Basic Information

Insect: Drosophila engyochracea
Gene Symbol: topi
Assembly: GCA_035042385.1
Location: JAWNLK010000106.1:4634369-4637078[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 2.1e-05 0.0013 18.9 3.3 1 23 224 246 224 246 0.97

2 10 0.00076 0.048 14.0 1.7 2 23 272 293 271 293 0.97

3 10 0.003 0.19 12.1 0.0 2 23 352 373 351 373 0.96

4 10 4.3 2.7e+02 2.2 0.1 1 21 379 399 379 400 0.88

5 10 0.051 3.2 8.3 1.3 1 21 420 440 420 444 0.90

6 10 4.7e-07 3e-05 24.1 1.9 1 23 508 530 508 530 0.95

7 10 0.00011 0.0072 16.6 0.5 1 23 536 561 536 561 0.97

8 10 0.41 26 5.4 1.7 1 23 567 589 567 589 0.88

9 10 3.5e-08 2.2e-06 27.7 0.4 1 23 595 617 595 617 0.99

10 10 0.00067 0.042 14.2 1.2 1 23 623 646 623 646 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	2.1e-05	0.0013	18.9	3.3	1	23	224	246	224	246	0.97
2	10	0.00076	0.048	14.0	1.7	2	23	272	293	271	293	0.97
3	10	0.003	0.19	12.1	0.0	2	23	352	373	351	373	0.96
4	10	4.3	2.7e+02	2.2	0.1	1	21	379	399	379	400	0.88
5	10	0.051	3.2	8.3	1.3	1	21	420	440	420	444	0.90
6	10	4.7e-07	3e-05	24.1	1.9	1	23	508	530	508	530	0.95
7	10	0.00011	0.0072	16.6	0.5	1	23	536	561	536	561	0.97
8	10	0.41	26	5.4	1.7	1	23	567	589	567	589	0.88
9	10	3.5e-08	2.2e-06	27.7	0.4	1	23	595	617	595	617	0.99
10	10	0.00067	0.042	14.2	1.2	1	23	623	646	623	646	0.95

Sequence Information

Coding Sequence: ATGGATTCAAGATCAGAGCTTTACGATGATGGTGAATTCGTGATGGCCGAGTTCGAGCTCGATGACGATTTGATGGTGGACAGCAATGACATACAGTCAGGTTCCACTCTACTGGTGTCCAATGAGAGCAATGGTCTCCTCGGTCACGAGGATTTGGCCAAGTTCTTTGAGCTCCAGGACGGCTTTCAGATACCCGCCGAGGAAGTTGTGGAACGCACGTTGACAGATACGGCGCTAATGGGAATCCTGCATGAAGCCAACGGACAAATCGATTTTGATCCGGAAGCAGAGCAACTCAAATTACGCGAGTTCTTATCGGGCGTTAACAATTGCATGGAGCTGAATGTGTTGCCAGGTGTGGTGGTCGAAGAGAATAAAAGTCCAGCCCTCCGTTTCATCCTGTGCTCCAATTGTAACGGAATCTTCGATACGCCCGCATTCCAAAATCACATCTGTGAATACGATGCGAACCAGAAACAAATCGTAGCTCAGCAATTACCAGCACAGCCGGAGAAGAAGGCATCTTCGTCACCAAGGATAGCGAGCAGCGAGCGCATTATCGTTGAGAACCAGGTGCGCATGCGTCGCTATATAAAGGATGAGCTCAAGTATGATCTGGAGACGGGCTACGACAGTTCCAAGGTGAAGGAGTCGACGGTCAAGGGCACCCACGAGTGCAGCATCTGTGAGCGCAAGTTTGTTCACTCCTCCGGCTTAACGCGTCACTTGGAGAAGCATGCTCTGGACCAAATCCCCGCACAGGCAACACTGCAACAGCATCACGCATCAAGGCTTGGCGTTCTTGTTGTCCTCAAATGCAAACACTGTGGACGCATTTTCTTCAACGTCAAGCTGGCGCTGAAACACATCCGTGTGCATCGCTCGACTAGCGACGTAGTCCAATCCACAAATGTGgataaagtgaaattaaagCATCATCTCGAATTGCTACTGATGGAGGACAAGCAACTACAATTGATCACCAAGCTGGAGAAGATACCGTTGGATCGGCAGGAAGAAATGTACAAAAACCATGTGGTGGCTAATGTCCTCCAGTGCGAGTTTTGTGACTATATCTTTGCCGATGTTGCCGCGCTGCTGCGCCACTCGGCCACCCATATGCCGGAGCAGCGGTTCGAGTGCACCGCGTGTGATCTGCGCCTGACCACCGCAAAGGAGGCCAGTGTTCACTTTCAAACCGACTGTGTCTATATGCGCGAGGAACTCAAGGAACTGCAAGTTGCGCTGAATCGTCTATTTGTGTGCAATGTGTGCAAGCTGAAATATGCCAACGTGGAACTGCTTCAGGAGCATCGCTACAGTTGCCTCCACTTCTTTCCGCGGCTCAGCGAGACCGGCACACGGTTGATGTTGCCCTGTGAGTTCTGTGCCACAAATTTTCAGTGTGCCAACGAGATACAGGCGCACTACGAGGAGAAGCATCTCAATCGGAAGAAGCGGGAGAAGGAACAGCTGCGCAACATCAGCAGTGCATCATCATCCAAGGTCCGACTGCGTCAATATCTATGCGACATCTGTGGCAAATCCTACACACAGTCCAGTCATTTGTGGCAACACCTCCGCTTTCATCAGGGTGTGAAGCCATTTGTTTGCCCGGAAGCGAACTGCGGTCGCAAATTCACCATACGTCCGGATCTCAATGATCACATACGAAAGTGTCACACTGGGGAACGGCCGTATCATTGTCTGGTTTGCGGCAAGCGTTTTCTCACCGGCTCCGTGTTCTACCAGCATCGACTCATCCATCGTGGCGAGCGGCGATACGAGTGTGAAGAGTGCGGCAAGCGGTTCTATCGCGCCGACGCTTTGAAAAACCATCAGCGCATTCATACGGGCGAGAAGCCTTACGATTGTCCATTCTGCACGAAAACGTTCCGGCAGCGTGGCGATCGCGATAAGCATGTGCGGGCGCGTCACTCCCACTTGGATGAGAATGCTCGCCTAATGATGCGAATGCAGAAGTTTGAACTGGAGAAGGCGGCTGCGCTGAAGGCGAAGCAGTTGCATGAGGGTGGAATTGAATATTTGGTGGAGTCGGGGGATGCGACGTCTATTCATTCGGTAGCATCTCCGTCATCACTTGAGCCAAATTTCGATTACAGTGAATACCCCGAAGAAACTGAAATTGTATCACTGCCAATTAAAAACGAGGAGACAGATATAATGTCGTATATGGAATTTGAGGGAGTAGAATCAATCGAACCACCACCGTTCAAGCTGGAAAATAATGGAAACGTCAAGGTTGTCGTGGTTGAAAATAATTCTTTGCAGCCATTCTATTTCTAA
Protein Sequence: MDSRSELYDDGEFVMAEFELDDDLMVDSNDIQSGSTLLVSNESNGLLGHEDLAKFFELQDGFQIPAEEVVERTLTDTALMGILHEANGQIDFDPEAEQLKLREFLSGVNNCMELNVLPGVVVEENKSPALRFILCSNCNGIFDTPAFQNHICEYDANQKQIVAQQLPAQPEKKASSSPRIASSERIIVENQVRMRRYIKDELKYDLETGYDSSKVKESTVKGTHECSICERKFVHSSGLTRHLEKHALDQIPAQATLQQHHASRLGVLVVLKCKHCGRIFFNVKLALKHIRVHRSTSDVVQSTNVDKVKLKHHLELLLMEDKQLQLITKLEKIPLDRQEEMYKNHVVANVLQCEFCDYIFADVAALLRHSATHMPEQRFECTACDLRLTTAKEASVHFQTDCVYMREELKELQVALNRLFVCNVCKLKYANVELLQEHRYSCLHFFPRLSETGTRLMLPCEFCATNFQCANEIQAHYEEKHLNRKKREKEQLRNISSASSSKVRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEANCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDENARLMMRMQKFELEKAAALKAKQLHEGGIEYLVESGDATSIHSVASPSSLEPNFDYSEYPEETEIVSLPIKNEETDIMSYMEFEGVESIEPPPFKLENNGNVKVVVVENNSLQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00557382;
90% Identity: iTF_00498343;
80% Identity: -