGCCTCGCTATATTCGAGGCAGCGAGCGCGTCATCTTGGAAAATCAAATACGCCTGCGGCGTTACATGAAGGACGAGCTGAAGTACGATGTCACCACGGGCATTGACAATTCGCTGGGGCTGTCCAAGAAGAAGGGCAAGCAGCCCAACGAGTGCTCTATATGTGATCGGCAGTTCGTGCATGCCTCTGGCCTGGTACGCCACATGGAGAAGCATGCCCTGAACCTGATCGCCCCACAGGCGAATGCGCCATCAATCCCACCTCCGCCTGCCCCCGGCCTAGCTGTGGTCACAAAATGCAACGATTGTGGCCGCATCTTTTATGATTGCAAGCTGGCCATGCGCCATGTCCGTGTTCATTATCCCGAACAACCGAAAATATGCGAACCCCTCATTGACAAGAACGTatcacaaaagaaaaagtttattAGGCGCATGCTAAAAGGGGACTGGCTTTTCCTGTGTGTGTACGCAAAGAAACGGAGCATCGAGCAGAAGCAGGCGAAGCTAGCGTTGGAGGCCGGGCTATTTTCTACACTGATCCTGGGTAGCGTGCTGCAGTGCGAGTTCTGTGAGTTCGTATTTGCGGATATTGAAAAGCTGCTCGTCCACTCGGCCGCTCACGTGGTGGAGAAGCGCTTCGAGTGCACCGCCTGCGACATTACGATGAACACCGCCAAGGAGGCCAGTGTCCATTTCCAGAGCGACTGCATCTTTATGCGCGAAGAACAGAAGCGGCTGGATGTGTCTCTCTTTCGATATTTTGTGTGCAATGTGTGCGAGCAGAAGTTTTCCACTGCCGACGTGCTGCAGGAACACCGAAACATGTACTACCATTACTTTCCACGCCTCAGCGCGGACGGGAGTGCACTGTTGCTGCCCTGCGAGTATTGCGATGTCAATTTTACGGCTGCCCACGAGGTGGAGGCGCACAACCTGGAGAAGCATGTGAACAAGAAGCGGCGCGAAAAGGAGACGCGGATGAATGGCGCCGGCAACGGCCGCCTTCGCCAGTACCTGTGCGACGTCTGTGGAAAGTCGTACACCCAGTCCAGTCATTTGTGGCAGCACCTGCGCTTTCACCAGGGTGTCAAGCCATTTGCCTGCCAAGAGGCCAATTGCGGTAGAAAGTTCACCATTCGTCCGGATCTCAACGATCACATTCGCAAGTGCCACACTGGAGAGCGTCCGTATCATTGTCTGGTGTGCGGCAAGCGTTTCCTCACCGGATCCGTCTTCTATCAGCACCGTCTGATACATCGCGGAGAGCGGCGCTACGAGTGTGAAGAGTGCGGCAAGCGATTCTACAGAGCCGATGCCCTTAAGAACCACCAGAGGATCCACACCGGCGAGAAGCCATTTAGCTGCCTCTTTTGCACCAAGACTTTCCGCCAGCGCGGAGACCGGGACAAGCATATACGTGCACGACACTCCCATTTGAACGCCAACACGCGCCTCAtgatgcagatgcagaagaTCCAGCTGGAGACGTCGGATGCTATAAAGTCCAGAATGCGTGACATTCCAATGGGCGAGGGTGACGGCTACTCGACATCCATGTATCAGGTATCAGGTTCTCAGGAAGATGGTGAAATGCAACTAGTTACGGATGAGCAGGAACTAAGATATTACGAGCCAATGGACGGATTTGAGATGCAGCAGTACGTGGAGGAGGCTGGGCCCAATCTCATGAATGAAGTCGAATATGAAGAGGTAATTGTGTACGAGAACACAGAGGAAGAGCCAGCTTTGTACGAGAACCCAGAGGAAGAGCCAGCTTTGGCAATTTCTTATGAACCCCAGCCAGAACCACAACAAATGGAAGAAGAGATTCCAGTGAAACCCGAAAGACAAAAGCGTAAGATTGTGGTGGTGAAGAATAATCCATCTCTACCGCTTTATCCAACTATGTAA
Protein Sequence: MDEENFGIFEEPGECTLAEIEVGDESQLNYSHMPGATVLASSDQEGLVQFFARPPPPIMQMSTEVMVQRTLEHPALKQILQEADGQPDFDPAAEQMKIRDFLAGVTNNKMTTEESVFQAHRMSAPTNGPRVYKCRDCGGTFDSLYYYNHVCLTENAVKPNFEAAVQQQDKTRSVKLSTAPAIVPAPRYIRGSERVILENQIRLRRYMKDELKYDVTTGIDNSLGLSKKKGKQPNECSICDRQFVHASGLVRHMEKHALNLIAPQANAPSIPPPPAPGLAVVTKCNDCGRIFYDCKLAMRHVRVHYPEQPKICEPLIDKNVSQKKKFIRRMLKGDWLFLCVYAKKRSIEQKQAKLALEAGLFSTLILGSVLQCEFCEFVFADIEKLLVHSAAHVVEKRFECTACDITMNTAKEASVHFQSDCIFMREEQKRLDVSLFRYFVCNVCEQKFSTADVLQEHRNMYYHYFPRLSADGSALLLPCEYCDVNFTAAHEVEAHNLEKHVNKKRREKETRMNGAGNGRLRQYLCDVCGKSYTQSSHLWQHLRFHQGVKPFACQEANCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHIRARHSHLNANTRLMMQMQKIQLETSDAIKSRMRDIPMGEGDGYSTSMYQVSGSQEDGEMQLVTDEQELRYYEPMDGFEMQQYVEEAGPNLMNEVEYEEVIVYENTEEEPALYENPEEEPALAISYEPQPEPQQMEEEIPVKPERQKRKIVVVKNNPSLPLYPTM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00601237;
90% Identity: iTF_00601237;
80% Identity: -