Basic Information

Insect: Drosophila guanche
Gene Symbol: -
Assembly: GCA_900245975.1
Location: NW:5774598-5776584[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 3.5e-06 0.00021 21.1 0.0 1 23 224 247 224 247 0.96

2 8 2.4e-05 0.0014 18.5 2.4 2 23 269 291 268 291 0.94

3 8 6.1e-05 0.0036 17.2 0.5 2 23 316 336 316 336 0.96

4 8 2.3e-06 0.00014 21.7 1.9 1 23 342 364 342 364 0.99

5 8 3.8e-06 0.00022 21.0 2.0 2 23 371 392 370 392 0.97

6 8 3.7e-08 2.2e-06 27.4 0.8 1 23 398 420 398 420 0.98

7 8 0.0012 0.072 13.1 0.2 1 22 426 447 426 450 0.91

8 8 0.0016 0.092 12.8 1.0 1 22 516 537 516 540 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	3.5e-06	0.00021	21.1	0.0	1	23	224	247	224	247	0.96
2	8	2.4e-05	0.0014	18.5	2.4	2	23	269	291	268	291	0.94
3	8	6.1e-05	0.0036	17.2	0.5	2	23	316	336	316	336	0.96
4	8	2.3e-06	0.00014	21.7	1.9	1	23	342	364	342	364	0.99
5	8	3.8e-06	0.00022	21.0	2.0	2	23	371	392	370	392	0.97
6	8	3.7e-08	2.2e-06	27.4	0.8	1	23	398	420	398	420	0.98
7	8	0.0012	0.072	13.1	0.2	1	22	426	447	426	450	0.91
8	8	0.0016	0.092	12.8	1.0	1	22	516	537	516	540	0.91

Sequence Information

Coding Sequence: ATGCAAAATCAAGTTTTTAATATTAACAATCTAAGCTGCCGTGTTTGTCTGGAGACAAACGAGGACGCCTTGCGTCTACACGACGAGATCCAGTACAATGAGCTGAACTTTGAGTTGTGGCAACTGCTGGAAACCGTCTCCAAAGTGAAGTGCACTTGGAACGAAGCAGACATGCCGACCCGCTTGTGCCAGAAGTGTACACACCGCTTGATAGCTGCCTATGAGTTCATCCTCGATGTGGAGAATGCACAGCACACGCTGCAGAACTTGTATCTGCAGCCAACGACagcgactacgactacgactctGATGAAGGATCCCgagcagatgcagatggagaTTCTGGGAGTGTGCAGTCAGGACGAGTTTCTGTCCGTCCTCTGTGACACTAAGGAGGTGGCTGTGACGATGGATGCAGAGGACACCGCTGAAGCTGTGGTGGATGTGCAATTTTCACAAGCAGAAACCATTGTCGAGTCAGTCTATGGATCAGAGCAGCTAGAAGAACTGGAGACGGGTATACCATTTGAGGCAGAAGGCGTGGAGGTTACACAAAGTGTGGATGAAGAAAATTTCGATGTGAAAGCGGATAAACAGGAACCTCCGGGTGGGACAAAGCTGCGTTCCTCACAGCTGGGCAGTCGGCTAACCCACTCACAGAATTTCATCTTCAAGTGTGCCATTTGTCCGCGTGTCTTTGCCAAAAATGATTCGCTCGCTCGGCACATTGCCGTTGCCCACACTCAGACAGCGGACGTGGCCGCCCAGGAGCTGGCAAACGAGAGCAGTGGAAGCGGCGTGCTCACCTGCAAGCACTGTCCACGCATTTTGAAGCGTCAGGACACACTGCGTCGTCACATGCAGGCATTCCATCCAGAGGAAGCGGCCAAAGATGAGGCTGAGTCAACTGGCAGCTCACAGCGGAAGCGCACCGCCAAGCGTCGTGAGTGCCCGCACTGTGGAATTAGTTTTCCCACCTCCAGCCTGACCATCCACATACGCCGGCACACGGGCGAGTATCCGTACAAGTGCGACCAGTGCGAGAAGGCCTTTCCGCGCAGCCAGGATCTCAGCTTGCACATGCGACACCACACGGGCGAAAGGCCCAGCGAGTGCAAAATCTGCTCCAAGAAATTCATATCCCAGAACAAGCTGTCCCGACACATGCGCCTGCACACGGGCCAGCGTCCGTATGCCTGCGACAAGTGTGACAAGAGCTTCGTGCAATCCAACGACCTAAAGATCCACATGCGCCGCCATACAGGCGAGCGGCCGTACAAGTGTGATGTTTGCGGGGACAGCTTTGTCTCGGGCTCCCTGCTGAACGTGCATCGGAATCAGAAAGGTCACATGGCCACAAGTGGAAACCTGAGCTCTGGCGACACCACCACTGAAGATCCGTACTTGAATGCACGTGTCAGCAAGCGTCGCGCGGAGGATATTGAGCGAATGCGGCTCAAGAGAGATGCTGTGGATGGCCTCAATCAGCCACAGATGGCAACGGAGACGATACAGTACTCGCCTCCAGAGAAGCCGCTGCTGATCTACAAGTGTGGCGTCTGTGAGTGGACCTTCAAGAGCGGCGCCTGCCTAACCATTCATCGCAATAATATGTCCCACTACGAGATTGGCAAAGTCGATTACGGCGATCCATTTTCAAAGGTAGTCAAGCGGCATAGCTAA
Protein Sequence: MQNQVFNINNLSCRVCLETNEDALRLHDEIQYNELNFELWQLLETVSKVKCTWNEADMPTRLCQKCTHRLIAAYEFILDVENAQHTLQNLYLQPTTATTTTTLMKDPEQMQMEILGVCSQDEFLSVLCDTKEVAVTMDAEDTAEAVVDVQFSQAETIVESVYGSEQLEELETGIPFEAEGVEVTQSVDEENFDVKADKQEPPGGTKLRSSQLGSRLTHSQNFIFKCAICPRVFAKNDSLARHIAVAHTQTADVAAQELANESSGSGVLTCKHCPRILKRQDTLRRHMQAFHPEEAAKDEAESTGSSQRKRTAKRRECPHCGISFPTSSLTIHIRRHTGEYPYKCDQCEKAFPRSQDLSLHMRHHTGERPSECKICSKKFISQNKLSRHMRLHTGQRPYACDKCDKSFVQSNDLKIHMRRHTGERPYKCDVCGDSFVSGSLLNVHRNQKGHMATSGNLSSGDTTTEDPYLNARVSKRRAEDIERMRLKRDAVDGLNQPQMATETIQYSPPEKPLLIYKCGVCEWTFKSGACLTIHRNNMSHYEIGKVDYGDPFSKVVKRHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603509;
90% Identity: iTF_00601208;
80% Identity: -