Basic Information

Gene Symbol
rn
Assembly
GCA_035042385.1
Location
JAWNLK010000106.1:87595-90544[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.16 9.9 6.7 0.2 8 23 249 264 248 264 0.95
2 6 1.4e-06 9e-05 22.6 1.6 1 23 271 293 271 293 0.99
3 6 1.2e-07 7.4e-06 26.0 3.9 1 23 299 321 299 321 0.99
4 6 0.0017 0.11 12.9 4.4 1 21 327 349 327 351 0.93
5 6 0.0033 0.21 12.0 2.1 1 20 357 376 357 379 0.93
6 6 1.3e-06 8.2e-05 22.7 3.4 1 23 388 410 388 410 0.97

Sequence Information

Coding Sequence
atggaGGGTCGTTTAATCGAGTACCGTCCAATTGGCGGTGGCCTCGATTACCATCACAATTCTCCGCTAATTGGTGAGATTCCGCCGGCTGGAGGAGACTACTCACACGCCGTGCATCGCTCCATTGATCATCTGCGTAACAGTTTGAATGAGCGCGTGGCACTCGGACCATTGAGTGTGTTTTCCAACACGCCGGATCTGCGCAGCTCGGTGCTCAGCTATAGCCAACAtccgcaacagcaaccacaagtGACGCATCAGCctcaacaccagcagcagcagcaacagcagcagcagcatcaataTCACTTGAGTGGCGGCGGAGAGGCACTGCATCAGCCAAAGCCACCGCTTGAGAGCAGTTCCGCCTTGGCTATTGCAGatggcggcagcaacagttcCAAGCTCCAGGTTAATGAAGCTGTCGtgagcagcagtagcagcagcagcgccagtgGCTCCACAGCGCCGACGGGCTCCACACGTGGCCGGAAATCCCGCATCTATCCGAATCCCAATCAGCACATTGTGGTGACCAGCAACAGCGTGGATAATGGCGGCATACGTATGCAGAATGCAACGCTCAATGAGCGCAATCCTaatgcaaatccaaatccaaattcgaattcgaatccGCTTCCAATTCCAAATCCAACTCCAGTTAGTGGCAGcgttgccaatgccaatggcatCTCATCTTCAACCAGTTCGCCACATCATATGACGCATGATGTGAAGGATACCAAGATCTTCAGCTCGAAGGCGGACTTGCAGCTGCACACACAGATCCACATGCGCGAAGCGAAGCCCTATAAGTGCACACAATGCTCGAAGGCGTTTGCCAACTCATCGTATCTGTCGCAGCACACCCGCATCCATTTGGGCATTAAGCCGTATCGCTGCGAGATTTGCCAACGCAAGTTCACGCAGCTGTCGCACCTGCAGCAGCATATACGCACCCACACCGGCGACAAGCCATACAAGTGCCGTCATCCTGGCTGCCAGAAGGCCTTCTCCCAGCTCTCCAATCTGCAGTCGCATTCGCGCTGCCATCAAACGGACAAACCGTTCAAGTGCAACTCCTGCTACAAGTGTTTCTCCGATGAGCCCTCGCTGCTGGAGCACATACCCAAGCACAAAGAATCGAAGCATCTGAAGACGCACATTTGTCAGTACTGTGGCAAATCGTACACCCAGGAGACCTACCTGACCAAGCACATGCAGAAGCACGCGGAGCGCACCGACAAACGGCCACCGATAGCGCCAGGcagtgcagctgctgttgctgctgccgcagccgccgcggctgctgctggcggtcAGAGCAATAatgcgccagcagcaacagcagccagcaactcACAGCATCAGCGGAATAATTTGGTGTTGCCGCCCGTTTCAATAGCGCCCAGCGATAACAACTATTGGCCAAAAGTAAGTCCCGATTCAGCAGCGGCGTCCAATGCCATGGAAGTCatgcatcagcaacagcagcagcaacaacaacagcagcaacagcagcagcagcagcagcaacagcagcagcaacaacaacaacagcaacaacagcaacagcagccgcaccaCCATCACACGCAATTGGGCGTGCCACCGCAGCAACATGGCccgccgcaacagcaacaacagccgcaacacCATCACCCACAgcaacacacagcacagcaacagcagcagcaacaaccaccgCCCCAGCATGGCATGGAGGCCCACTACGTACAACCCACAGCACCTAATAGCAATCAGAGCAATGGCCATCCGTCGGAGCAACTGCAACCGCATCATCGCATTATGCCCGAACCTGTGCGAGAGGATATTGTATCCACACCCAGCACTGTGGGGCCATATGATGCGGCTTCAATAgcgaagagcagcagcaactcggCCTTTACACCGATCAATTCAATGCCGCCGCACTTGAATTCACTGAGCCACCATCCGATGGCGCAGCGTCCCTATCTCTATGATGCCATCAGTTTCCCCAATAAGAACGTCAACCAGAATAATGCCAATGCATTTCCCAATCAGCTGATCTCGCTACATCAGATCCGTAACTATGCGCATCAGCCGGCGGGCCTGATGGCCGGTGAGCATCTGCTCGGCGTTAGTGTTGGGCCCGGCAAGGATAAAGGATAG
Protein Sequence
MEGRLIEYRPIGGGLDYHHNSPLIGEIPPAGGDYSHAVHRSIDHLRNSLNERVALGPLSVFSNTPDLRSSVLSYSQHPQQQPQVTHQPQHQQQQQQQQQHQYHLSGGGEALHQPKPPLESSSALAIADGGSNSSKLQVNEAVVSSSSSSSASGSTAPTGSTRGRKSRIYPNPNQHIVVTSNSVDNGGIRMQNATLNERNPNANPNPNSNSNPLPIPNPTPVSGSVANANGISSSTSSPHHMTHDVKDTKIFSSKADLQLHTQIHMREAKPYKCTQCSKAFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHPGCQKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEPSLLEHIPKHKESKHLKTHICQYCGKSYTQETYLTKHMQKHAERTDKRPPIAPGSAAAVAAAAAAAAAAGGQSNNAPAATAASNSQHQRNNLVLPPVSIAPSDNNYWPKVSPDSAAASNAMEVMHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPHHHHTQLGVPPQQHGPPQQQQQPQHHHPQQHTAQQQQQQQPPPQHGMEAHYVQPTAPNSNQSNGHPSEQLQPHHRIMPEPVREDIVSTPSTVGPYDAASIAKSSSNSAFTPINSMPPHLNSLSHHPMAQRPYLYDAISFPNKNVNQNNANAFPNQLISLHQIRNYAHQPAGLMAGEHLLGVSVGPGKDKG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00518666;
90% Identity
iTF_00526813;
80% Identity
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