Ddem004027.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila demipolita
Gene Symbol
NFYC
Assembly
GCA_035042405.1
Location
JAWNLI010000047.1:1426507-1429069[+]

Transcription Factor Domain

TF Family
NF-YC
Domain
NF-YC domain
PFAM
AnimalTFDB
TF Group
Other Alpha-Helix Group
Description
Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 1.9e-51 1.6e-47 162.2 0.0 18 127 136 245 125 283 0.94
2 4 2 1.7e+04 -13.4 34.0 153 228 361 437 344 441 0.84
3 4 0.32 2.7e+03 -2.5 61.1 141 266 405 533 397 543 0.67
4 4 2 1.7e+04 -27.0 51.9 150 235 538 622 522 664 0.54

Sequence Information

Coding Sequence
ATGGCCATGTACGCCACCAACAATGGCAGCACAAATAAGGCGCCAAATAGCAATGCAACAACGATGTTTGACAACACAATAACCGTAACGCCAATCAAAATGGAGCTCAGCGAAGCTCTGACAAAGCCAACGGGAGTTGGAGCAACACCGCCGCTGCGTAGGCCAAATGCCGTTATTGTCACTACACAGCAGCTGGCAATGCCCAATGCAATGCACTCGCTGACaaacagtagcaacaatagcaacaacagcggcagcaacactGGCAGTGGGAGCAGCAACTCTAGCGCCATCTATACGGGCATCAGTGTGACGTCAATGCCAACAGTGGCAACGGCAGCATCAGCGCCCAAAGAGAAGGCAGCCAAAGCGACCAGAGTTCAAGTAGCACGCAAACCGCCGCCGACTATTGACAACTTTTGGCCAAACATATTGGGCGAGGTAAACGGGATTGGTCAGGTGGATGCCAAGCATCAGGTATTACCCCTAGCGCGCATCAAGAAGATCATGAAACTGGACGAGAATGCTAAAATGATAGCAGGCGAGGCGCCGCTGCTGTTTGCGAAAGCTTGTGAATATTTCATCCAGGAGCTGACAATGCGCGCCTGGGTCCACACCGAGGAGAGTCGTCGTCGCACGTTACAGCGTTCGGATATTGCTCAGGCGATTGCCAACTATGATCAATTTGATTTCCTAATCGATATTGTGCCGCGCGAGGAGATCAAACCGTCGACATCGTCAACACAGAAAACCAAAGAGCCATCCAGCTCAGgtgtaacaacaacatcctcctcaaatgctgctgctcctgcgaatgctggtgctgctgttggcaacGCTGTTGCTTTGCCGACAGCAACTGCCGTTGTTAGCAATAGCAACCTGAACCATATcagcaacattagcaacaatattaacaacatGTCCAGCGTTAATTTCACAACGAATAATCTATTAGCTGGCGCCAATgtacctgctgctgctgctgccgccgccgctgctgcaacTGGGCTCAAGCTAGATGCGGCAACGGCCGAAGTGCTTGGCTTTGGCACCGTCACTCCGGATCTTTTTGCGGCAGCCCAAGTCGCAAGCAATAAtcaccagcagctgcagcagcttaccgcccaacagcagcatcatcaaccGCAACAATTGCAGATCATACAGCAAGGAGCCGGTGGCcagcaattgcaatattttattgcccTGCCTAACCAACAGCCCACTCAGCTAGTGCAGCAAAtccatcaacatcagcagcaacagcatcagcaacagcagcagctcggaCTGAATATTGTTGCCCAGCAGCCAACACAGCAGCTTATTCTCACCGCCGGACCCAATGGCCAGTTGACAGCGACGCCAGCGCCGACAAcagcccaacagcaacaaacggCGCTGCTTCAGAATTTGgctcagcaacatcagcaacaacaacaacagcaacaacaacagcagcaacaaatccaACTTATCCAGCAAGTCGTCACGCCTAACGGCGAGCTGACAAATGTGCCCATTGCGATAAATGCGAatcagttgcatttgctgcgtttacagatgcaacagcagcaacagcagcaacagcagcaagttgcTGCAGTgcaagcggcagcagcagcagcagctgcagcggcgcaacaacagcagcaacagcagcagcaggtgatAATCCCAACGCAATTGTTAACCGCACAGCAGTTATTGCAATTGGGCGGCACgccaacaaatgcaacaactgtgacacagcagcagctgcaactgcaccaacagcaacatcagcagcagcatcaacagcagcagcatcatcatcatcagcatatacatataaccaccaatccaaatccaaatggaaacaatgccaacaacacaatcagcagcagcagcaacaatagcaactcATCGTCAATATTCATAAATGCGGCGTCGAACGCCCAAGTTGCGACGCaggcgcaacagcaacaatcgcaGGGTATTGCAACATTAGGCAATGATCGTGGCTTCCGGTAA
Protein Sequence
MAMYATNNGSTNKAPNSNATTMFDNTITVTPIKMELSEALTKPTGVGATPPLRRPNAVIVTTQQLAMPNAMHSLTNSSNNSNNSGSNTGSGSSNSSAIYTGISVTSMPTVATAASAPKEKAAKATRVQVARKPPPTIDNFWPNILGEVNGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMRAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSTSSTQKTKEPSSSGVTTTSSSNAAAPANAGAAVGNAVALPTATAVVSNSNLNHISNISNNINNMSSVNFTTNNLLAGANVPAAAAAAAAAATGLKLDAATAEVLGFGTVTPDLFAAAQVASNNHQQLQQLTAQQQHHQPQQLQIIQQGAGGQQLQYFIALPNQQPTQLVQQIHQHQQQQHQQQQQLGLNIVAQQPTQQLILTAGPNGQLTATPAPTTAQQQQTALLQNLAQQHQQQQQQQQQQQQQIQLIQQVVTPNGELTNVPIAINANQLHLLRLQMQQQQQQQQQQVAAVQAAAAAAAAAAQQQQQQQQQVIIPTQLLTAQQLLQLGGTPTNATTVTQQQLQLHQQQHQQQHQQQQHHHHQHIHITTNPNPNGNNANNTISSSSNNSNSSSIFINAASNAQVATQAQQQQSQGIATLGNDRGFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00501788;
90% Identity
iTF_00557193;
80% Identity
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