Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 5.9e-06 0.00038 20.7 0.6 2 23 121 142 121 142 0.97

2 6 1.3e-06 8.1e-05 22.8 2.5 1 23 148 170 148 170 0.98

3 6 0.00052 0.033 14.6 4.5 2 23 177 198 176 198 0.96

4 6 0.0031 0.2 12.1 1.7 3 23 206 227 204 227 0.95

5 6 0.00012 0.0078 16.6 0.7 1 23 240 263 240 263 0.96

6 6 0.0035 0.22 12.0 4.7 1 23 269 291 269 291 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	5.9e-06	0.00038	20.7	0.6	2	23	121	142	121	142	0.97
2	6	1.3e-06	8.1e-05	22.8	2.5	1	23	148	170	148	170	0.98
3	6	0.00052	0.033	14.6	4.5	2	23	177	198	176	198	0.96
4	6	0.0031	0.2	12.1	1.7	3	23	206	227	204	227	0.95
5	6	0.00012	0.0078	16.6	0.7	1	23	240	263	240	263	0.96
6	6	0.0035	0.22	12.0	4.7	1	23	269	291	269	291	0.95

Coding Sequence: ATGGTCGAATTGGCTGTCAACATTAGCACAAAATGTGCCGAAATACACTGCGCGGCGTCAGTCGCCGAGTCAAAGTTTACAATAACCTGCATTTGCGGCATATTCATGCTCGACTTCGACGAGTTCCGGCGGCACTTTTGCAGCGACCATTTGCAGCCAAAGCTGCACAGCGAAGTAGATCAAAAATTGGACGAGCTGCACACGGAGGAGTACGGGAACGCGACGAGTGCTGGAGAGTGCCTAAAGGAGCCGCTGATGACAGCCAGTGGACATGATGCACTCACAGCCAAGGAGGGTCAGGTGGATTCCAATTGGAGCGAACTGCCGGAGCCGGGCGAGCATCGTCCGCAGAAGCCGAACACCTGCGCCTATTGTGGACGCACGTTTCGCCGGCGCTATCTGCTCGACACGCACGTGAACATCCACACGGGCAGCAAGCCGCATCAGTGCGAGCAGTGCGGCAAACAGTTCCGGGCCGTCTCCACGCTGACGCGCCACCTGCGCACGCACGAGCAGCGCCAGGCGCTGCAGTGCCGCCACTGCGACCAGCAGTTCACCCACCGCAGCGCGCTGCTCAGCCACGAGTCGCGGCACACGCAGGTCCGGCGCTGGGCCTGCGCCAGCTGCGACAAGTGCTTCTACACGCGCAACCAAATGGACACCCACGCACGCCGGCTGCATGGCTGCAGTCCCGCGCTGAGTCCGGCGCACCTGCCCTTCGCCTGCGAGCTGTGCGGCAACAGCTATCGCAGCGCCTCCACGCTTAGCACCCACCGGCTGAAGAAGCACTATCGCCTGGCCAAGCACAGTTGCGAGTGCTGCGGCAAAAGGTTCCCGGACGCCCATCGCCTGCAACAGCACCAGCTAATTCATGTCAAGCCCGCGGCCGTTGTCAAATAA
Protein Sequence: MVELAVNISTKCAEIHCAASVAESKFTITCICGIFMLDFDEFRRHFCSDHLQPKLHSEVDQKLDELHTEEYGNATSAGECLKEPLMTASGHDALTAKEGQVDSNWSELPEPGEHRPQKPNTCAYCGRTFRRRYLLDTHVNIHTGSKPHQCEQCGKQFRAVSTLTRHLRTHEQRQALQCRHCDQQFTHRSALLSHESRHTQVRRWACASCDKCFYTRNQMDTHARRLHGCSPALSPAHLPFACELCGNSYRSASTLSTHRLKKHYRLAKHSCECCGKRFPDAHRLQQHQLIHVKPAAVVK

Sequence clustering based on sequence similarity using MMseqs2