Basic Information

Insect: Drosophila flavopinicola
Gene Symbol: THAP1
Assembly: GCA_035042425.1
Location: JAWNLL010000476.1:1760967-1763261[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.041 2.6 8.7 1.7 1 23 392 415 392 415 0.92

2 7 0.031 1.9 9.1 0.9 2 23 520 543 519 543 0.91

3 7 0.043 2.7 8.7 0.5 2 21 555 574 554 575 0.95

4 7 1.1 67 4.2 3.0 1 20 590 610 590 612 0.93

5 7 5.8e-05 0.0036 17.7 1.9 1 23 653 675 653 675 0.97

6 7 7.9e-06 0.00049 20.4 1.0 1 23 681 704 681 704 0.96

7 7 2.8 1.7e+02 3.0 0.5 1 13 710 722 710 727 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.041	2.6	8.7	1.7	1	23	392	415	392	415	0.92
2	7	0.031	1.9	9.1	0.9	2	23	520	543	519	543	0.91
3	7	0.043	2.7	8.7	0.5	2	21	555	574	554	575	0.95
4	7	1.1	67	4.2	3.0	1	20	590	610	590	612	0.93
5	7	5.8e-05	0.0036	17.7	1.9	1	23	653	675	653	675	0.97
6	7	7.9e-06	0.00049	20.4	1.0	1	23	681	704	681	704	0.96
7	7	2.8	1.7e+02	3.0	0.5	1	13	710	722	710	727	0.79

Sequence Information

Coding Sequence: ATGCCCGCCCACTGCGCGGTGGTCAATTGCAGcgacaaatatgtacattccGGCAGCATATCCTTTCACAGATTTCCATTCAAACGCAAGGATTTGCTGCAGAAATGGAAGGACTTCACACAGCGCAGTGGCCAATGGATGCCCTCCAAATGGAGCGCTGTCTGCAGTCGTCATTTTACCGACTCCGACTTCAACTGCAGCAATAATCGGAAAACTCTCAAAAAGAATGCGTTGCCCACGGTGCGAATGCCGGCGGAATCGCTGAATGTCATTGTGGAGCAGGTGACGCTTCCGCCGCCAGCAACTGAAACGCCGgcgagcaactgcagcaatggCGCCAAGAGCACCTGTCGTTTCTGTGGCACAACTGCTCTAAATTGCGTATCCTTCGACAAGAGCTTCGAGCTGTTTGGCATGATTCAGAAATGCTTTCCCACGCTTCAAATCCTGCAGGACGACACACTGCCGCTGCCCAAGGACATCTGCGGGGAGTGCTGCCGCCAGCTGGAGCGCTTTTCTCAATTCTGTGATGTCGTGATGCTCGCCCAGAGCGAATTGCAGCGCAAATATCGCCGCCAGCTGAAGATCAAACAGGAGCCGGTGGTGCGCGTGAAGCAGGAGGCGTGCGAAAGCCTGGACAATCTGTTTCCGGATGAGCTGGACATGGGCCTGGACGAGGGCTGCTGCGACCACGAGCCGGAGGCGCCGGATGAAACGGAGCACAAGTTTCAATTCTGCGATTTTCCCATGCTCAATGCGCAGGACATCATCGATAACTGTGATATAATGGAGATAATCAATCTGGATGACCCGTTCATAAACATAACAGACGATGCAGATGTGGCGCAGGCGAAGGTGCAACAGCCGGTCTCGATGCCTGTGCTGCCCAGCGCACAGGACCTGCTGCAAACGGAGCTGCTCACCGAGGAGCACAACTATGCCAAGGAGGAgtggcagctgccgccgctgcaaCAGTACAAAACAGAGAAGGTGGAGGGCATTGAGCTCGACTCGGCTCCAACTGAGCCACGCAGCTGCAAGCCGATCGTCACGAATGTCAGCCAGATACCCAATCCCCTGATCTGCGAATTgttgccaccaccaccaccgccggtCAAGCCCAATATTGTGGTGCTCAACGACAGCGTGGTGCAATCGTCCGCCTTTCGCCTGCACAACTGTAGCCTGTGCAGCAATAAGTTCTTCACCGCCGAGAGCCTGCAGCAGCACTATGCCCAGgcacatgccacgcccacgcccactcccactcccatgCCCATGGTCAGTGTGCCGTCGCCCAAGCTGGAGGCCAgctcgctgccgctgccgcccgCTGTTGACTACTGGCAGGCCGACTGGCTGCCTGCTGCGCCGCTGCCTGCCAAGAAGAAGATCGATATTCTGGACATGCAGCGCAGCTTTCTGCATTGCAACGATCTGATTGCGGTCAGCACCCCGGACGCAGCCAATGCCAAGCTAGCCGCACGCTTTCGACGCCTGCAGCACAAGTGTCGTCGGCTGCAGCAGACTGGCAAGCCCGGCTCAAATCCACGCCTGCGTTGCGGTCGCTGCTCGCGAGCATTTGCCAGcgtgcagcagttgctgctgcaccgGAGACGCAAGCGACACTTTGTGCTGCCGCCGCCCCGGACCTTTGCCGTCAAGTGCTTCGGCTGCCTGCGACTGTTCCGCTCGCGTCTGGGCCTGCGTCAGCACATGCGCTACatctgccagctgctgccgctgcgcaaTGCCCGCCTGCAGAGGTACAAGTGCCGGCACTGTCAGAGCATCAGCTTCACCCACTGGCGCGTCTACAGGCGGCACGAGCTCAAGTGTCgcctgcggcagcagcagcagcagcacaagacGCTGTCGGTTCGGAGACGCCGCCGCGTAGCTGCTGGTCacgcacaggcacaggcacaggaaCAGGCACACACGAAAAGGACCGGCCACAGCTGCGCTGTCTGCCAGAAGAGCTTCAGCTCCCTGACTGGCCTCAAGCAGCACCGCATCACGCACAGTTCGGAGCGACGCTACAAGTGCAGCATCTGTGAGCGCGTCTTCAAGCGGCGCAACGGTCTCTCCCAGCACATCAAGGGCTATCATCTGCAGTTGAAGCCGCATCAGTGTCCGGTCTGCCAGCATCGATATGCCCTCAAGTGCGACATGATGCGCTGCCGGCACTCGCAGCGACGCGGCCCCAATGCCAGCGATAATCCCGAGCCAGCGAAGGCCTAA
Protein Sequence: MPAHCAVVNCSDKYVHSGSISFHRFPFKRKDLLQKWKDFTQRSGQWMPSKWSAVCSRHFTDSDFNCSNNRKTLKKNALPTVRMPAESLNVIVEQVTLPPPATETPASNCSNGAKSTCRFCGTTALNCVSFDKSFELFGMIQKCFPTLQILQDDTLPLPKDICGECCRQLERFSQFCDVVMLAQSELQRKYRRQLKIKQEPVVRVKQEACESLDNLFPDELDMGLDEGCCDHEPEAPDETEHKFQFCDFPMLNAQDIIDNCDIMEIINLDDPFINITDDADVAQAKVQQPVSMPVLPSAQDLLQTELLTEEHNYAKEEWQLPPLQQYKTEKVEGIELDSAPTEPRSCKPIVTNVSQIPNPLICELLPPPPPPVKPNIVVLNDSVVQSSAFRLHNCSLCSNKFFTAESLQQHYAQAHATPTPTPTPMPMVSVPSPKLEASSLPLPPAVDYWQADWLPAAPLPAKKKIDILDMQRSFLHCNDLIAVSTPDAANAKLAARFRRLQHKCRRLQQTGKPGSNPRLRCGRCSRAFASVQQLLLHRRRKRHFVLPPPRTFAVKCFGCLRLFRSRLGLRQHMRYICQLLPLRNARLQRYKCRHCQSISFTHWRVYRRHELKCRLRQQQQQHKTLSVRRRRRVAAGHAQAQAQEQAHTKRTGHSCAVCQKSFSSLTGLKQHRITHSSERRYKCSICERVFKRRNGLSQHIKGYHLQLKPHQCPVCQHRYALKCDMMRCRHSQRRGPNASDNPEPAKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00508368; iTF_00538263; iTF_00538581;
90% Identity: iTF_00508368;
80% Identity: iTF_00508368;