Basic Information

Gene Symbol
RREB1
Assembly
GCA_035042345.1
Location
JAWNLM010000270.1:323015-328739[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.026 1.8 9.1 0.8 1 21 261 281 261 283 0.93
2 12 0.00024 0.017 15.5 0.2 1 23 293 315 293 315 0.98
3 12 0.00018 0.012 15.9 7.2 1 23 321 343 321 343 0.98
4 12 0.17 12 6.5 1.7 2 20 576 594 576 596 0.93
5 12 0.011 0.79 10.2 0.2 1 23 743 765 743 765 0.97
6 12 9e-06 0.00062 20.0 0.7 1 23 775 797 775 797 0.99
7 12 0.0006 0.042 14.3 2.0 1 23 803 826 803 826 0.97
8 12 6.3e-05 0.0043 17.4 0.3 2 23 1121 1142 1120 1142 0.97
9 12 0.23 16 6.2 5.1 1 23 1148 1171 1148 1171 0.96
10 12 6.8 4.7e+02 1.5 3.4 1 23 1290 1313 1290 1313 0.78
11 12 0.0061 0.42 11.1 0.5 3 23 1370 1390 1368 1390 0.96
12 12 1.3 88 3.8 0.6 1 14 1396 1409 1396 1414 0.85

Sequence Information

Coding Sequence
ATGCTcgccacacagcagcagcaacagcagcaacaacaacaacaatcgcacacagcagcagcagcagcaacacttgaGGAAGCTCGCGATTTAGGCTTAATGGAGACGCGACAACGTCGCGATTCGAGTACATCTGAATCCTCGCTGGAGCATTTGGATTTGGGTCGCACGCCAAAAaagttgagcagcagcagcggcgcacCGCAGCCGACGTCGACGCCGCACGACACAGCAGTGACAGCGACGTCGCGCAAGCGGAAACTGcgacagcaacaccagcagcagcaacatttgccgCTCTCCGATGAGgaccagcatcagcagcaacagcaacaacagcagcagctgttggacTCTTCAGCGCAACGACCGCGTCACAAGCAGCGACGCAGCGCTGTTCCTGCCGCCACCAGCGCCAGCATCGTTGTTGACTACAGCGCCAGCGGAGACGCCAGCTCGCTGCGCAAAAAGTTTCGACTGAAtcgcagcagcgccagcagcaatgCTGCCAACGGTGATTTATCCGAGTCTGGCTTCGTCGATGGCAGCGCCCTCAGTGGTTATCTgcttggcaacaacaacaacaataacaacaacaacaataacaacaacaacaatattagtagtagtagcagcagcagcgcagtcgCTCagtcagcagcatcagcagcagcgtcggcAGCGCAGCATGCGTCAAGCGTTAGCAGCTCGGGCGGCTCCTCGCCACAGGGCCTTTCGAGTGCCGAGTCGGGCATCGGTGCCGGTGATGAGcacatgaaatatttgtgcCCCATCTGTGAGGTCGTCTCGGCCACTCCCCACGAATTCACCAATCACATTCGCTGCCACAACTACGCCAACGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTGTCGTCGGCATCCTCGCTGGACCGGCATGTCCTGGTGCACACTGGAGAGCGTCCGTTCAACTGTCGCTATTGCCACTTGAACTTCACAACCAATGGGAACATGCACCGACACATGCGCACCCACAAGCAACATCAGGcctcgcagcagcagcagcaacagcagcacagctcgcagcagcagcaatcaagccaacagcagcagcagcagcagcaggcacagtcgcagtcgcaacagcagcaacagcgacgccAGCAACATGCGggtggagctggagcagctggcCCCGAATCGGGATCGGCACAGTTGTTGACAACGCGAGCCGAGAGCTATGAGAGTGATGCTAGCTGCTCGACGGATGTGTCCAGTGAGCTGAAcagtcacagcagcaacagcaatcaatccaaccccaacaacaatagccacaaaacgaacaacaataacaacaataagaacaacaacaacaacaacaatgaggaTGAGATGGAGCTGGAGGATGAGCAGCTAGTGTTGAGCAGCAAACAGCGACGCCTAAAGGCAGtcctaaacaacaacaatataattaGGGATGAGGAGCACGAGAATCGGGCGGATGATGATTCGGATGTGGACAGCGTTGATAGTGTTGCCCAGGTGATAACAAGCACACCAGATGTGGCCACGTTGCTCGCCTCGGGCGGCACCTCGCCGAGCCACTCGCATTCGGAATCGCATTCaccgccactgctgctgcagagtTGCCCCGCCTGCAATTCGGGTGAATTTGAATCTGTGCCAGCGTTGTGCGCCCATCTGGATGCCGAGCATGCGGACATACCGGCCAAGTGTCGCGAATGCGAGGTGATCTTTGCCACACATCGACAGCTGCAGGCGCACAGCTGTCGTGGATTGCCACCGCTCCTTGGTGTCAGCTCATCGCCACTGCACAAGCAGGAGGAGAACGaactggaggaggaggagcagcaacagcagcagcacgaggAGGACCATGaacagcaacacaagcagGAGGAACAGGAGCAGGCTGAGCAGCGCGAATGTGAAGATTTCTTCCAGCAGCTGTATCTGAAGAATAAATCGTCAGCAGCGCTCCTGCCATCTCCGATCAAACATGAGCCGGCGGATCAGCGACAGGATCTGGCCGACATTCAAAGCATTCTCAATATGACCAGTTCCAGCTGCACCTCGAGTTTCCTGCGCAATTTTGAGCAGTCGGTGAACACGCCCTGCTCCAGCCAATATAGCGTCGATGGACGTGATGGCGAGGAGGAGGCTCAGGATGCCTTCACCAATGAGTTCCGCAGAATGAAACTGCGCGGTGAGTTCCCCTGTAAGCTATGCACTGCCGTCTTTCCCAATCTTCGGGCACTCAAGGGCCACAACCGCTACCATCTGTCGGAGGTGGGCGCCGCTGGCCCATTCCGTTGCAACATGTGTCCCTATGCCGTCTGCGACAAGGCGGCGCTCGTGCGTCACATGCGCACTCACAACGGGGATCGGCCCTACGAGTGCGCCGTCTGCAACTATGCGTTCACCACCAAGGCGAACTGTGAGCGCCATTTGCGCAATCGACATGGAAAGACCAGTCGGGATGATGTGAAACGTGCGATTGTCTACCATCCAGCCGAGGATGCCAGCTGCGAGGAGAACAAATCCCGCACCGATGCCGATATCCTAACCGAGCTGAGCGGCTATCGCTGTCCAACACCCACAGAGCACAGTTCCTCGGCTAGCTCCTCGTCCCAACTGAAGCACATGTTGCTGGCGGAGCCGACACCGGCCGTAAaggtaacagcaacagcagcagcaacaacatcgatGCCGCAACAACCGCTCAAGATTCAGGAGGATGAAGAGATGGACTTGGACGATGagtatcagcagcagcagctgccgcacgaggatgatgatgataatgatgatgataatgatgcagcagtcgcagcagcagcagcagaggcgtcgctgcaacaattgcaggCAGCAAAGGACAAACTGCAATCCAAGCCAATTGAGGCCAAAAAGGCAGCGGATATCATAATCAAGGAGAGCGAGGAGAAGGCCTCCGAGAAGCAGGCGCGTTCCCAATCTCAGTCGAGAGGCGGCAATAAGCCGGCGacgccaacaacaatggaaaCAATGATTGCACAAGCGGAATCGGTGGCCAAGTCCTTGAAGGAGGTGGCCAGGTCACCGTTCAAGGATGAATCTCAGGATCTGGTGCCTGTGGCCAAACTGGTGGACAATGCGACCAGCAATCAGGTGTCATTCAATAGCTATTTCCGTCCCAGCGACGTGGCCAATCACATGGAGCAGAGCGACGGGGAGGGTCTCGTCGCCAGCGGCAGCGCCAGCGAGAGCAATAATTGCGGCACCGAGGAtgtgaccagcagcagcagcagctgcggcaacGACACCAAAAAGAAATCCGCCTACAGCCTGGCACCGAATCGTGTCAGCTGCCCGTATTGCCAGCGCATGTTCCCCTGGAGCAGCTCGCTGCGCCGCCACATACTGACGCACACCGGCCAGAAGCCGTTCAAGTGCTCCCATTGCCCGGTGCTGTTCATCACGAAGAGCAACTGCGATCGCCATCTGCTGCGCAAGCATGGCAACGTTGAGTCCGCCATGTCTGTCTATGTGCCCACCGAGGATGTCAGCGAACCGTTACCCATGCCCAAGTCCGTCGAGGAGATTGAGCTCGAGGAGCAGCGACGTCGCCAGGCGGCCGAGGCCGAACAGGCCGAACGGGAGCAGCTCGAGCGGCAAAAGGAGCGCGAACGTGAACTGGAATTGGAACGGGAAAGGGAGcgggaacagcaacaattgatACAACAGTTGCGCCAACAAatggccgctgctgcagcagctgttgctgttgccgttgtcacTGCACCAGCGCATCCACCAGCACCACAGCCAGCCCAATCGCCACCGGGCCTGGAGGCGAGCAGTGATCTGACCTACAAATGCCATCTGTGCGAATTCTCGTTTGGCGAGCGGCTGCAGTGTCTCGAGCACATCAAGCAGCTCCACTCGCACGAATTCGCACTGCTCCTGGCCAAGGGGGCCATAGAGACGGATGCACAACTGCAGCATCAACAGTTGCCAGTGGCTGGTGGCGCCTCGCATTCGGATGATGAGGCTGCCGCTGTCGGCACCAGATCGGGCAAATATCCCGACTATAGCAATCGCAAAGTGATTTGCGCATTTTGCGTGCGTCGCTTCTGGTCAACGGAGGATCTGCGGCGACATATGCGCACCCATTCCGGCGAGCGTCCTTTCCAGTGCGAGATCTGCTTGAGGAAGTTCACATTGAAGCACAGTGGACGCAGTCACAATGGTGGCGAACTCGATCATCAATCTGATTGCTCCGATGATGAGCAGATcaatagcaatagcaagcAGGTGCTGCGCGAGCTGCTGGGCAAGGCAAACGAGTGGCGAGTGAGTCGCCTGGGTGAGCAGAAGGAGAACATTGCCgaggcaacaccaacaccctcagcagcaacagcagcagcggcagcaacagctgcagcagcagcagcagcagcggcagctgtggCCAGTGGCGATCTAATTGGTAATCTGTTGGGGATCAGTGATCAGGGCATTCTAAACAAGCTGCTCTCCTCACCAGACGAAGCTGCCAAGCTGTTAGGAGTGGAGAAGTAA
Protein Sequence
MLATQQQQQQQQQQQSHTAAAAATLEEARDLGLMETRQRRDSSTSESSLEHLDLGRTPKKLSSSSGAPQPTSTPHDTAVTATSRKRKLRQQHQQQQHLPLSDEDQHQQQQQQQQQLLDSSAQRPRHKQRRSAVPAATSASIVVDYSASGDASSLRKKFRLNRSSASSNAANGDLSESGFVDGSALSGYLLGNNNNNNNNNNNNNNNISSSSSSSAVAQSAASAAASAAQHASSVSSSGGSSPQGLSSAESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLNFTTNGNMHRHMRTHKQHQASQQQQQQQHSSQQQQSSQQQQQQQQAQSQSQQQQQRRQQHAGGAGAAGPESGSAQLLTTRAESYESDASCSTDVSSELNSHSSNSNQSNPNNNSHKTNNNNNNKNNNNNNNEDEMELEDEQLVLSSKQRRLKAVLNNNNIIRDEEHENRADDDSDVDSVDSVAQVITSTPDVATLLASGGTSPSHSHSESHSPPLLLQSCPACNSGEFESVPALCAHLDAEHADIPAKCRECEVIFATHRQLQAHSCRGLPPLLGVSSSPLHKQEENELEEEEQQQQQHEEDHEQQHKQEEQEQAEQRECEDFFQQLYLKNKSSAALLPSPIKHEPADQRQDLADIQSILNMTSSSCTSSFLRNFEQSVNTPCSSQYSVDGRDGEEEAQDAFTNEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRYHLSEVGAAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSRDDVKRAIVYHPAEDASCEENKSRTDADILTELSGYRCPTPTEHSSSASSSSQLKHMLLAEPTPAVKVTATAAATTSMPQQPLKIQEDEEMDLDDEYQQQQLPHEDDDDNDDDNDAAVAAAAAEASLQQLQAAKDKLQSKPIEAKKAADIIIKESEEKASEKQARSQSQSRGGNKPATPTTMETMIAQAESVAKSLKEVARSPFKDESQDLVPVAKLVDNATSNQVSFNSYFRPSDVANHMEQSDGEGLVASGSASESNNCGTEDVTSSSSSCGNDTKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPVLFITKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPLPMPKSVEEIELEEQRRRQAAEAEQAEREQLERQKERERELELEREREREQQQLIQQLRQQMAAAAAAVAVAVVTAPAHPPAPQPAQSPPGLEASSDLTYKCHLCEFSFGERLQCLEHIKQLHSHEFALLLAKGAIETDAQLQHQQLPVAGGASHSDDEAAAVGTRSGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCEICLRKFTLKHSGRSHNGGELDHQSDCSDDEQINSNSKQVLRELLGKANEWRVSRLGEQKENIAEATPTPSAATAAAAATAAAAAAAAAAVASGDLIGNLLGISDQGILNKLLSSPDEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-