Dfuy000564.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila fuyamai
Gene Symbol
tsh
Assembly
GCA_018153365.1
Location
JAECXW010000883.1:4940167-4946903[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.00026 0.021 15.3 0.5 1 21 353 373 353 377 0.92
2 3 0.00033 0.025 15.0 0.5 2 22 466 486 465 489 0.90
3 3 1.9e-05 0.0014 18.9 0.3 2 22 533 553 532 556 0.90

Sequence Information

Coding Sequence
ATGTTGCATGAGGCTTTGATGCTCGAGATCTACAGACAGGCGCTAAATGCCGGAGCCCTGCCCACAGCTCGACCGCGTTCCACGGAGTCGGCGAATTCCAGCGAGCGCTGTCCGTCGCACGACTCCAACTCCTCGGACAATGGTGGTGGTGGAGCCGGCAGCGGCGGCGTGGGTCACCGGATGGACGGCGCCTTGTCCGCCGGAGTCATGCCCGGAGTGGTACCCACCACCCTGCACTCGACATTCCCGGCAGTGCCGCAGTCCCTGCCCGCTCAGCCGCCCTCGATGGAGGCGTACCTGCACATGGTGGCGGCGGCCGCCCAGCAGTATGGGTTCCCCTTGGCTGCTGCCGCAGCGGCGGGGGCAGGGCCACGCCTGCCACTCCCACTGGCAAATGAGGCGGCGGCCCCCTTCAAACTTCCCCCGCAGGCTTCGCCCACTGCGTCGAGTAATAACTCGGAGGCCCTGGACTTTCGCACCAACCTGTACGGTCGGGCGGAATCGGCTGAGCCCCCAGCCTCGGAAGGTGAGGATGAGGACTTTGATGATGGTGCCAACAATCCCCTCGATCTCTCCGTGGGCACGCGGAAACGTGGCCACGAGTCGGAGCCACAACTGGGACACATCCAGGTCAAGAAGATGTTCAAGTCGGACAGCCCTCCCGCGAATCCCGTGGCCCCGCCTTCAGCCAGTCAGCTAATGCCAGGAGTTAATCCGTATCTCGCGGCCGTGGCGGCTGCCAATATTTTCCGAGCGGGTCAGTTTCCCGACTGGAACGGCAAGAGCGACCTGGTGGTGGATCCCCTCGAGAAAATGTCTGATATTGTGAAGGGAGGAGCGAGTGGAATGGGCAAGGAGAAAATGCACTCCTCCAAGGCCACACCTCCACAGGCAGCAGCACAACCACCAAAGAGTCCAGTTCAACCACCACCGCACCAGAACTCCGAGTCCGGAGGAGGATCAGGAGGCGGTGGAGCAGGTGGTGGCGGAGTGACCAAGGCCAGGCACAACATTTGGCAATCGCACTGGCAGAACAAGGGAGTGGCCAGCTCGGTTTTCAGGTGCGTGTGGTGCAAGCAGAGTTTCCCCACCTTGGAGGCCCTCACCACCCACATGAAGGACAGCAAGCATTGCGGGGTAAATGTGCCACCATTTGGCAATCTCCCGAGTAACAATCCCCAGCCCCAGCACCACCATCCAGCCCCTCCGCCACCACCGCAGAACCACAGCCTCCGAAAACACGGCTCAGGAAGTGGATCCAACCACTCACCCTCGGCGAATGTGAAGAACGCCTTCCAATATCGAGGAGATCCACCCACGCCGCTGCCCAGAAAGTTGGTCAGGGGCCAGAATGTTTGGCTGGGCAAAGGGGTGGAGCAGGCCATGCAGATCCTCAAGTGTATGCGGTGCGGTGAGAGTTTCCGTTCCCTGGGTGAAATGACCAAGCACATGCAGGAGACGCAGCACTACACAAATATCCTGTCCCAGGAGCAGAGTATCTCCATCAAATCAGCGAATGCAAATGCCAACTCGGATGCCAAGGACAGTCACAACAGTCTGAGTTCCGAGGAGAGTCGCACCCTCAGTGCCGTGCTCACCTGTAAAGTGTGCGACAAGGCCTTCAGTTCTTTGGGGGATCTGAGCAACCACATGGCCAAGAACAACCACTACGCCGAACCGCTCCTCCAATCCGCGGGTGCTCGCAAACGGCCAGCTCCTAAAAAACGCGAGAAGTCACTGCCTGTGAGAAAGCTCCTTGAAATGAAGGGTGGAGCCGGAAATCAGGAAGATCTGTTGAACGAAAAATCCGCTGTGCAGGGAAAACCTGGTCTGGGACCCGGTGGAGGCGATAAGAACGATGCCGCTCTTTTCGCCGAACGAATGCGGCAGTACATTACGGGGGTGAAGTCCCCCGAAGAAATGGCCAAAGTGGCTGCTGCCCAACTGCTGGCCAAAAACAAATCCCCCGAGTTGGTGGAGCAGAAGAATGGCAGTGCCAAGGCACCGGGCTCCTCCTCTGTGCTAAGTGCCATCGAGCAGATGTTCACCACCAGCTTTGATACGCCACCCAGACACGCCAGCCTGCCAGCTAGTAGTCCCTCCAACTCATCCACCAAAAACACCTCGCCAGTGGCTTCCAGTATACTGAAACGTTTGGGGATCGACGAGACCGTGGACTATAACAAACCCCTGATCGACACCAACGACCCCTACTATCAGCATTATAGGTACACCAGCAGCGAGAGGAGTGGCAGTGAGTGCAGTGCGGAGGCCAGGCCGAGACTGGATGCCCCCACTCCCGAGAAACCACAGCAAACAGGGGGAGGACACGAAGAGGAGTCCACCAAGCCGGCAATAAAGCAGGAAAGGGAGCTGGAGTCGGAACCCATTAAAATGGAGATCAAGTCTGAGCTTGCCGATGAGCAGAACGAAGTCGAGGAATCATCCAAAATGGAGGCGACTCTGGTTAATGGCACTGCCGTCAATAATAACAATAACAACGTGGAAAGGAGCTCTCCGAAGACACCTTCATCGGCGGCCAGTCCCCAATCTAGGCTGCTACCGCCCCGAAGTCCTGCCGAGAGTCAGAGATCAGCTACACCAAAGTCACCCGCCTCCAGCCACAAGTCCTTCGACGGCAGTTCGGAGGGCAACAAGAAGTATCCCAGTGATTCGCTGAACGCTCTGTCCTCCATGTTCGATTCCTTGGGCAGCAGTGGAGCAGGGGCTGCCAATACCAGAGCCAAGCTGGCGGCTGCAGTTGCCGCCGGAGGATCCGAGTCGCCGGAGAACCTCAGCTCCGGTGGAAACTCACTGGCGGCCCTGCGACAATTCTGCGTGAAGAAGGAGAAGACCGCCTAA
Protein Sequence
MLHEALMLEIYRQALNAGALPTARPRSTESANSSERCPSHDSNSSDNGGGGAGSGGVGHRMDGALSAGVMPGVVPTTLHSTFPAVPQSLPAQPPSMEAYLHMVAAAAQQYGFPLAAAAAAGAGPRLPLPLANEAAAPFKLPPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEDEDFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANPVAPPSASQLMPGVNPYLAAVAAANIFRAGQFPDWNGKSDLVVDPLEKMSDIVKGGASGMGKEKMHSSKATPPQAAAQPPKSPVQPPPHQNSESGGGSGGGGAGGGGVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPAPPPPPQNHSLRKHGSGSGSNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSANANANSDAKDSHNSLSSEESRTLSAVLTCKVCDKAFSSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLLEMKGGAGNQEDLLNEKSAVQGKPGLGPGGGDKNDAALFAERMRQYITGVKSPEEMAKVAAAQLLAKNKSPELVEQKNGSAKAPGSSSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKPQQTGGGHEEESTKPAIKQERELESEPIKMEIKSELADEQNEVEESSKMEATLVNGTAVNNNNNNVERSSPKTPSSAASPQSRLLPPRSPAESQRSATPKSPASSHKSFDGSSEGNKKYPSDSLNALSSMFDSLGSSGAGAANTRAKLAAAVAAGGSESPENLSSGGNSLAALRQFCVKKEKTA