Basic Information

Insect: Drosophila funebris
Gene Symbol: wek
Assembly: GCA_018901825.1
Location: JAEIFK010000678.1:602350-604234[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0017 0.12 12.8 0.6 1 23 260 283 260 283 0.95

2 8 8e-06 0.00055 20.2 0.6 2 23 294 315 293 315 0.97

3 8 2.7e-05 0.0018 18.5 0.1 3 23 326 347 325 347 0.94

4 8 1 71 4.1 0.6 1 23 353 375 353 375 0.94

5 8 0.00078 0.053 13.9 0.7 1 23 381 403 381 403 0.97

6 8 9.5e-05 0.0064 16.8 0.3 1 23 408 430 408 430 0.98

7 8 3.2e-05 0.0022 18.3 0.1 1 23 436 458 436 458 0.97

8 8 0.0032 0.22 12.0 5.5 1 23 464 487 464 487 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0017	0.12	12.8	0.6	1	23	260	283	260	283	0.95
2	8	8e-06	0.00055	20.2	0.6	2	23	294	315	293	315	0.97
3	8	2.7e-05	0.0018	18.5	0.1	3	23	326	347	325	347	0.94
4	8	1	71	4.1	0.6	1	23	353	375	353	375	0.94
5	8	0.00078	0.053	13.9	0.7	1	23	381	403	381	403	0.97
6	8	9.5e-05	0.0064	16.8	0.3	1	23	408	430	408	430	0.98
7	8	3.2e-05	0.0022	18.3	0.1	1	23	436	458	436	458	0.97
8	8	0.0032	0.22	12.0	5.5	1	23	464	487	464	487	0.98

Sequence Information

Coding Sequence: ATGACGGGTAGCGCAACTGTTAAAAGCAAGGCAGGAGCGTCAATGGAACGCACAGAAACATCAGATTGGCATCATTGGTGCAGGCTGTGTGCCAAAGAACATATTGACAATGTAAATGTGTATTTTAGAGATGGTGATCAAACTTGGACGAGTGTATTGGCTGTGGCCATTGGTAAATACTTCTGGGTCAATATCAAAATGGAAGATGAGCTGAGTAATGCACTCTGTAAGGAATGTTACACCCTGGTGGAGGATCTCATTGAGTTTTCCGATCGTGTGAATCGTGTACAAACTCTTTTCACCAGGCTGCAGGAGGCAGGGTCGCTGGCTGCACAAAGTTACGATGAAATACGGAGGGATTGTGGTCTGCTGACAGATGAAAGAAAGCACATTATATCAAAGAATGTGCCCGTAGAGGCGCCACTTGATGAGTCAGAAGTAGATACATCTGAGTACATCGTCGATGAAGTGGAGTCTTTCGATGAAGATGCTGAGATAATGGCTGAAATTGAAGCCGCAGAAATAATTGAAAACCAAGAAAACGCCTATGAATCGTATGTTGATCATGAAGAGGCCACGGAAGAAGCGTATGTTAAGAACGAAGAATTTATCGAGGAATCAACGGCCTCACTAGAGCCAAAATCTAACTCGGAGCTCGTTGAAAATGATAACTCGATAACTACAAAGGAAGACGACATTAGGGAGACCACAGCAGAAGCCGATCTGAGTGAGAATCAAGTAGCCGAGAACGAAGATGTGTCTAATGAACGTACTCAATATAAATGCATGTCCTGCAGTAAGGGATATAAAAAGCCAATGGCCTATAGAAGGCACATGGCTGAGGTTCATGGCCAGGCTGCGACAGATATTCCCAACCTGGAGTGCAAACGCTGCAATACCGTTTTCGCGACAGAGAATCAGCTTACTGCCCATTATCGCACTCATATGCCTGCCAAGGATAAAGCGGACAATGCATGCAGTTACTGTCCCAAACTATTCACGACAGCTGCAGCTCTCAAGCGCCACATAATGTTCATACATGAGAATGTAAAGCCTTTTATATGTGACTGCTGTGGCAAAGGAATGAAGACAATTACTGCACTCAATGAGCACAAATTGGTGCACACCGATGAATGTCCTTTCGAATGTCCGGTTTGCTATCGACGCTTCAAAAACATGGCCAGGCTGAAGATACACTCTGATACACATACAAATAACAACTACGTTTGCAACATCTGTGGCTTAAAGCTAAACACTCGTCGCACCCTCAATATGCATCAGCTGGTTCATTCGGATGCCAAACAGTTCAAATGCGATGTGTGCGGAGCTGCGTTTAAGCGAGGTAAAACATTAAAGGCCCATCTGATACTTCATACGGGTATAAGGCCTTACAAGTGCAATTTTTGCGGAAAGGACTTTTCGAATGGTTCCAATTGTCGCATGCACAAACGTAAAACGCACCCCAAGGAGCTGGCAGAGGAAGAAGCACGTGGCGTAATGCGTTCAACTCTGCTTCCCATGATTACTGAACTGACCGAAGCATCCAAACGGGTCAAAAAGCCAGCCAAAACAGGAACGTCGTTGGTTCGAACAAAGGTCACGGAAGAGAGTTTTCAATCTTCAGATACCAATATTGTGGTTGAAGACATGGAGGCGGAAGTTGATGATGAAGTGCTCTACGAGATTGTCGAAGAGTGCCCATAA
Protein Sequence: MTGSATVKSKAGASMERTETSDWHHWCRLCAKEHIDNVNVYFRDGDQTWTSVLAVAIGKYFWVNIKMEDELSNALCKECYTLVEDLIEFSDRVNRVQTLFTRLQEAGSLAAQSYDEIRRDCGLLTDERKHIISKNVPVEAPLDESEVDTSEYIVDEVESFDEDAEIMAEIEAAEIIENQENAYESYVDHEEATEEAYVKNEEFIEESTASLEPKSNSELVENDNSITTKEDDIRETTAEADLSENQVAENEDVSNERTQYKCMSCSKGYKKPMAYRRHMAEVHGQAATDIPNLECKRCNTVFATENQLTAHYRTHMPAKDKADNACSYCPKLFTTAAALKRHIMFIHENVKPFICDCCGKGMKTITALNEHKLVHTDECPFECPVCYRRFKNMARLKIHSDTHTNNNYVCNICGLKLNTRRTLNMHQLVHSDAKQFKCDVCGAAFKRGKTLKAHLILHTGIRPYKCNFCGKDFSNGSNCRMHKRKTHPKELAEEEARGVMRSTLLPMITELTEASKRVKKPAKTGTSLVRTKVTEESFQSSDTNIVVEDMEAEVDDEVLYEIVEECP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00558143;
90% Identity: iTF_00537731;
80% Identity: -