Basic Information

Insect: Drosophila emarginata
Gene Symbol: MET32
Assembly: GCA_037075365.1
Location: JBAMCD010000106.1:1246549-1251189[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 22 0.00087 0.076 13.9 1.1 1 23 210 232 210 232 0.96

2 22 0.00064 0.056 14.3 1.3 1 23 238 260 238 260 0.98

3 22 0.21 19 6.4 1.3 2 23 292 313 291 313 0.96

4 22 0.0033 0.29 12.1 3.1 1 22 388 409 388 411 0.90

5 22 2.3 2e+02 3.1 0.4 3 23 482 502 481 502 0.95

6 22 0.0077 0.68 10.9 1.4 1 23 582 605 582 605 0.96

7 22 0.84 73 4.5 6.0 1 23 644 667 644 667 0.97

8 22 0.00017 0.015 16.1 0.5 2 23 692 713 691 713 0.97

9 22 5.4e-06 0.00047 20.8 4.4 1 23 721 743 721 743 0.98

10 22 0.0045 0.4 11.6 1.2 1 23 890 913 890 913 0.95

11 22 0.034 3 8.9 1.2 2 22 922 942 922 942 0.94

12 22 1.4 1.3e+02 3.7 5.8 1 23 951 974 951 974 0.95

13 22 6e-05 0.0053 17.5 6.0 2 23 989 1010 988 1010 0.96

14 22 0.00014 0.012 16.4 0.9 1 23 1016 1038 1016 1038 0.98

15 22 0.0033 0.29 12.1 0.2 2 21 1065 1084 1064 1085 0.94

16 22 0.0089 0.78 10.7 4.8 1 23 1131 1154 1131 1154 0.96

17 22 7.4e-05 0.0065 17.2 1.8 1 23 1247 1270 1247 1270 0.98

18 22 5.9e-06 0.00051 20.7 0.2 2 23 1306 1327 1305 1327 0.95

19 22 0.00082 0.072 14.0 3.0 1 23 1333 1355 1333 1355 0.99

20 22 2.3e-06 0.0002 22.0 2.0 1 23 1361 1383 1361 1383 0.97

21 22 2e-07 1.8e-05 25.3 2.4 1 23 1389 1411 1389 1411 0.99

22 22 0.00076 0.067 14.1 0.1 1 21 1417 1437 1417 1441 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	22	0.00087	0.076	13.9	1.1	1	23	210	232	210	232	0.96
2	22	0.00064	0.056	14.3	1.3	1	23	238	260	238	260	0.98
3	22	0.21	19	6.4	1.3	2	23	292	313	291	313	0.96
4	22	0.0033	0.29	12.1	3.1	1	22	388	409	388	411	0.90
5	22	2.3	2e+02	3.1	0.4	3	23	482	502	481	502	0.95
6	22	0.0077	0.68	10.9	1.4	1	23	582	605	582	605	0.96
7	22	0.84	73	4.5	6.0	1	23	644	667	644	667	0.97
8	22	0.00017	0.015	16.1	0.5	2	23	692	713	691	713	0.97
9	22	5.4e-06	0.00047	20.8	4.4	1	23	721	743	721	743	0.98
10	22	0.0045	0.4	11.6	1.2	1	23	890	913	890	913	0.95
11	22	0.034	3	8.9	1.2	2	22	922	942	922	942	0.94
12	22	1.4	1.3e+02	3.7	5.8	1	23	951	974	951	974	0.95
13	22	6e-05	0.0053	17.5	6.0	2	23	989	1010	988	1010	0.96
14	22	0.00014	0.012	16.4	0.9	1	23	1016	1038	1016	1038	0.98
15	22	0.0033	0.29	12.1	0.2	2	21	1065	1084	1064	1085	0.94
16	22	0.0089	0.78	10.7	4.8	1	23	1131	1154	1131	1154	0.96
17	22	7.4e-05	0.0065	17.2	1.8	1	23	1247	1270	1247	1270	0.98
18	22	5.9e-06	0.00051	20.7	0.2	2	23	1306	1327	1305	1327	0.95
19	22	0.00082	0.072	14.0	3.0	1	23	1333	1355	1333	1355	0.99
20	22	2.3e-06	0.0002	22.0	2.0	1	23	1361	1383	1361	1383	0.97
21	22	2e-07	1.8e-05	25.3	2.4	1	23	1389	1411	1389	1411	0.99
22	22	0.00076	0.067	14.1	0.1	1	21	1417	1437	1417	1441	0.91

Sequence Information

Coding Sequence: atgttgcCCTCGGACATTTGTCGTACTTGTGCCACGCAGCACAATAATTTATTGCCGCTTGCCTCCTGTTCGGAAAAACTGCAAGAATTAACACAAATTCCTCTCTTGGAGCAGGGCGATGAAAATTTACCACAGCATTTATGTGCCGATTGTTTGGCCAAATTGGAGAATGCTTATGCGTTTGTGGAGCAAGCGCGGAAGGTGAACAGGGAGCTGTTAATGAAGTTAAGGCAGTGCTTCCTGGAGGAGACACCTATTGATATACCAATACCCAACACCATGCAACAGCagattaaaatggaaatggacgAAGAGGAAGTTGGCCACCAACAACTAGATGAGGAGGAGGCAGCAGCCACAAGATTGGAACTAAAATGGCAGGCGGATAGTGAAGCAGAAAGCGAACCAGACGAGGACCCTGCTGGTTGTAAAGAAGACGAATACCAACCATATCAGCTTAGACGGAGCCTACGTAAGATTAAACAGCAATCCGATAGTGAACAAGAGGATCAGCAGCGGGAGGAGGAGAAAAACGAACTGAGTCTAAGCCCAGAGCAGCCACCAAAACGTCGTCGTGGTCGTCCTCCACGAGTGGCAAAATTGCAAGCTCTTAATTCGGATGGGCGGCATGCGTGTTCCGAGTGTGGGAAAACCTTCTCATGGTACCGAGATATGCAGCGTCATGCCCGCGTTCATTTCGAAGATGCCGCATTTAATTGTCCACAGTGTGGCAAGGGATTCCTACGGAAGGATAAGTATATGTCTCATTTGAAGTCCCATGAGAAGCGCCTGGCAAAACGAGAAGTTGTAGAGGTGGCTAAGGAATGGAGATTCGCTGAACGACTGTATAGTTCTGGCCAACTAAAGCTTATGGAATGTAAGTTATGTAACCTCAAATGTCAAAGTATAAAAGATTTAAGAGCCCATGTAGAGAGCCATTCATCCAAAGAAACTCTCAGCCAACTGCAGGTGGATCAAGAAGCGGTGAAGGAAAACTTTGGCGATGAAAATGTTGACATAGAAAAAGTCAAAGATTTAATAACGAAAGATATAAGTGAGGGGCACTTGGATAAATTCTGTGCTGTGGTGAACTCCCATGGCTATGAATTATGTTTAAGTGATTCTGATGAAGATTTGATTTCAGAAGGCGAAGAACCTAAATACCACTGTAATTCTTGTAACCTGCCTTTTAAGCGCAAGCATCTCCTTATACGTCATACCGTAGAGGAACATTCGCAATTGCACAATCAGCCCCAAATACGGTGTAATCTATGCCACATTGGTTTCGTCTGCTTCAATTTGTATGATCAACACCGACGTTCGCAGTGCAATGGTAAATTTAAGCGGTATGGATGTCGCAAGTGCCCTGGAAAGTTTATTTGGTTGGAGAATCTAGAAAAACATGACTGTGTTCAAAATAGAGAGGAAGACAAGCAGATTCTTTGCTGCCTATGTGATTCTCAGCTGCCCAGTTTAGTCCAATTAAGGGCCCATTTAATCAGTCATCGAGATGGCTTAACTGGCATTGATCCTCTATACCAAGCGACATTTTTCCGCTGCTATTATCCAAATGGCTTGGCATGCAGCCAGTCTGAACTAAGCTCTCGGATTGTTGGTGACTTTGAGGCTCAAGATTTTAGTCGCTATTATAATGCTAGCCTTAGCTCTGGCCAAGAATTGGATCTCTACGACTCTGATACGGATGAGAGTGATGAACCGGGAAAGTCTCAAGAGAAGACCGTTCACACATGTCCCCTATGCAACGAATCAATGAAGCGTTTAACCAATCTTCTCGAACATCAACAGAATTCCCATCAGCAAGAGATTGAATCGTTTTCTTATTCTTGTAAGAATTGCTCCGAAAGATTTCTCTGCGATGCTCTCCTACAACAGCATCGTCGTCGGTCATGTGGCAAGGCCCATGCTAGATTCCATTGCCAGCTGTGCCATATGCATTTCGTGTGGCAAACAAACTATGAGCAACATTTGCGTGTGAATCACCCATCAGACAAGGATTTAGATCAAGGATTTGCTATCAAGCGCAaatctgctgctgttgctgctgccaagCTGAAATGCAATGAGTGCGAAAAGGTCTTCATCTGGCCGAAAGACCTTAATCGTCACAAGCGCATGCATCAGCCCAGAACGGCATCTCAATTTGAGTGCCCACACTGTGAACGAAAATTCCATCGCAAAGATGGTCTCAAGTCGCACATGCGAGTGCACAGCGAATACCAGCAGATAGAGAAGGTTGAGAATGATGACCAAATTAATGATGAGAAATCCGCATCAAGCCAGATTTTAGCTGAACTTAGTCGGCCTCATGGCTGTAAGCGAATTCAATGCATGATTTGCCTATCCCAACACTCAAAAATAGCGGATCTGAGATGCCATCTAATGAAACATCAATTTGTCATCAGTTTGCCTCCTGAGAGAGACCAAGATATAGTTGGAGTTTCCAAATCCTTATATCCTGAGCTCAATGTGGCCCTATCCAGAGATCATTTGATATCACGTATTATGAATGACATAGGCAAGGGTGTAGAACTAGAGAGATTCATATCCATAACCAATGAAGCTGGCATTGAACTTAGTTTGGATAGCAGCGAAACGGATACAGATTCGGAAGAGGAATCGAATGATAGGCGGCAGAAGTTGAACCGATATTCTTGCTCCATTTGTCAAGTGgaagtgaaaagaaaacatcaaTTATATGCCCATCAATTGGAGCAGCATTCTAATGGAGAGGTAGGCACAAATGTGTGCTCGCATTGCCAGTCAAGATTTGTGAGTGAGCAACTACTTGAACATCATTTAAGATCCCAGTGCAGAAATAATCAGAAACGGCATCAGTGCAGGAAGTGCACTTTGCGCTTCCGTTGGAGGGACAACCTTAAGCTCCATTCGAATGTTTGCCATCAGGCAGATGATTCCCTATTAGGGGCAGATGGTGGAGAATTGCATTGCAAGGAATGCCATCGCAGcttcaaaatgcaaaaggaTTTGACCCGTCACATGCTGATGCACTCAGACACAAGTATCTATCGCTGTCGTTGGTGTGCGCGTCGCTTCTATCGCCAGGCCAATCTTCTACAGCACATAGAACGACATGGCATCAGCGCTGATCAATTGCCTTACGCTGAATCACTACTAAATTCATATAATCATCCACATGGTCAGAAGGTCATCGAATGCAAAGTGTGCAATATAAACTTTAACTCCATTACTGAGCTACGCCGCCACTTAAAGAATGCTCCCAAGGACTCGCACCATGACCTTGCCTCCATGAAAAATTATTCTATAACCAATCAATTGGGCTATGAGTTGCATTTGGACGATTCTGAAACAGATACGGAGGACGTCAAATCTGGAGGCAGTAACGAGGTTTACACTTGCAGCATGTGTCACTTGCGTTGTGCAAGAAAGTATGAACtctatcagcatcaacaggcTATGCACAGGTTGGAGCGAATCCCAGATGGCTGCGATCAGTGCATTTTTAAGAGCGTCTCTGATGACATTATCGAGCACCATAAGCGTAATCAGTGTAAAAATCAGGAGAAGCCctttaaatgtattaaatgtggttataaatttatgtggGAACCCAATATGTTAATACACGTGCAACTTCAGCATGCAAAAACTGAAGAGGAAGAGCAAATTATAGAACAACCCATGGAACAACCAGACTCAATTATAAATTCTTCAAACccaaaacaaatgcaacaaatctTCCAATGCGCTCTCTGTCCCAGGAAATACAATCGCAAAGATCGTCTTACGGCACATATGAAGAAATTCCACAATCCGGGTGGGACTACGAACCAATCCCCAGCTCCATCAAAGAAACCCCCATCAgtagcagcatcatcatcatctttagCTTCCCCTAAGCAACCAAAACTATTTCTCTGCGCATTCTGTGGCAAGGCAGTTAGTTCCTCCTCAAATCTCATTATCCACATGCGTCGGCACACTGGTGAGAAGCCGTTTAAATGTGATTTCTGCGAGATGGCTTTTCCTCGTTCCTCGGATCTTCAATGTCATCGGCGCACACATACGGGCGAGCGACCACATGTCTGCACAGTTTGTCAAAAAGGTTTTGCCAGATCCTATAAACTGCAACAGCATATGCGTATCCACAATGGAGAACGACCATACAAGTGCACATATTGCGAGAAGAGTTTCACCCAATCCAACGATTTGACCCTACACATACGTCGACACACCGGAGAGCGGCCATACCAATGCGGTATCTGTGGCGAGCGGTTCATCCAGGGCACTGCCTTAAAAAATCATCGTCTGCAACAAGGACACCATGAACCAGGCACTCCGGGTGGATTGCCTGGAGAGGCACCCCCAAGGCGCACAGTTCTCCAGCAATTCACAGGCgaatga
Protein Sequence: MLPSDICRTCATQHNNLLPLASCSEKLQELTQIPLLEQGDENLPQHLCADCLAKLENAYAFVEQARKVNRELLMKLRQCFLEETPIDIPIPNTMQQQIKMEMDEEEVGHQQLDEEEAAATRLELKWQADSEAESEPDEDPAGCKEDEYQPYQLRRSLRKIKQQSDSEQEDQQREEEKNELSLSPEQPPKRRRGRPPRVAKLQALNSDGRHACSECGKTFSWYRDMQRHARVHFEDAAFNCPQCGKGFLRKDKYMSHLKSHEKRLAKREVVEVAKEWRFAERLYSSGQLKLMECKLCNLKCQSIKDLRAHVESHSSKETLSQLQVDQEAVKENFGDENVDIEKVKDLITKDISEGHLDKFCAVVNSHGYELCLSDSDEDLISEGEEPKYHCNSCNLPFKRKHLLIRHTVEEHSQLHNQPQIRCNLCHIGFVCFNLYDQHRRSQCNGKFKRYGCRKCPGKFIWLENLEKHDCVQNREEDKQILCCLCDSQLPSLVQLRAHLISHRDGLTGIDPLYQATFFRCYYPNGLACSQSELSSRIVGDFEAQDFSRYYNASLSSGQELDLYDSDTDESDEPGKSQEKTVHTCPLCNESMKRLTNLLEHQQNSHQQEIESFSYSCKNCSERFLCDALLQQHRRRSCGKAHARFHCQLCHMHFVWQTNYEQHLRVNHPSDKDLDQGFAIKRKSAAVAAAKLKCNECEKVFIWPKDLNRHKRMHQPRTASQFECPHCERKFHRKDGLKSHMRVHSEYQQIEKVENDDQINDEKSASSQILAELSRPHGCKRIQCMICLSQHSKIADLRCHLMKHQFVISLPPERDQDIVGVSKSLYPELNVALSRDHLISRIMNDIGKGVELERFISITNEAGIELSLDSSETDTDSEEESNDRRQKLNRYSCSICQVEVKRKHQLYAHQLEQHSNGEVGTNVCSHCQSRFVSEQLLEHHLRSQCRNNQKRHQCRKCTLRFRWRDNLKLHSNVCHQADDSLLGADGGELHCKECHRSFKMQKDLTRHMLMHSDTSIYRCRWCARRFYRQANLLQHIERHGISADQLPYAESLLNSYNHPHGQKVIECKVCNINFNSITELRRHLKNAPKDSHHDLASMKNYSITNQLGYELHLDDSETDTEDVKSGGSNEVYTCSMCHLRCARKYELYQHQQAMHRLERIPDGCDQCIFKSVSDDIIEHHKRNQCKNQEKPFKCIKCGYKFMWEPNMLIHVQLQHAKTEEEEQIIEQPMEQPDSIINSSNPKQMQQIFQCALCPRKYNRKDRLTAHMKKFHNPGGTTNQSPAPSKKPPSVAASSSSLASPKQPKLFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDFCEMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFARSYKLQQHMRIHNGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGICGERFIQGTALKNHRLQQGHHEPGTPGGLPGEAPPRRTVLQQFTGE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00612227;
90% Identity: iTF_00555983;
80% Identity: -