Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3 1.2e+04 -4.0 1.3 72 72 73 73 45 90 0.55

2 2 3.7e-50 1.5e-46 157.3 0.1 4 92 116 204 113 209 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3	1.2e+04	-4.0	1.3	72	72	73	73	45	90	0.55
2	2	3.7e-50	1.5e-46	157.3	0.1	4	92	116	204	113	209	0.97

Coding Sequence: atGCACATTTCAGCTGAGGTAAGTTCGACCACCTCAAACCaaacacagcaacagcaacagcaacagcagcatcagcagcagcaacatcaacagcagcagcaacaacaacaacaacaggcgacacagcagcaacatacaacggcaacggcaacaacaacaataacaacaacgggCAGCACAACGAAGCGACGCAATGCAgagagcaataacaacaacagcaataccaacaacaacaacactagcagcaataacaacaacaatagcaatagcaatacGAAAAGCAAACCCGTGGATACAAGTCCATATTTGACACCAGAAAATCTGATCGAGCGCACCGTCGATGTCCTGTTAGCGGAGCATCCCGGTGAGCTTGTAAAAACTGGCTCTCCCCATGTGGTCTGTACCACACTGCCCACCCATTGGCGCTCGAATAAGACGCTGCCCATTGCCTTTAAAGTGCTGGCTCTGGGCGAGGTCATGGATGGCACCATTGTCACCATACGAGCTGGCAACGATGAGAATTTTTGTGGTGAACTACGCAACTGCACCGCCGTCATGAAGAACCAGGTGGCCAAGTTCAATGATCTTCGGTTTGTCGGACGCAGCGGCAGAGTTGTCAAGGCTGCAGACGCCGAATGTCCCTTGGCATGCTACGATTTATGGTTGTGCAGCATGCGCTTCAATGGAGTTTCAAGCACACTGCGACGGCTGCTCTAA
Protein Sequence: MHISAEVSSTTSNQTQQQQQQQQHQQQQHQQQQQQQQQQATQQQHTTATATTTITTTGSTTKRRNAESNNNNSNTNNNNTSSNNNNNSNSNTKSKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRVVKAADAECPLACYDLWLCSMRFNGVSSTLRRLL

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00601539; iTF_00528574; iTF_00516769; iTF_00513235; iTF_00518934; iTF_00610422; iTF_00556990;
90% Identity: iTF_00512495;
80% Identity: -