Basic Information

Insect: Drosophila buzzatii
Gene Symbol: Runx1_1
Assembly: GCA_035045845.1
Location: JAWNOS010000258.1:256814-279468[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5 2.1e+04 -8.8 6.4 59 75 178 186 150 200 0.57

2 3 1.4e-51 5.9e-48 161.9 0.0 3 94 248 339 246 346 0.97

3 3 3e-17 1.3e-13 50.9 0.1 94 129 400 435 398 435 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5	2.1e+04	-8.8	6.4	59	75	178	186	150	200	0.57
2	3	1.4e-51	5.9e-48	161.9	0.0	3	94	248	339	246	346	0.97
3	3	3e-17	1.3e-13	50.9	0.1	94	129	400	435	398	435	0.97

Sequence Information

Coding Sequence: ATGACCAGCAACAATGAAAACTCCGCCTACAAGGTCAGCGGATGCGGTCAGTCCACTCACACCCACACctctagctccagctccagctccaGTTGCACGTTCAACATTCAGCGCTGGCATGCCTCAGTGTCCTCCGTGTCCTCAGTGTCCTCAGTGTCCTCATGGACGCCATTTGTGCCCTCGCGTCGAGTGGCTCACGCTCAAGGACATCTGGAGCAGTTTGAGCAggagccgcagccgcagccgcaagCCACGCACTACACACACCATCACTTGCACCACTCACAGCAGCACCActcacaacagcagcaacagcaacagcatcagcaacagcatcatcagcatccCTACAATAACAATCCATATAgcactcagcagcagcagcatcacagcagcaacaactaccacaacaacaacaacaacaacaacaaccacaacaataacagtcacaaaatgcatttgacaACGACGAGCAGTAATTCGACGGCATCGAATGCCaattccaacaacaacaataccaacaacaacaataacaacaacaacaacacagccaacaataacaacacagccagcagcaacaacaacaacaacagcaacacaaatggctccaacaacaacaatagctccagcagcaacaacaacaacaacacagaaCAAAACACACCCCCCACACCCGCCCAGCTCTTGAACGAGGCCTACACCAAAATGACCTCCGACATATTGGCTGAGCGCACCTTGGGCGACTTCCTCACCGAACATCCCGGCGAGCTGATAAGAACCAGCAGTCCGCTCTTCGTCTGCACCGTCCTGCCGCCGCACTGGCGCTCCAACAAGACGCTGCCGGTGGCCTTCAAGGTGGTCTCCCTGGGTGACATCATGGACGGCACCATGGTCACAGTGCGCGCCGGCAACGATGAGAACTATTGCGCCGAGCTGCGCAACTGCACGGCGGTCATGAAGAATCAAGTGGCCAAGTTTAATGATCTGCGCTTCGTGGGACGCAGCGGCAGAGGAGAGGACAGAGCACAGCATAGGACCGGGCAGGAGTCGTCCAACGTCCTGCAGGGACCTGCACCAAAGTCTGTCACATGTGCCACAGAATTCATGCATTGTCATTCATTGGGCATGCCCCCAATGGACATTGGCATGTCAGCTCTTCCATCTGCTATATGCATTCGCATTGAGCcgtttaattGCAAGAGCTTCACGCTAACCATCACCGTGTCAACGAATCCACCCCATATAGCCACCTACAACAAGGCGATCAAAGTGACTGTTGATGGGCCACGCGAGCCGCGCTCCAAAACCAggcaacaacaacaattccacTTTGCATTTGGCCAGCGACCGTTCCACTTCTCGACGGATCCATTATCGGGCTTCCGCATGCCGCCGATTGGCAATTGTCAGAGTGAGTAA
Protein Sequence: MTSNNENSAYKVSGCGQSTHTHTSSSSSSSSCTFNIQRWHASVSSVSSVSSVSSWTPFVPSRRVAHAQGHLEQFEQEPQPQPQATHYTHHHLHHSQQHHSQQQQQQQHQQQHHQHPYNNNPYSTQQQQHHSSNNYHNNNNNNNNHNNNSHKMHLTTTSSNSTASNANSNNNNTNNNNNNNNNTANNNNTASSNNNNNSNTNGSNNNNSSSSNNNNNTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGEDRAQHRTGQESSNVLQGPAPKSVTCATEFMHCHSLGMPPMDIGMSALPSAICIRIEPFNCKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -