Dgua005657.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila guanche
Gene Symbol
su(Hw)
Assembly
GCA_900245975.1
Location
NW:3124699-3129849[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00053 0.031 14.3 2.2 1 20 216 235 216 237 0.94
2 12 2.2e-06 0.00013 21.8 0.4 3 23 288 309 286 309 0.93
3 12 0.032 1.9 8.7 0.0 1 23 315 337 315 337 0.95
4 12 4.3e-07 2.5e-05 24.0 2.4 1 21 344 364 344 365 0.95
5 12 4.9e-06 0.00029 20.7 1.0 2 23 377 398 376 398 0.96
6 12 0.00022 0.013 15.5 6.3 1 23 409 431 409 431 0.99
7 12 6.4e-05 0.0038 17.2 0.9 1 23 437 459 437 459 0.97
8 12 7.4e-06 0.00044 20.1 0.7 1 23 465 487 465 487 0.98
9 12 1.2e-06 7e-05 22.6 3.0 1 23 493 515 493 515 0.98
10 12 1.3e-05 0.00077 19.3 0.5 1 23 519 541 519 541 0.97
11 12 5e-05 0.0029 17.5 0.2 1 21 549 569 549 573 0.92
12 12 0.00076 0.045 13.8 1.4 3 21 593 611 591 614 0.94

Sequence Information

Coding Sequence
ATGAGCGCCGCCGCCAAGGAGGGAAGAAAGACAGATGGCTCCTCCGAAAGGGGCAGCAGGTCTAGCACAACTGTAGTGAAAATAATTGGCGTGGACAAACTATGCTTGCCCAGAGTCAAGGGCCCGACGACGCGCATGAAGCTGCTGAACGATGTCGCCGCTTCTGGCAAGCCGGAGAAACGTGGGAGCCTTGGCGGTGCTCGCATTAAAATTCTCAATGAGGACGCTTTGTGCTCCCCGAAAGCCGACAAACGCAGCCCTCAAAAGACAGTCAGTCCCTCGGGCTCTGTGAAGATATTAAACGAGAAGCGCCTGGCTCCATCCACTGCGACGGCTGTGGAGACGACAAAGATCAAGACGTCCCCCACcaaacagaagaagaagatgGATCATTATGTGCTGCAGGCCGTCAAGGCCGAGAACAGCAAGGCAGACACCACAGCCAGTGTATCGGAGGAGGACGAGAGCATTGCTTTCATCCTTGCCGATGAAGATGAGGCAGAACCAGTGGCGGGTCGAGCCAATGGCGAAGAGATTGTAGTTTCAAGTCCAGAAGAGGACAATgaagacgatgacgatggtGAGGGCGATGCCGCTGTTGAGCGCACCGGTGGCAGCCAAGGAGCCATAAAGGAAATGGTTGAACATGTTTGCGGCAAGTGCTACAAGACATTCCGCCGTGTGAAGAGCCTTAAGAAGCACTTGGAATTCTGTCGCTATGACAGTGGCTATCATTTGCGCAAGGCGGACATGCTGAAGAACTTGGAGAAGATTGAAAAGGATGCTGTGGTGATGGAGAAAAAGGAcatttgcttctgctgcagcgaGAGCTACGACACCTTTCATTTGGGCCACATCAATTGCCCCGATTGTCCAAAGTCATTCAAAACGCAGACCAGCTATGAACGTCACATCTTCATCACGCACTCGGAATTCAATACTTATCCCTGTtccatttgcaatgcaaatttgcGCAGCGCCGCATTGCTGACGCTTCACGAGGAGCAGCACAAGTCACGTGGCAAGCCATATGCCTGTAAAATCTGCGGCAAGGACTTTACACGCTCCTATCACCTGAAGCGTCACCAGAAGTATTCCTCTTGCTCTGCCAATGAGAACGATACCATGAGCTGTAAGGTGTGCGATCGTGTCTTCTATCGCCTCGACAATCTGCGCTCGCATCTGAAGCAACATTTGGGCACTCAAGTGGTGAAGAAACCAGAGTACATGTGCCACACCTGCAAGAACTGCTTCTACAGCCTGTCAACGCTTAACATACACATACGCACCCACACTGGGGAGAAGCCATTCGATTGCGATCTGTGTGACAAGAAGTTCTCGGCCTTGGTGGCTCTCAAGAAACATCGACGCTACCACACCGGCGAGAAGCCCTACAGCTGCACAGTGTGCAATCAATCCTTTGCTGTGAAGGAGGTGCTCAATCGCCACATGAAGCGACACACCGGAGAGCGTCCGCACAAGTGCAACGAGTGTGGCAAGAGCTTCATCCAGGCCACCCAGTTGCGCACCCATTCCAAAACCCACATACGTCCCTATGCCTGCGATTTGTGTGATGAAAAATTCAAGACAGAAAAGCAACTCGAGCGCCACGTTAAGGAGCACACGCGGCAGAAGCGCGCCTCTTTCGCTTGCACTGATTGCAAGCGTACCTTCCGCACCACAGCTCTACTTAAGGAGCACATGGATGCCGGCGATCATTCGCCCAAACCACAACGAGCCAAGCGCTCAATCACCAAGGTTATCGAGCGCACAGACTGCGCCATTTGTGACAAGAACTTCGACAGCACCGAGACCTTGCGCAAGCATATTCGCTGCGTTCACGAATGCGATCCGGATGATATCTTTGGCGTCGAACCGCCAGCAGCAAAGCGCAGCAAGTCGAAAAAATCTGCCGAAGAAGAGGAGGATACTGAAATCGTTGATCTGAATGCATCGGCGGGTTCGCTGATTTCCAGCCAAACCGATGGCAATGGAGTTGTGGTCAGGGAGTTTCTGGTCGACGATGGCAGTGCCCAGACCATCTTGCTGGAGAACGAGACATACACAATTCTGCCCCTGGATGATGGGGGCACCAGCAGCGACCAACAGGTGCCCACTAAAGGGGCGGACAGTGTCAAGCCGGAGGCCAACAAAAGCGAGACCAAGAAAGCTGCTGTTTCCCCGGTGGTCAAGAAGGAGCAGCGAAAATCACTGGCGGCCAGCTTGGCCGCAGCCATTGCCGATAATATGGAGGAGCCGACCAGTGAGGATGATTTTAGCGGCAATGTACTCACCGAATGCGACCTGAAGCTCAAGGAGAATGTTGCCAAATTGATTGACATGCTGGTCGACCCACACGTCCTCAAGAAGTACGGCTGGCCCAACACCTCCGAGGAGACAATGCTCTGCAAGGTGATCGAGAACTGTGGCCATGATCTCAGCAAGGATGAGGAGAACTACGCTGAGCTGGAATACGGCGATCGTATGCGCGAATATTGCAAACTTCTCTTCACTGTGGTCATTCACAATGAGTCCATACGGTCCCTGCTCAACAATTTCCCCATCGACGATGTCATCGAGTATGTGCTAGGAGACGAGGACcaagacgatgatgaggaggaggatggcAAGAAGAAAGACACTGATGCTGCAGTAGACAACAAGTCGGACACTGCAGAGACCCCAGCAGACGATAAGGATTAG
Protein Sequence
MSAAAKEGRKTDGSSERGSRSSTTVVKIIGVDKLCLPRVKGPTTRMKLLNDVAASGKPEKRGSLGGARIKILNEDALCSPKADKRSPQKTVSPSGSVKILNEKRLAPSTATAVETTKIKTSPTKQKKKMDHYVLQAVKAENSKADTTASVSEEDESIAFILADEDEAEPVAGRANGEEIVVSSPEEDNEDDDDGEGDAAVERTGGSQGAIKEMVEHVCGKCYKTFRRVKSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFNTYPCSICNANLRSAALLTLHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQSFAVKEVLNRHMKRHTGERPHKCNECGKSFIQATQLRTHSKTHIRPYACDLCDEKFKTEKQLERHVKEHTRQKRASFACTDCKRTFRTTALLKEHMDAGDHSPKPQRAKRSITKVIERTDCAICDKNFDSTETLRKHIRCVHECDPDDIFGVEPPAAKRSKSKKSAEEEEDTEIVDLNASAGSLISSQTDGNGVVVREFLVDDGSAQTILLENETYTILPLDDGGTSSDQQVPTKGADSVKPEANKSETKKAAVSPVVKKEQRKSLAASLAAAIADNMEEPTSEDDFSGNVLTECDLKLKENVAKLIDMLVDPHVLKKYGWPNTSEETMLCKVIENCGHDLSKDEENYAELEYGDRMREYCKLLFTVVIHNESIRSLLNNFPIDDVIEYVLGDEDQDDDEEEDGKKKDTDAAVDNKSDTAETPADDKD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00487439;
90% Identity
iTF_00473938;
80% Identity
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