Dfun011171.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila funebris
Gene Symbol
zfh1
Assembly
GCA_018901825.1
Location
JAEIFK010000678.1:1437572-1441927[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.7e-05 0.0018 18.5 1.0 1 23 149 171 149 171 0.97
2 15 0.00082 0.056 13.8 1.2 3 23 179 199 177 199 0.94
3 15 8.9e-05 0.006 16.9 0.1 1 23 355 377 355 377 0.98
4 15 0.00069 0.047 14.1 0.8 1 23 383 405 383 405 0.98
5 15 3.4e-05 0.0023 18.2 2.2 1 23 436 459 436 459 0.95
6 15 0.00059 0.04 14.3 1.9 1 23 500 522 500 522 0.95
7 15 0.0024 0.16 12.4 0.4 1 23 528 551 528 551 0.98
8 15 0.026 1.8 9.1 0.4 3 19 560 576 559 577 0.95
9 15 0.00015 0.011 16.1 5.6 1 23 586 608 586 608 0.97
10 15 0.04 2.7 8.5 1.2 2 23 614 635 613 635 0.96
11 15 9.1e-06 0.00062 20.0 1.0 1 23 644 666 644 666 0.98
12 15 0.001 0.07 13.5 0.1 3 23 674 694 672 694 0.97
13 15 5.5e-05 0.0037 17.5 0.5 1 23 700 722 700 723 0.95
14 15 0.051 3.4 8.2 0.4 1 23 733 755 733 755 0.97
15 15 0.0029 0.2 12.1 0.1 1 23 1297 1319 1297 1319 0.97

Sequence Information

Coding Sequence
ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCAGTCGACTCCGAGTCAGATATGCTGGAAAACGGCGCTGCCGACAGTGAGGTGACTGCGTCCTATTTGGTGAATGGCAATGCTACCGACGAGGATCTCGACCATATGGCGGCCGAGAATCTCATCTTTATGGCTCGAGACGGTCAGCTGAGCGAGATAATAGCCGCCAACGAATCGGGTGGCGGCACAGTCCTAATCACTGACAGTGGCGTTGCATATGCCGAGTCATTCGATGATGACGCACAGGTGGTCACCGAGGAGATCATTACTGATGATTGGGTGCAGCACCAAGGCGCCGAACGTGTCGAAATCGCTGCGGAGCAAATTGCAGGCAATGCCAATTCGCTGGAGCTACTGGATATGGAGCAGGATGAGTATACGGCACTGCGACCCTATCCTTGTGATTTCTGTAGCCGGCGTTTTCGCAAGAAGGCAAGCCTCAATAACCATATGCTGGCGCATCAAAACGATCGTCCGCATCTGTGTAAACTGTGCGGTGCACGATTCTCACGTCGTGCCGAGCTCATCAGTCACTTTAAGGCCCATGCGGAGGCTCAGGATGCAGCCGATGCTGAAGCCGCAGCGGCAGCGTCAGCGTCAATTAAATTTGAGCCACAGCAACACAGGCAAGTGGATGATCATTTCTACGAACAGGAGTGGCCACTGTATCAGGACCAAGAACACGAGCACATGCAGGAGCAGGGACAACAACTGGACCAGGAGCAGTTAACCGTCGCCAGTCAAGTGGTGCAACAGGCCAGCTATGCCTCAGTAAGCGATGTGCCACCGCCAACAGCTGCCCGCGGTCGCATCAGCCGGCTGAAGCCCAAGGAGGAGAGCACGCAGTATATTGTGATTGCTGAGAAGCAGACAACCGAGGAACTGCAACAGTTTGTGGACTGTGAGGAGCTAACGCCACAGCTGACCACCTGTGCAACATCTAACAATTCTATGGACACCGGTCAGAGCATGGATGCATCACGTTACCCAGTGCTGGATGACAGTAAACCCTTTGTATGCCAACAATGTGGCTTGGCATTTGCACGGGAGAAGGCGCTAGTGTCGCATATCAAGAATCATCGCGTGGACTCGCCGTTTGAATGCAATCAGTGCCAGGAGATGTTCTGGGATAATCAGAGTCTGCAGGAGCACCAGAAGACGCATCAGTTCGAGGAGAGCAATTCAGAGTATGATCCCGCCTCGGCGGGAGATGACAGTGCCAGTGAATCGGAGCCAGATCAGCTCTATGGTGACTTCTACTGCAGTGAGTGTGGCATTTCATTTCACAGACAGGACCTGCTCCGTCGCCATGCCAAGCAGCAGCACAAGCTGTCCGTGGCAACAACACTCCACGCTGCCGATGTGGAGGGCAGTGCAGATGCTGATGCTGATGGTGATGGCGATGGGGATGGGGATGGCGATGCGGAGAATACCAAAGATGCGCCACACTGTTGTCACACATGTGGCAAATCGTTTCCCAGCGCACTCGAGCTGCTTGCCCATGCCGAGATTCATGCACGTTTCCCGCCATTCAAATGCGTCTTGTGTGGCATTAGCTTTTACGAGGAACAGGCCATTAAAAGGCATTTGAACACCCGTCATCCGCACGAGCTGAAACCAAATTCATGTGTTCTCTGTGGCAAGGAATGCCGCGATCGCAAGGCGTTGATCAAACACGCCTGGGATCATTCGCGCGAGAAGTGCCACTCGTGCTCCAAGTGTGGCAAGAACTTTCACAACAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGTGACAAGTCCGTGGTGTGCGAGGTCTGCCACGAGGAGTTCCCCGATGGCCGCACCCTTTCCAATCATCGTCATTCGCATAGCACCACCTCGCCGGGTAAACTGTTCCCCTGCCACGAGTGCGGCAAGACCTTTGGCTCCCGCAGCTCACAGCAGATTCATGTGCGTATCCATACGGGCGAACGGCCATATGGTTGTCGCTATTGCTGGAAGGCGTTTGCCGATGGCGGCACACTGCGCAAGCACGAAAGGATTCACACCGGCGAGAAGCCATATGCCTGCTCCGTTTGTCCGCGTGCGTTCAATCAGCGTGTCGTGCTGCGCGAGCACATACGCTCCCATCATTCGGGCTTGGATGCGGTGCGTGGCACGTATCATTGCACCGTCTGCACGGCGGACTTGTCGTCATCCAATGAGCTGATACAGCATCTCATACAACACAGCGACACGAACACAGCCAAGCAACGACAACCAATTACTGGACCACGCAAGTACAAGCGACGAAGGAAGCTGCAGCCCCATGAGATTGCACATATGCGGGCTGAGAACAAGGATGCTGACGATTATGGCAGCGACATGGATCTCTGCGATTTGGATGTGGAAAATGTGGACGATCTCTTTGATGCGGCAGAGCCAACGCCACCCAAAAGGGAAAAGCGCAAACGGAATGCCGCAAGTCAAGCGAAGCCTGGGGCAAATTGTGTCTCAACCGGCGCCCTAAACAACAACACAACTTCAGCAGGGAAGTCTGCGAATGGGAGTCAGGATCGCATGTGGGAGGAGAAGTTCCTGCAGGCCAATGGCAATGGCAATGGCAATGGCAATGCGGGCAATCAGCTGAACGACTTTTTTCAAATTGATTCACTGGTGGTGGTAAATGATACCACGCTGCAGCCTGTTAGCTCATCCAGTGGTGGCACAGTAGCCAAGACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATGAGTGTAGCAAGTCCAATGCCTCTGTTAGCTCAAACAGTCGGAGCAGCCGTAAGAAACCTGGCAAGTCGTCCAAGAACTCAAGCACAACGGCATCCACATCGAGCAGCACACGTCCACGCATGATACACACGGAAAAGTCACGTTTGCCGCTAGACAGTGGAACGAAGAAGACGCGCGGCAGATCCTATGTGACCAGGACGAGCACCAGCGAGAGCAGCCAGCTGGGACTGGTCAAGTCGAGTGGCGTTGCCAGTTCGCGCATTGTGGATGACTATGAGATTATATCACCTGCCACACAGCCACCAAATCAGATAAGCTCCAGTCCGCTGCACATTAAGCAGGAACAGGAGCAGCAGCAACAGCGGGTCCCCCTCATGTTTGATGAGACGCATCTGCTGATCGATGCGGCGCTGTTGCGTGAGAAGACCTACGAGAAGTTCAATCCCAGCATTGTCAATGATCTCGAGGAGATATTGCGTAGTCCCCTCAAGCATGATCGCAATGCTCGATTGCGTTTCACCAGCGAATCATCGACAACGCCACAGTTTCTGCCCGAGGAGGAGCAGAATCTTATCAAGATTGAGCCAACGTCGCCGGATTTGCGTGAAATGGTTGAGAGTCAGCAGCGTGTGAGTTCCACAGGACATANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTGCCGTTAGCAAAGCCAACTCATACCTCAGCTACGGCGTCGACGCCTACAATGTGAATGTGACCAACAATGCCAACTCATCGGATGTCAGCTCAGGTTTCTTTTCCATCTCCGAAGTCGTATCCGCCGCTGATGCCGCCGATGCAGCCGCCAAGGCGGCAGCGGCCAACAAAACCGAGCGTCGAGCCCGCTGCTATGAGTGTGAGATGTGTTCGGCCAATTTTCCGGATCGGGCGCAGTTGTTGGAGCATGTGCACATACACATCTGA
Protein Sequence
MNNQDYGGIQWIQQHASAVDSESDMLENGAADSEVTASYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDSGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANSLELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAASASIKFEPQQHRQVDDHFYEQEWPLYQDQEHEHMQEQGQQLDQEQLTVASQVVQQASYASVSDVPPPTAARGRISRLKPKEESTQYIVIAEKQTTEELQQFVDCEELTPQLTTCATSNNSMDTGQSMDASRYPVLDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNQSLQEHQKTHQFEESNSEYDPASAGDDSASESEPDQLYGDFYCSECGISFHRQDLLRRHAKQQHKLSVATTLHAADVEGSADADADGDGDGDGDGDAENTKDAPHCCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLNTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDAVRGTYHCTVCTADLSSSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHMRAENKDADDYGSDMDLCDLDVENVDDLFDAAEPTPPKREKRKRNAASQAKPGANCVSTGALNNNTTSAGKSANGSQDRMWEEKFLQANGNGNGNGNAGNQLNDFFQIDSLVVVNDTTLQPVSSSSGGTVAKTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXECSKSNASVSSNSRSSRKKPGKSSKNSSTTASTSSSTRPRMIHTEKSRLPLDSGTKKTRGRSYVTRTSTSESSQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKQEQEQQQQRVPLMFDETHLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSSTGHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAVSKANSYLSYGVDAYNVNVTNNANSSDVSSGFFSISEVVSAADAADAAAKAAAANKTERRARCYECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00579414;
90% Identity
-
80% Identity
-