Basic Information

Insect: Drosophila eugracilis
Gene Symbol: zfh1
Assembly: GCA_018153835.1
Location: NW:183055-206497[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00086 0.054 13.6 2.0 2 23 75 97 74 97 0.95

2 9 0.0012 0.076 13.2 0.2 1 23 279 301 279 301 0.96

3 9 8.8e-05 0.0056 16.7 1.7 2 23 315 336 314 336 0.97

4 9 4.3e-06 0.00027 20.9 6.3 1 23 345 367 345 367 0.99

5 9 0.00026 0.016 15.3 1.2 3 21 375 393 373 394 0.94

6 9 0.0059 0.38 11.0 0.7 2 21 619 638 618 639 0.92

7 9 2.9e-05 0.0019 18.2 0.5 1 23 953 975 953 975 0.95

8 9 4.3e-05 0.0027 17.7 7.4 1 23 981 1003 981 1003 0.98

9 9 0.0021 0.14 12.4 4.3 1 21 1009 1029 1009 1030 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00086	0.054	13.6	2.0	2	23	75	97	74	97	0.95
2	9	0.0012	0.076	13.2	0.2	1	23	279	301	279	301	0.96
3	9	8.8e-05	0.0056	16.7	1.7	2	23	315	336	314	336	0.97
4	9	4.3e-06	0.00027	20.9	6.3	1	23	345	367	345	367	0.99
5	9	0.00026	0.016	15.3	1.2	3	21	375	393	373	394	0.94
6	9	0.0059	0.38	11.0	0.7	2	21	619	638	618	639	0.92
7	9	2.9e-05	0.0019	18.2	0.5	1	23	953	975	953	975	0.95
8	9	4.3e-05	0.0027	17.7	7.4	1	23	981	1003	981	1003	0.98
9	9	0.0021	0.14	12.4	4.3	1	21	1009	1029	1009	1030	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCGTCGTCTTCACGTTTCGGCCAAGAGGATACCATCATTCAGCAGAGCATGCCCTCCACCAACGCCTTCACCATGCAGTTTCCCTCGCTGGCCGCCACTTTGCTCCACCACAACCAGTCGCCGAAGCACAGCAACGCGGGACCCACTGGGATCCAGGACGCCCACCCCAACCAGCCAGGTGCAGCTGCAGATGCCTTCTTGGTCAAGTGCACCCAGTGCCACAAGCGCTTCACAGAGTTTCAGTCCCTCACCGAACACATTGCCAGCGAGCACCCCCACGACAAGCTGAACTGCGGAGCTGCCCAGCCGGAAAGCGATGCCGAAGACGAGCAGAGCAACATGAGCGGCAGCAGTAGACGGTTCACCAAGTCGCCGgtcaccagcagcagcaacaaccagtccagcagcaacatcaacaacaacaacagtgaGCTGGCCAAGAACCAGAACAGCACCAACAAGATGTCACCAATGTGCTCACCTGGATCGCTGAGCCACAGCGACCTGTTCGCCCAGCTGCATCACCCACCGCCCCAGTTGCCACCCCACCTGCACGCCCAGTTCatggccgccgccgcctccttCGCCATGCAAACCGCCCGATCCGCCAGTTCGCccagccagcagcaacagcagcagcagcagcagcagttgcaacagcagcatcagcagcagctggcCATGCAGCAACTGCTGCCACCCCAACTGcccggcagcaacagcagcgtgGGCAGCAATTCCGCCTACGACCTGGATCTCAGTGCCCCGCGGTCCACCTCGAGTCCGGGCTCCACCACCGGGGATCTGAGCGGCGCCTATCCCTGCATGCAGTGCACCGCCTCCTTCGCCAGTCGCGAGCAACTCGAGCAGCACGAGCAACTCCACTTGCCCTGCGGCCAGACGGCGGGCACCAGTGTCTCTCAGACCTGCCGGATTTGCCACAAGGCCTTCGCGAATGTGTACCGCCTGCAGAGGCACATGATCAGTCACGACGAAAGTGCGCTCCTGCGAAAATTTAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTGAAGGAGCACGTGAGGATCCACTCGGGAGAGAAGCCCTTTGGATGCGACAATTGCGGCAAGAGGTTCTCGCACTCGGGCAGTTTCTCCTCGCACATGACTTCAAAGAAGTGCATCAGCATGGGTCTGAAGTTGAACAACAATCGTGCTTTACTGAAGAGACTGGACAAGAGTCCTGGTTCTGGATCTTCGGGATCCCGTCGATCGCCTTCTGATCACGGAAATGCAAAGCTGCCAGAGCAGCCAACTCTTCCCGGGTTACCCAATCCCATGATATATTTCGCCAGCGATGCCCAGAACCAAGGTGGAAATGCGGCACCTACGCCCTTCCCACCTTTCCACCCCACGAACTACATGAACGCCGCCCTTTTGGCCTTCCCTCATAACTTTATGGCAGCCGCTGCAGCTAGCCTGGATCCTCGGGTTCATCCCTACAGCATCCAAAGACTGCTGCAACTTTCCGCTGCAGGTCAGCAGCAAAGGGAGGAGGAACGggagcagcaaaagcagcggcaggaagaggaggagcCTGCCGATGAACCAAAATTGGTGATGGACATCGAAGAGCCGGAGGCCGCGGAAAGAGTGTCTACACCGGAAGCCACAGTAGAAGTTACTCCCATCAAGCAAGAGGAAAGCAGGGAAGCTTCTCCCGCTCCAGAGGGATATCTTTCATCCCCTCAAGCCATTAAACAGGAGCAAGAACCCCTTAACGTGGCAGAAGAACCTCAAATCTCGATGGAGGAACCGGCTCAGCCAGAGCCAGCAGCCGATCTGCGTTGCAGTCGCTGCTCCAAACAGTTCAATCATCCCACAGAGCTCGTACAACATGAAAAGGTTCTTTGTGGTTTGATCAAGGAGGAGTTGGAGCAACActtccagcagcaacaggctgCAACCTTCGCTTTGCCCTCCGCCAGCGAAGAGGACGAGGATGATGAAGAGATAGAGGAGGAACCCAGGCAGGAAAGTGGCGAACGGAAAGTCCGAGTGCGAACGGCTATTAACgaggaacagcagcagcagttgaaGCAGCACTACTCCCTGAATTCCCGACCCAGTCGAGAGGAGTTCCGCATGATAGCAGCCCGTCTGCAGTTGGATCCTCGAGTGGTTCAAGTCTGGTTCCAGAACAACCGCTCCAGGGAACGCAAAATGCAAAGCTTCCAGAGCAATCAAGGCACCGCACCAACGGTGACCAATGAATCTCAGGCTCCACTAACCCGAGAAGATCAACCTCTGGATTTGTCAATAAAGAGAGATCCCCTCACACCCAAAAGTGAGAGCTCGCCTCCTTATATAGCTCCTCCATCGGGAGAGCCCTTAAATCCCGAGGCCATCAATCTCAGCAGGAAGTTTTCCACATCAGCATCGATGTCACCAGCTTCGATTTCACCGTCATCCGCGGCAGCCTTATACTTTGCAGCTGCCCCGCCGCCTTCGCCACCAAATAGTCAAATGGATGCCACTCCTCGAAGTGGTCAGGCCTTCCCGGGACTACCCCCCTACATGCTGCCTATGCCGTTGCCCATGGAGGCGCTGTTTAAGATGCGCCCGGGTGGGGAGTACGCTCCCAATCATCCCCTGATGAACAGTATTAAGCTGCACGATTACCGAGGCACTAGTCTGAGCCCCGGTGGATCGGAGAAGCGTTCGTGGCGGGACGACGACTCGCGTATCTCGCATGAGGATGAGTTTGGAGGCGGTGTCTTGATGCCACCGAAACCCAAGAGGGGCAAGGCGGAGACCCACGGACACGCGGGTGATCCCGATTTGCCCTACGTGTGCGATCAGTGCGAAAAGGCCTTCGCCAAGCAAAGTTCGCTGGCACGACACAAATACGAGCATTCCGGTCAAAGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTCACGGAGCACAAGCGTCTGCACAGCGGTGAGAAGCCCTTTCAGTGCTCCAAGTGCCTGAAGCGATTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGGTATTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDTIIQQSMPSTNAFTMQFPSLAATLLHHNQSPKHSNAGPTGIQDAHPNQPGAAADAFLVKCTQCHKRFTEFQSLTEHIASEHPHDKLNCGAAQPESDAEDEQSNMSGSSRRFTKSPVTSSSNNQSSSNINNNNSELAKNQNSTNKMSPMCSPGSLSHSDLFAQLHHPPPQLPPHLHAQFMAAAASFAMQTARSASSPSQQQQQQQQQQLQQQHQQQLAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLEQHEQLHLPCGQTAGTSVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLDKSPGSGSSGSRRSPSDHGNAKLPEQPTLPGLPNPMIYFASDAQNQGGNAAPTPFPPFHPTNYMNAALLAFPHNFMAAAAASLDPRVHPYSIQRLLQLSAAGQQQREEEREQQKQRQEEEEPADEPKLVMDIEEPEAAERVSTPEATVEVTPIKQEESREASPAPEGYLSSPQAIKQEQEPLNVAEEPQISMEEPAQPEPAADLRCSRCSKQFNHPTELVQHEKVLCGLIKEELEQHFQQQQAATFALPSASEEDEDDEEIEEEPRQESGERKVRVRTAINEEQQQQLKQHYSLNSRPSREEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSFQSNQGTAPTVTNESQAPLTREDQPLDLSIKRDPLTPKSESSPPYIAPPSGEPLNPEAINLSRKFSTSASMSPASISPSSAAALYFAAAPPPSPPNSQMDATPRSGQAFPGLPPYMLPMPLPMEALFKMRPGGEYAPNHPLMNSIKLHDYRGTSLSPGGSEKRSWRDDDSRISHEDEFGGGVLMPPKPKRGKAETHGHAGDPDLPYVCDQCEKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00588330;
90% Identity: iTF_00581434;
80% Identity: iTF_00505308;