Basic Information

Insect: Drosophila bifasciata
Gene Symbol: zfh1
Assembly: GCA_009664405.1
Location: CM019044.1:1212112-1236527[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0024 0.16 12.2 1.9 2 23 76 98 75 98 0.95

2 9 0.0018 0.12 12.7 0.1 1 23 310 332 310 332 0.96

3 9 9.6e-05 0.0064 16.6 1.7 2 23 348 369 347 369 0.97

4 9 4.7e-06 0.00031 20.8 6.3 1 23 378 400 378 400 0.99

5 9 0.00028 0.018 15.2 1.2 3 21 408 426 406 427 0.94

6 9 0.0078 0.52 10.6 1.8 2 21 643 662 642 663 0.92

7 9 1.2e-05 0.00083 19.4 0.5 1 23 1028 1050 1028 1050 0.94

8 9 4.6e-05 0.0031 17.6 7.4 1 23 1056 1078 1056 1078 0.98

9 9 0.0023 0.15 12.3 4.3 1 21 1084 1104 1084 1105 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0024	0.16	12.2	1.9	2	23	76	98	75	98	0.95
2	9	0.0018	0.12	12.7	0.1	1	23	310	332	310	332	0.96
3	9	9.6e-05	0.0064	16.6	1.7	2	23	348	369	347	369	0.97
4	9	4.7e-06	0.00031	20.8	6.3	1	23	378	400	378	400	0.99
5	9	0.00028	0.018	15.2	1.2	3	21	408	426	406	427	0.94
6	9	0.0078	0.52	10.6	1.8	2	21	643	662	642	663	0.92
7	9	1.2e-05	0.00083	19.4	0.5	1	23	1028	1050	1028	1050	0.94
8	9	4.6e-05	0.0031	17.6	7.4	1	23	1056	1078	1056	1078	0.98
9	9	0.0023	0.15	12.3	4.3	1	21	1084	1104	1084	1105	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTACACGTTTTGGCCAAGAGGATAACAGCATAATAATACAGCAGAGCATGCCATCGTCCACAGCCTTTACAATGCAGTTTCCCTCTTTGGCTTCCAGTCTGCACCACCATCAGGCACCGCACAGCAAGCCCAGCAATGGCTCTGGTGTTAGCCAGGAGCAGCACGTACAGCCAGGTGTATCCGTCGATGATTTCCTGGTCAAGTGCACCCAGTGCCACAAACGCTTTACAGAGTTTCAGTCCCTCAGCGAACACATTGCCAGCGAGCATCCGCACGATAAGCTGAACTTTGAGGCAAGTCGCGGCTCCAGTGGTGCAGCTGTGCAGCCGGAGAGCGATGCCGACGAGGATGAGCAGAGCAATCTGAGTGGCAGCCGCTATGCCAAGTCCCCAGCAACCACCAACACCCATGCTGCcccaagcaacaacaacaacaacaacagcgatctggccaagaaccacaacaacaacagcaacagcagtaagCACTCGCCCATGTGCTCACCCGGATCGGCGGGTGGTCCCGCCGCAGATCTCTTTGCCCACCTCTCACACGGAGCACCGCCGCAGCTGCCCGCCCACCTGCACGCCCAGTTcatggccgccgccgccctgGCCATGCAGTCCGCACGCTCTGTCAGCTCATCCGCCAGTTCGCCCAACAgtcatcaccagcagcagcagtcgcaccatcaccaccagcagcaacaccaacaccagctccaccaacagcaacagtcgcaacagcagcagcagcagttggccctacagcagctgctgccgccacAGCTGCCgggcagcaatagcagcagcgtGGGCAGCAATTCTGCCTACGATCTTGATCTGAGCGCGCCACGCTCCACCTCCAGTCCGGGCTCCACCACAGGCGACCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCgcgagcagctggagcagcacgAGCTCCTGCACTCGCCCACCGGGGCCCACCAGCCCACGGCACAGAATGTCTCTCAGACCTGCCGAATCTGCCACAAAGCCTTCGCGAATGTGTACCGCCTGCAACGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGAAAATTCAAGTGCAAGGAATGCGACAAGGCATTCAAATTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCATTCGGCTGCGACAACTGCGGCAAGCGTTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTGAAGCGGCTGGAGAAGAGTCCCTGCAGCGGGCCCCCCCGACGCTCGCCCACGGACCTGCTGCAGGGCCCCAAAACGGCGGCGCAGGCTGCGGCTGCAAATGGAGCTCCTCCACCGTTCTACCCGAATTACATGAATGCGGCTCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGATCCCCGCGTGCACCCCTACAGCATACAGCGGCTCCTGGAGCTGACAGCCgccggacagcagcagcagcgcgaggaacgcgaggagcaggagcagcacgaAGAGCGTCCTGCGACGCCGGAGGAGCCCAAGCTGGTCATGGACATCGATGAGGCTGAGGCCAAGGAGCGTATAGTGCCACAGGCGGTGAGCCCGCAAACCATGTCAGAGGAGGTCGCCATGGCCACTGCTCCCATCAAGCAAGAGCCCAGCCGCGAGCCCACCCCTCTCCCGGAGAGTGCACCACCCTCTCCCCAGGCCTtcaagcaggagcaggaggagcccCGTTCCCTTGAGGAAGATCAGCCCATGGAATCGGCTCAACCCGaaccctctgcctctgcctcctccCCCAGGAACACACCCGTCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAATCACCACACAGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATCAAGGAGGAACTGGAGCAGCActaccaccagcagcaacagcagcagcagcatcaacagatccagcagcagcaacagcagcaggcatccTTTGCACTGCCCTCGGCCAGCGAGGatgacgacgaggaggaggagcgtgagaatgacaacgacaacgacacgGAGCAGCGTCCAGACAGCAACGAGCGCAAGGTGCGCGTCCGCACGGCCATcaacgaggagcagcagcagcagctgaagcagcACTACGCCCTCAATGCGCGTCCGAGTCGCGACGAGTTCCGGATGATTGCGGCCCGCCTTCAGCTGGATCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAACCGTTCACGCGAGCGGAAAATGCAGAGCTATGCGAGTGTCCACTCCCAGGCAGCTCCAGCCGCCAATGAGGTGCCCAATACGCCGGTGGCCAGCCGTCCCACAACCGAGGATCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCTTGACGCCCAAGAGCGATCACTCTGCCGTGTACGGAATGCCCCAGCAGCAGGCTGCCGGACAGCCAACACCCGCCGACTTCCAGGAGGCCATAAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCTTCGGGCGCCTCTCTGCAGCAATCCTCGGCAGCTGCGGCCGCTGCTGCGGCAGCCCTCTGGCCCTTTGGGGGTCCGCCTCCATCGCCGCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCcgcgcggcggcggcggccaggCCTTCCCTGGGCTCCAGTACATGCTGCCAATGCAGCGGCTACCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCGCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTTCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGATGACTTTGGCAACGGCCTGATGCCGCCCAAGGCACGCCGCGTCAAGGCAGAGACCCACGGGCATGCCGGTGATCCGGATCTCCCATTCGTATGTGACCAGTGCGACAAGGCGTTTGCCAAGCAGAGCTCTCTGGCGAGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGATTGCCCAAAGGCCTTCAAGCACAAGCATCACCTGACGGAGCACAAGCGTCTGCATAGCGGGGAGAAGCCCTTCCAGTGCTCCAAGTGCCTGAAACGCTTCTCGCACTCGGGTAGCTATAGCCAGCACATGAACCACCGGTACTCCTACTGCAAGCCATACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNSIIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKPSNGSGVSQEQHVQPGVSVDDFLVKCTQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAAVQPESDADEDEQSNLSGSRYAKSPATTNTHAAPSNNNNNNSDLAKNHNNNSNSSKHSPMCSPGSAGGPAADLFAHLSHGAPPQLPAHLHAQFMAAAALAMQSARSVSSSASSPNSHHQQQQSHHHHQQQHQHQLHQQQQSQQQQQQLALQQLLPPQLPGSNSSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGAHQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPCSGPPRRSPTDLLQGPKTAAQAAAANGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQREEREEQEQHEERPATPEEPKLVMDIDEAEAKERIVPQAVSPQTMSEEVAMATAPIKQEPSREPTPLPESAPPSPQAFKQEQEEPRSLEEDQPMESAQPEPSASASSPRNTPVELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHQQIQQQQQQQASFALPSASEDDDEEEERENDNDNDTEQRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYASVHSQAAPAANEVPNTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAVYGMPQQQAAGQPTPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQHEATPAQHCSTPRGGGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKARRVKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00487196;