Dbur005170.1
Basic Information
- Insect
- Drosophila burlai
- Gene Symbol
- Runx1
- Assembly
- GCA_008042655.1
- Location
- VNJT01015705.1:1-6305[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5 1.9e+04 -9.9 10.2 56 78 55 77 44 85 0.70 2 2 4.8e-50 1.8e-46 157.0 0.0 4 92 107 195 104 195 0.98
Sequence Information
- Coding Sequence
- ATGCACATTTCTGCTGAGGTCAGTTCGACCACCTCAAATCAAatacagcagcaacatcagacgcagcagcagcaacatcagcaaacAACACCGACCACAACGAAGCGACGCAATGCTGagtactcctcctcctcctccaacaacaacaacaacaataccagcaccaccaacaacaataacaacaatagcaCTACgatcaacaacaataacaacacgaataataataacaataataacaataacaatgttAAAACAAAACCCGTGGACACGAGTCCTTATCTGACACCGGAGAATCTCATCGAGCGCACCGTCGACGTCCTGCTCGCCGAACATCCTGGCGAGCTGGTCAAGACGGGATCACCTCATGTGGTCTGCACCACCTTGCCCACGCACTGGCGTTCAAACAAGACCCTTCCGATCGCCTTCAAGGTCCTGGCCTTGGGCGAGGTCATGGATGGCACCATAGTGACCATTCGGGCCGGAAACGACGAAAACTTTTGCGGGGAACTAAGGAACTGCACGGCCGTAATGAAGAACCAGGTGGCCAAGTTCAACGATCTGCGATTTGTGGGCAGAAGTGGAAGGG
- Protein Sequence
- MHISAEVSSTTSNQIQQQHQTQQQQHQQTTPTTTKRRNAEYSSSSSNNNNNNTSTTNNNNNNSTTINNNNNTNNNNNNNNNNVKTKPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00484912;
- 90% Identity
- iTF_00532882; iTF_00484912;
- 80% Identity
- -