Basic Information

Insect: Drosophila emarginata
Gene Symbol: topi
Assembly: GCA_037075365.1
Location: JBAMCD010000221.1:813524-816111[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00013 0.012 16.5 1.0 2 23 245 266 245 266 0.97

2 9 0.072 6.3 7.8 0.4 2 23 293 314 292 314 0.93

3 9 0.1 9.2 7.3 0.0 2 23 374 395 373 395 0.95

4 9 0.00025 0.022 15.6 0.4 1 22 442 463 442 466 0.90

5 9 5.3e-07 4.6e-05 24.0 1.9 1 23 524 546 524 546 0.95

6 9 0.00054 0.047 14.5 1.1 1 23 552 577 552 577 0.96

7 9 0.46 40 5.3 1.7 1 23 583 605 583 605 0.88

8 9 3.9e-08 3.4e-06 27.6 0.4 1 23 611 633 611 633 0.99

9 9 0.0018 0.16 12.9 2.0 1 23 639 662 639 662 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00013	0.012	16.5	1.0	2	23	245	266	245	266	0.97
2	9	0.072	6.3	7.8	0.4	2	23	293	314	292	314	0.93
3	9	0.1	9.2	7.3	0.0	2	23	374	395	373	395	0.95
4	9	0.00025	0.022	15.6	0.4	1	22	442	463	442	466	0.90
5	9	5.3e-07	4.6e-05	24.0	1.9	1	23	524	546	524	546	0.95
6	9	0.00054	0.047	14.5	1.1	1	23	552	577	552	577	0.96
7	9	0.46	40	5.3	1.7	1	23	583	605	583	605	0.88
8	9	3.9e-08	3.4e-06	27.6	0.4	1	23	611	633	611	633	0.99
9	9	0.0018	0.16	12.9	2.0	1	23	639	662	639	662	0.96

Sequence Information

Coding Sequence: ATGAGTGGCTCAGATTTATGGAACTTACAGTCGAATGGGACAACTGGCGAATATACAGTTGCCGAAATTGAGGTTGAAGATGGAGCACAATTTGTTATAGATGATTTGCAATCGGGGGCCACTGTACTAGCGGCCAATGAGGGTGATGGTAACATGGAACGCATTTTTGGTCATGAAGAGTTGTCGAGATTTTTTGTAGCGGCACCAAAAGCCAACATTGAAATTCCCACTGAGGTGGTGGTGCAACGTACTTTAGCGGATCCGGCACTGAAGCAGATTTTGCAGGAGTCAGATGGCAAGGCAGGATTCGATCCAGAGGCTGAGCAGATTAAAATCCGTGACTTTCTTGCTGGCGTTAGTAAAGGCAAAATGACCACGGAGGAAAGCGTCTTTTTGGCACCTAGGCCGGGAACATCGTCTAGTGTTGCACCAACAAGTCGCACCGTCAAATGTAGCCGCTGTGATATGTCCTGTGATGTGCATTCTTTCAATAAACATGAATGCGAAGGCGAGCGCAAACCGATCGAGAAGGCAACAACTGCAAAGCAAGAAAAGCCGCCAGCATCCAAAGTGGTTTCGACAACACCACCAACTCAAATTAAACCGGCCAATGAGCGCGTCATCCTGGAGAACCAAATACGGTTACGTCGTTACATGAAGGATGAACTGAAATGCGATCTGACCACCGGCACGGTCAATTCCCGGTCCAAGAAGGCGGCAAAGGGGCCGAATGAGTGTACCATGTGTGAGCGTAAATTCGTACATGCTTCAGGCTTGGTACGTCACTTGGAGAAGCATGCTTTAGATTTAATTCCCACACATAACATACAACCACACGTGATACCACCACCAGCTCCAGGATTACATGTAGTTCTCAAATGCAATAGTTGTGGTCGTATCTTTTATAACACAAAGTTTGCCAATGAACATGTCCTGATTCACTATCCACCGCAGCCGAAGCTAAGTGAGCCCAAAGCCACCATAAAGGATAGCTTTGATATGGAACAGTTTTTGCTGGAAGGTGACCAACTACTCGCCACCCTCTCCCAAGACATTTGCAATGTTATATCTCCCTTGGAGACCGATTTATTCGAGACCGTAATTGTGGGCAGCGTCCTGCAGTGCGAGTTctgtgaatatatttttgcggGAATATCGGAACTACTCCTGCATTCAGCAACCCATGTTGCTGAGAGGCGATTTGAGTGCACCGCATGTGATCTTACCATGAATACGGCTAAGGAGGCTAGTGTTCACTTTCAGACCGACTGCATTTTTATGCGTGAAGGACTTAAACTTCTCAATGTCTCATTAAATCGTTATTTTGTGTGCAATGTATGCGAGCAAAAGTTTTCCAATGCTGAGCTACTGCAGGAGCATCGatcCAGCTCCTATCATTATTTTCCTCGTCTCAGCGAGAATAGTAAACGTCTGCTCCTTCCTTGTGAGTTCTGTGaagtaaattttgaatttgctcATGAGATTTCACCACACAACGAGGAGAAGCAtctgaataaaaagaaacgtGAGAAGGAGGCACGCAACACTGGACCCGGTCGGGTTCGTCAATATTTGTGCGACATCTGCGGCAAATCTTACACTCAGTCCAGTCATCTTTGGCAACACTTGCGTTTCCATCAGGGCGTTAAACCGTTTGTTTGCCAGGAGGAGAACTGCGGCAGGAAGTTCACTATTCGTCCAGATCTGAACGATCACATTCGGAAGTGCCATACTGGAGAGCGTCCGTATCATTGTCTGGTTTGTGGCAAGCGTTTCCTCACGGGATCCGTGTTTTATCAGCATCGCTTGATTCATCGCGGGGAGCGGCGCTATGAATGCGAGGAGTGCGGCAAGCGATTCTATCGTGCCGATGCCCTGAAGAACCATCAGCGTATCCATACGGGTGAAAAGCCATATAGCTGTCTTTTTTGTACCAAGACATTCCGCCAGCGTGGCGATCGCGACAAACATATCCGTGCACGCCACTCGCATCTGGATGCCAATTCGCGCCTCAtgatgcaaatgcaaaaattccaATTAGAGTCGGCTGCCAAGGCCAAAAGAAATGGCACTCAACCAGAGCGTCCCAAGGAAAATGATGAATCAGCGGAAGGTGATGAGAATGGCAAAATTGACGCCGTAGCCCTTACCAAAATGTCGGAGCAGCAGGAATTACTGGCTTCTATGGCCATTAAAGAAGACTATGTTCCAGTTACCATTATGGTGGAGACCGCTCCGGCTATTCAGCAGAATATAATGTACGAAAACCagatgcaaatgcaaatgcagatGCAGGTACAGGATGCGATCAACACCAATGATAATATTGTGATGTCTATTTTTGATCCTGTACCAGAGCCAAGTCAATCTAGCATTTTGGAAAGCATTCCTTTGCTGCAGACCAGTGATCATGCCAAAGTAGTGGTGGTCAAAAATAATCCCTCACAGCCAATGTTTTCAGATTCTTATTTgtga
Protein Sequence: MSGSDLWNLQSNGTTGEYTVAEIEVEDGAQFVIDDLQSGATVLAANEGDGNMERIFGHEELSRFFVAAPKANIEIPTEVVVQRTLADPALKQILQESDGKAGFDPEAEQIKIRDFLAGVSKGKMTTEESVFLAPRPGTSSSVAPTSRTVKCSRCDMSCDVHSFNKHECEGERKPIEKATTAKQEKPPASKVVSTTPPTQIKPANERVILENQIRLRRYMKDELKCDLTTGTVNSRSKKAAKGPNECTMCERKFVHASGLVRHLEKHALDLIPTHNIQPHVIPPPAPGLHVVLKCNSCGRIFYNTKFANEHVLIHYPPQPKLSEPKATIKDSFDMEQFLLEGDQLLATLSQDICNVISPLETDLFETVIVGSVLQCEFCEYIFAGISELLLHSATHVAERRFECTACDLTMNTAKEASVHFQTDCIFMREGLKLLNVSLNRYFVCNVCEQKFSNAELLQEHRSSSYHYFPRLSENSKRLLLPCEFCEVNFEFAHEISPHNEEKHLNKKKREKEARNTGPGRVRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAAKAKRNGTQPERPKENDESAEGDENGKIDAVALTKMSEQQELLASMAIKEDYVPVTIMVETAPAIQQNIMYENQMQMQMQMQVQDAINTNDNIVMSIFDPVPEPSQSSILESIPLLQTSDHAKVVVVKNNPSQPMFSDSYL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00600541;
90% Identity: iTF_00600541;
80% Identity: -