Basic Information

Gene Symbol
ush
Assembly
GCA_018150545.1
Location
JAECWL010000189.1:6449936-6454597[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.045 3.1 8.2 0.0 1 20 246 265 246 267 0.89
2 9 0.00029 0.021 15.1 0.7 1 23 322 344 322 344 0.98
3 9 0.047 3.3 8.2 1.0 2 21 388 407 388 408 0.92
4 9 0.045 3.2 8.2 2.9 2 21 818 837 817 838 0.93
5 9 0.0084 0.58 10.5 0.0 3 21 891 909 889 910 0.91
6 9 0.006 0.42 11.0 0.0 2 23 978 999 977 999 0.98
7 9 0.0035 0.25 11.7 1.3 1 23 1005 1027 1005 1027 0.99
8 9 0.0013 0.089 13.1 0.9 1 23 1076 1099 1076 1099 0.96
9 9 0.24 17 5.9 0.3 2 20 1216 1234 1215 1236 0.91

Sequence Information

Coding Sequence
ATGTCGAAATTCTGGCGAAGCGAGATGCAAACTGCAAGCTGCGCCTGCTCTCTTATCCTGCAGCTCCATCTCCATGCCATGTCCATGTCCATGTCCACGTCCACTGGCTTGTCCAGGGAACTTTCCGCACTGTCTGTCCGCCGCCATAATCTCGGCCAGCATCGCCGCACTGATTCCAAAGATTTAACCGCACAGGAGCTGGGCGAGGAGAAGCAGCTCCATCAGCTGGAAGATCAGCTATCAGATCAGATGGACGACTCCACTGATAACCACGAAAATATTAACAATAACAATAATGACGCGGAGGAGGACACGGTGTCCGACCAGCCGGAAGAGACTAATGCCGAGGATTTGATGGAAACTGAGATGATGGATCAGGATCACGAGCCCCAGCCGGCCGCGGAGGAGGACGGACTTGACCTGCCTCGCAATAGTCCCAGCACACCACCAAGAAGCCCCATCGGATCTCCACGGTTGATTCCAAAGCTGGAGCAGCCTTGTACGCCACCCTCAGAGCCCGAGGCCGAGGCGGAACCATCGCCGTGTCCCTCCCCATCTCCCATTGCTCCCAAGTTGCCCAAACTGCGGTTGAACGCCCTCCTGGCCTCTGATCCTGCCCTCAAGCCGGATGCCAAGGAGCTGAATCTGTCGGAGCCACGTCTGCTGGCTCCTCCGCCGCTGATCAAACCGGAGGTGCAGCCGGAGATCGTGGAGCCTCTCCTGAAACCGGCCCGGTTCATGTGTCTGCCCTGCAGCATTGCCTTCAGTTCGCCCTCAACGCTGGAGGCCCATCAGGCCTACTACTGTTCGCACCGGAACAAGGACACGGAGGAGGACCAAGGAGCGGGCACTGGCGACAAATCGGCAGGCGGCGTTGGCGGAGCATCCTCGGGAGCGGCTGGATCCGGCTCGGGAAGTGGTTCCTCGGAACCACCGGCAAAAATGGCCAGGACTGGCAAGCAGTACGCCTGCTCCCAGTGCTCCTACAGCGCCGACAAGAAGGTGTCCCTCAACCGACACATGCGAATGCATCAGACATCGCCGGCTACTCCCAGTCTGGTGGTGGCCAGTTTGCCGAATCTCGTCCAGAACGGCTTGCCATCGACAGGAGTGCCGGCGAATTCCCTCGAGGAGAGCCCTAGTCAACAGCAAACGGATCGCTATTGCAGCGACTGTGATATCCGGTTCAATAATATAAAAACCTATCGGGCTCACAAGCAGCACTACTGCAGTTCCCGCCGGACAGAAGGTCAGCTGACACCCAAGCCGGATGCATCGCCCGGCGCCGGCGGAGGATCGAGTGCATCGGCATCGGTTGCCTCGGCCGTGGGAGTGTCTGTCCAGGGAACAGCTCCCGGCAAGCTGAGTCCCCAGACCCGGAACAAGACACCCACGCCGGCCATGGTGGCTGCAGCGGCGGCGGCGGCAGCAGCAGCAGCGGCGGCAGCTGCCTCGTTGCAAGCCCCACCACCCCAACCGTTCCTGGCTCTGCCCACACACCCCATCATCATTGTGCCCTGCTCCCTGATCCGGGCAGCCAGCATCATTCCAGGGCCATTGCCCACACCCTCGTCGGGAATTGTGAATCCGGAATCCACCTGCTTTACAGTGGAGAATGGCACCATCAAGCCTTTGGCCACCGCCTTGCTGGGAAGTGCCCTCGCAGGTACTAGCAGCCAGCTTAACAATTCCACCGTCAACCTGCACAACCTGCCCATTCCCAACCTGGAGCCAGAGCGTCCTTCTGCCCCCTCATCCGCTGCTGAAGCCATAGAGCCCAAGAGCAGTCCACCGGAGCCGAAACGCAAGGAAGCCGGAAGCACTCGAGAATCTGCCCCTTTGGATCTTTCGTTGCGCCGTTCCCCAATCTCCCTGAACTCCTTGAGCCTGCGGCAGCGGCAGTTGCAGCACCTCCTGGACATGGAGGAAGTGCTTGGCCTGGGTGCCGTGGGAGGAGGCATTACTGGCAAGGAGAATATCAACACAGCTGCCACAGGTGGAGGAGGAGGTGGAGGAAATGGAGGAGGAGGAGGCGGAGGAAATGTCACCCCCGAGCAAATCGTGTGTGCCCCTTCCCTGCCGAGCAGTCCCTCGATGAGTCCTTCGCCCAAACGGCGAGCCATCAGCCCGAGGAGCTCAGGGCCAGGAAGTGCTGCCTCCATGTCGCCGCCCGGCCTGAATGTGGCGGTCCCCCATCGTCTAGAGATGCTCTCGGCCATGTTGCCGGCAGACTTTGGTCTCTCCGAGTCCCTGTTGGCCAAAACCAATCCGGAACTGGCCCTGAAACTGGCTGCGGCTGCGGCGGCGGCTGCAGTGGCCGGTGGGGCAAGTGGTACTACACCCGCCTTTCCGCCCGTGCCCGCCGCTCAAACGGGAGGCAACAACTCCTCGGGAGGGGGATCAGTCGGTGGCGGACAGCAGCCACAGATCTACGTGAAGCAGGGCGTGTCCAAGTGCAAGGAGTGCAATATCGTTTTCTGCAAGTACGAGAATTATCTGGCCCACAAGCAGCACTACTGCTCGGCCAGGAATCAGGATGGATCGGGCGATAGCGATTCCAAGTCGGCCGTTTCGCCCTCTAATCCCGGCGGAGCTGGTGGCTCTGGAGGCGGTGGTGCAGGGGCAGCCGCTGCGGTTGAAACATCTCCGGTGGCCTATCAACAGCTTATCTGCGCCGCCTGTGGCATTAAGTACACTTCTTTGGATAACTTGCGGGCCCACCAGAACTACTATTGCCCCAAGGGTGGGGCAGCTGCTGCCGCTCCAGCCGGGACACCCGCAGATCCTGGACAGTTGGCCATCGTGAAGGAGAAGTGCGGCAAGTGCAAAACCCTTCACGAGATAGGACTTCCCTGCCCAGCTCCCGCCTCCAGTCCACTGACAGCTCCCACCAACTCCAACTCCCAATCGAGCGCCTCGAATAGCGTCAACAAGTGTCCCGTTTGCGGCGTGGTCAGTCCCACGGCGGCTCTGGCCAGGAAGCACATGGAGATGCACGGAACGGTCAAGGCCTTTCGTTGCAGCATCTGCCAATACAAAGGCAACACGCTCCGTGGCATGCGCACTCACATCCGGACGCATTTCGACAAGAAGACTAGCGACGTGAACGAAGAGCACTACATGACCTGCATCTTCGAGGAGGAGAGTGCCAATGTGGCCCAGGAGCTGCCACCATCGGGAGCTGCAGTGGCACCTTTAGAGACCATGGAGCATCCGCCACAGCTGTTCAACTGCGATTACTGCAACTATGGTTCCACCTACAAGGGCAATGTGCTCCGTCATATGAAACTTTTGCACCCTCATGTGGCCATCACTTCCCCTTCGATTTCACCCGAGTCTCGGGAACAGGAGGTTATTGCCAACTCCACGCCCAATCAACACTCGAATGATGGCTCCAACGGCGAAGCCACAAGCTTCCACATCAAATCAGAGCCCTTGGATCCACCTGCCACACTGAGTCTGGTGCATGAAAACAACAACTCACCGATACCCACGCCACACATCAAAGCCGAACCCTTGGACATTGGAATAGACGTGGCACTGGCACCCCCGCCGGTGGCTTCTCCGCTGGGCAACAGCAGTGTGGCAGCTGCCACTGTAGCAGCAGCCGCCGCAGCTGCCGCCGCCGCCGAGGCAATGAAGAAGTACTGCTCCGTCTGCGACATATCCTTCAACTATGTGAAAACCTACCTGGCCCACAAGCAGTTCTACTGCAAGAGCAAGCCCATTCGCCCGGAGTCCAACGACAGTCCCAGTCCGAATCATCTAGCGGCCGGAGGAGGAGTGGGTCTGGGATTGGGCGTGGGGATGGTGGGTGGCGGCCAGCAGAAGAACAAGGAGAACCTGCAGGAGGCGGCCATTTGA
Protein Sequence
MSKFWRSEMQTASCACSLILQLHLHAMSMSMSTSTGLSRELSALSVRRHNLGQHRRTDSKDLTAQELGEEKQLHQLEDQLSDQMDDSTDNHENINNNNNDAEEDTVSDQPEETNAEDLMETEMMDQDHEPQPAAEEDGLDLPRNSPSTPPRSPIGSPRLIPKLEQPCTPPSEPEAEAEPSPCPSPSPIAPKLPKLRLNALLASDPALKPDAKELNLSEPRLLAPPPLIKPEVQPEIVEPLLKPARFMCLPCSIAFSSPSTLEAHQAYYCSHRNKDTEEDQGAGTGDKSAGGVGGASSGAAGSGSGSGSSEPPAKMARTGKQYACSQCSYSADKKVSLNRHMRMHQTSPATPSLVVASLPNLVQNGLPSTGVPANSLEESPSQQQTDRYCSDCDIRFNNIKTYRAHKQHYCSSRRTEGQLTPKPDASPGAGGGSSASASVASAVGVSVQGTAPGKLSPQTRNKTPTPAMVAAAAAAAAAAAAAAASLQAPPPQPFLALPTHPIIIVPCSLIRAASIIPGPLPTPSSGIVNPESTCFTVENGTIKPLATALLGSALAGTSSQLNNSTVNLHNLPIPNLEPERPSAPSSAAEAIEPKSSPPEPKRKEAGSTRESAPLDLSLRRSPISLNSLSLRQRQLQHLLDMEEVLGLGAVGGGITGKENINTAATGGGGGGGNGGGGGGGNVTPEQIVCAPSLPSSPSMSPSPKRRAISPRSSGPGSAASMSPPGLNVAVPHRLEMLSAMLPADFGLSESLLAKTNPELALKLAAAAAAAAVAGGASGTTPAFPPVPAAQTGGNNSSGGGSVGGGQQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQDGSGDSDSKSAVSPSNPGGAGGSGGGGAGAAAAVETSPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAAAAAPAGTPADPGQLAIVKEKCGKCKTLHEIGLPCPAPASSPLTAPTNSNSQSSASNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFDKKTSDVNEEHYMTCIFEEESANVAQELPPSGAAVAPLETMEHPPQLFNCDYCNYGSTYKGNVLRHMKLLHPHVAITSPSISPESREQEVIANSTPNQHSNDGSNGEATSFHIKSEPLDPPATLSLVHENNNSPIPTPHIKAEPLDIGIDVALAPPPVASPLGNSSVAAATVAAAAAAAAAAEAMKKYCSVCDISFNYVKTYLAHKQFYCKSKPIRPESNDSPSPNHLAAGGGVGLGLGVGMVGGGQQKNKENLQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00488262;
90% Identity
iTF_00550504;
80% Identity
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