Basic Information

Gene Symbol
zfh1
Assembly
GCA_008042755.1
Location
VNKA01002194.1:123187-127447[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2.5e-05 0.0021 18.5 1.0 1 23 151 173 151 173 0.97
2 15 0.00078 0.063 13.8 1.2 3 23 181 201 179 201 0.94
3 15 0.00026 0.021 15.4 0.2 1 23 364 386 364 386 0.98
4 15 0.00013 0.01 16.3 0.8 1 23 392 414 392 414 0.98
5 15 1.3e-05 0.0011 19.4 2.3 1 23 446 468 446 468 0.97
6 15 0.0096 0.77 10.4 1.2 1 23 502 524 502 524 0.93
7 15 0.037 3 8.6 0.7 1 23 530 553 530 553 0.93
8 15 0.025 2 9.1 0.4 3 19 562 578 561 579 0.95
9 15 0.00015 0.012 16.1 5.6 1 23 588 610 588 610 0.97
10 15 0.062 5 7.9 0.4 3 23 617 637 615 637 0.96
11 15 8.7e-06 0.0007 20.0 1.0 1 23 646 668 646 668 0.98
12 15 0.00098 0.08 13.5 0.1 3 23 676 696 674 696 0.97
13 15 5.3e-05 0.0043 17.5 0.5 1 23 702 724 702 725 0.95
14 15 0.035 2.8 8.6 0.3 1 23 735 757 735 757 0.97
15 15 0.0052 0.42 11.2 0.2 1 23 1299 1321 1299 1321 0.97

Sequence Information

Coding Sequence
ATGAACAACCAGGACTATGGCGGCATCCAGTGGATACAGCACCACCCCGCTGCAGGCGACTCATCCGAGACGGACATACTGGAGCACGAAGACGCCGACGGCGATGGTTTGGTGAGAGGAGCGGACGGTGACCCAGATGGGGATGCGGATGCTGACCTGGACCATATGGCTGCCGAGAACCTGATCTTTATGGCGCGCGACGGCCAGCTGGGCGAGATTATTGCCGCCAACGAGGGCACTGTCCTGGTTACCGCCGATGGCACAACGGTGGCGTATGCGGAATCCTTTGATGACGACGCCCAAGTGGTCACCGAAGAGGTCATCACCGATGATTGGGTGCAGCACCAAGGAGCCGAGCGCGTGGAAATTGCCGCTGAGCAGATAGCTGGCATCAGTAGCTCTCAGGAACTCCTAGACATGGAGCAGGACGAGTACACGGCTTTGCGACCATATCCCTGCGACTTTTGCAGCCGACGCTTTCGAAAGAAGGCCAGCTTGAACAACCATATGCTGGCCCACCAGAACGATCGACCGCATCTCTGCAAGTTGTGCGGTGCACGCTTCTCACGCCGGGCGGAGCTTATTAGCCATTTTAAGGCCCACGCCGAAGCCCAGGATGCTGCGGATGCCgaggcagccgccgccgctgccgtttCGTCTTCCATAAAATTTGAGAATCACGGCCACAGGCAGATTGATGATCACTACTACGAGCAGGAGTGGCCCCTgtatcagcagcaacaacagcagcaggatcagcaggagcaggaacaagCGCAACATGAACAGATGCTGcaacaggagcaacagcaactagTCTGCAACAGCGAGGTCCAGTTTGTGGCCAACTACACATCAACCGTGGCTCCCCTTCCGGCTCCGTCGCGCGGTAGAATAAGCAGGCTGAAGCCCAAGGAGGAGAGCAGCCAGTTTATCGTAATTACCGATAAGCCAACGTCCAGTGAGTTGCGGGATTATGTGGAAAGTGAGTCTGTGCCTCAGCCAGTGGTGGCCATACCGCCACCCGTGGCCATTGATCCGCCGCCAGCGCCGCAGCCAAACTTCCCGGTTCTGGATGACAGCAAGCCTTTCGTGTGTCAGCAATGCGGATTGGCTTTTGCTCGGGAAAAGGCGCTAGTCTCGCACACTAAGAACCATCGCGTGGACTCTCCCTTCGAGTGCAACCAGTGCCAGGAGATGTTCTGGGACAACAGCAGCCTGCAGGATCATCAAAAGACGCATCAGTTTGAGGAGAGCAACTCTGAGTATGATCCCGCCTCAGGCGATGATAGTGCCAGTGAAACTTCGGAGCCGGAGGAGCAGCTCTACGGAGAGTTTTACTGCAACGAGTGCGGCATCTCCTTCCATCGCCAGGATCTACTGAGACGACATGCCAAACAGCATTTCAAGCAGCAGGATCAGCCTTCGACGGTGGCGGCAGGAGACGGAAGCTCTTCGGACATCATAGCTAGCGGGGATCTGGCCAAAGATGGTAGCGGCGGTCACTGTTGTCAGACATGCGGTAAATCATTTCCTAGTGCTTTGGAGATGCTTTCCCACGCCGAGATTCATGCGAGGTTTCCGCCCTTCAAGTGCGTCCTTTGCGGCATAAGTTTCTACGAGGAGCAGGCCATTAAGCGGCATCTGCATGCCCGCCATCCTAACGAACTGAAGGCCAACTCCTGCGTGCTGTGCGGCAAGGAGTGTCGCGACCGCAAGGCCCTGATCAAGCATGCCTGGGATCACTCCCGCGAAAAGTGCCACTCGTGCTCCAAATGCGGCAAAAACTTTCACAATAAGGCGCGCCTGAAGCGGCACATGGCCTCGCATCGGGACAAATCCGTGATCTGCGAGGTCTGCCAAGAGGAGTTTCCCGACGGGCGTACGCTTTCCAATCACCGTCACTCGCACAGCACCACATCACCGGGCAAATTGTTTCCCTGCCACGAATGCGGCAAGACATTCGGATCACGCAGTTCCCAGCAGATCCACGTCCGCATCCACACGGGTGAGCGACCCTACGGCTGTCGCTACTGCTGGAAGGCCTTTGCCGATGGCGGAACCTTGCGCAAGCACGAACGGATCCATACGGGCGAGAAGCCCTACGCCTGCTCCGTCTGTCCGCGCGCCTTTAATCAGCGGGTTGTACTGCGGGAGCACATCCGTTCCCACCACTCGGGATTGGACGTGACGACAAATACGTACCACTGCACGGTCTGTTCCGAAGATCTGGCCTCGTCTAATGACCTCATACAGCACCTCATCCAGCACAGTGATTCGAACACTGCCAAGCAGCGTCAACCAGTGACGGGCCCGCGAAAGTATAAGCGTCGACGAAAGCTGCAGCCGCACGAGATTGCGCACATGCGAGCGGAACACAAGGATTCCAACGGCGGAGGCGACGATGAGGAGATTCTGGGAGGCGaaggcgatggcgatggtgaGGAGTATGCCAGCGATATTGACCTTTGCGACTTTGACGTGGAGAATGTGGACGATCTATTTAATATGGCCGAGTCGTCgcccaaaaaggaaaagcgcaAGAGGTCATCGGCATTAGCATCCGTGAAGACGGAACCTAAACCAGTTTCCAATGGTGGCGCATCGTCGGCAAAGCCTGTCCGAGAGAAGAACAAGGCCAAGCTGCGATATGACTCCACCAGCAGTCAGCAATCGGATCGCATTTGGGAGGAAAAGTTTCTGCAGGACAGTCAGGTGGCGCTTTTCCAAATCGATTCGCTGGTGGTGGTCAACGATACGCATCTCCAGCCTGCGAGCTCAGCGACCATGCCCAAGACGAGAGGGGGCGCCAAGCAGACTCAGCATCAGGCGAAGCAGCCTGGCAACTCCAATCCCTCGGCTGCAAGCTCAGTTGCTACATCATCaacctccgcctccgcctccgcctccgcctctaCATCAACTTCCAGCAGTCGCAGCAGAAAGAAATCGGCAGCCGTAAAGACAGCTGCTGCCTCGCGACCTCGAATGATTCACACGGAAAAGGCCAAGGTGCCGTCCAAGGGAGCGGCCGGCGGAGAATTGGCCAAGAAGACACGCTCCAAGACCTACATCACCCGCACGGAGACGAGCAATCTGAGTAGTCTGGACAAGTCGCGCAGCAGAGCCTCTAACATCGTGGATGATTACGAAATCATTTCACCGGCTACCCATCCTCCCAACCAGATCAGTTCCAGTCCCCTGCACatcaagcaggagcaggagcagcagcatcgtgTCCAAATGATGTATGACGACAACCTTCTTATAGACGCTGCCTTGCTCCGGGAGAAGACCTTTGAAAAATTTAACCCCAGCAATGTGAACGATCTGGAGGATATTCTTCGCTCGCCGCTCAAGCACGAACGCAATTCCCGCCTGCGATTCACCAGCGAATCCTCGACCACGCCGCAGTTTCTGCCGGAAGAAGAGCAGAATTTGATTAAGATCGAGCCTACGTCTCCGGATTTGCGAGAGATGCTGGAGAGTCAGAGTCAAAGGGTCAGAGTGCCAAGTGGCAACACACCGTCTCCCTCATCATTCTCCTCCGCCAGAACTTCTCGTCATCGTATGATCACTGCCAGTGGACCGAGGACAGGGAACAAGAGATCCGctgggggaggaggagggagtgGTGACAGCGCTAGCCAATCCAACCCTGCTCCAGGAGTGGCGGCCAAGAAAGTGAGCACTGCTGCCAGCAAGGTCGGCAGTTCGTCCTCCTACCTCAATTACGGGGTGGATGCCTACAATGTGAACGGTCCTGCCAGTGCCAGCACTGCCGATGTGGGCAGCGGATTCTTCTCCATCTCGGAGGTTGTGTCGGCCGCCGATGCCGCTGATGCGGCGGCCAAGGCGGCTGCGGCTGGGAAACCGGAGCGGAAAACGCGCAGTTTCGAGTGTGAAATGTGCTCGGCCATTTTTTATGATCGAGCCCAATTACTGGAACATGTGCACATTCACATCTAG
Protein Sequence
MNNQDYGGIQWIQHHPAAGDSSETDILEHEDADGDGLVRGADGDPDGDADADLDHMAAENLIFMARDGQLGEIIAANEGTVLVTADGTTVAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAAVSSSIKFENHGHRQIDDHYYEQEWPLYQQQQQQQDQQEQEQAQHEQMLQQEQQQLVCNSEVQFVANYTSTVAPLPAPSRGRISRLKPKEESSQFIVITDKPTSSELRDYVESESVPQPVVAIPPPVAIDPPPAPQPNFPVLDDSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNSSLQDHQKTHQFEESNSEYDPASGDDSASETSEPEEQLYGEFYCNECGISFHRQDLLRRHAKQHFKQQDQPSTVAAGDGSSSDIIASGDLAKDGSGGHCCQTCGKSFPSALEMLSHAEIHARFPPFKCVLCGISFYEEQAIKRHLHARHPNELKANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVICEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVTTNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAEHKDSNGGGDDEEILGGEGDGDGEEYASDIDLCDFDVENVDDLFNMAESSPKKEKRKRSSALASVKTEPKPVSNGGASSAKPVREKNKAKLRYDSTSSQQSDRIWEEKFLQDSQVALFQIDSLVVVNDTHLQPASSATMPKTRGGAKQTQHQAKQPGNSNPSAASSVATSSTSASASASASTSTSSSRSRKKSAAVKTAAASRPRMIHTEKAKVPSKGAAGGELAKKTRSKTYITRTETSNLSSLDKSRSRASNIVDDYEIISPATHPPNQISSSPLHIKQEQEQQHRVQMMYDDNLLIDAALLREKTFEKFNPSNVNDLEDILRSPLKHERNSRLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMLESQSQRVRVPSGNTPSPSSFSSARTSRHRMITASGPRTGNKRSAGGGGGSGDSASQSNPAPGVAAKKVSTAASKVGSSSSYLNYGVDAYNVNGPASASTADVGSGFFSISEVVSAADAADAAAKAAAAGKPERKTRSFECEMCSAIFYDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00480304;
90% Identity
iTF_00617778;
80% Identity
-