Basic Information

Gene Symbol
topi
Assembly
GCA_009664405.1
Location
CM019044.1:10961550-10964227[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 4.2e-06 0.00028 20.9 0.6 2 23 224 245 224 245 0.97
2 10 0.13 8.8 6.8 2.8 2 23 272 293 271 293 0.88
3 10 0.16 11 6.5 0.0 2 23 360 381 359 381 0.90
4 10 0.00019 0.013 15.7 0.5 1 21 428 448 428 452 0.90
5 10 0.0055 0.37 11.1 0.2 2 23 467 489 466 491 0.89
6 10 7.5e-07 5e-05 23.3 1.9 1 23 514 536 514 536 0.95
7 10 0.0017 0.11 12.7 1.0 1 23 542 567 542 567 0.94
8 10 0.37 25 5.3 1.7 1 23 573 595 573 595 0.88
9 10 3.2e-08 2.1e-06 27.6 0.4 1 23 601 623 601 623 0.99
10 10 0.0014 0.096 12.9 2.0 1 23 629 652 629 652 0.96

Sequence Information

Coding Sequence
ATGGATGACGACAGTTTTAGGAGCTTTGAGCTCAACGAAGTATCCGGGGAGTACACCCTGGCAGAGATCGAAGTTGGCGACGAGGTGCAGCTGAATTTCAGCCACCTGCCGGGTGCCACAGTGCTGGCATCCAGCGAGGAAAACGGCCAAACACAGCGATTTCTCGGCCAGGATGAACTGGTCCAGTTCTTTGCCAGGGCACCGGCACCCATTATGCAAATGTCCACTGAGGCGGTGCTGCAGCGCACTCTGGAGCATCCAGCGCTGAAGCAGATACTCCAGGAAGCCGATGGCCAGCCGGATTTTGATCCGGCAGCAGAGCAAATGAAAATTCGCGAATTCTTAGCGGGCGTTACAAACAATAAGATGACCACAGAGGAGTCAGTCTTTCAAGCACAACGCATGAGCGCGTCCTCGACTGGGTCACGCATCTACAAGTGCCAGGACGCCGTGAAGCCCGTCTGTGAGGCAGCTGCTCAGCAGGATAAGCCGCGAACAGCGAAGGCGTCGACGGGAACCATTCCAGCGGTGCGTTATATTCGAGGCAGCGAGCGCATCATCTTGGAAAATCAAATACGACTTCGGCGCTACATGAAGGACGAGCTGAAGTACGATGTCACCACGGGCATGGACAATTCGATGGCCAGGAAGACGGGCAAGCAGCCCAACGAGTGTACTATATGCGATCGGCAGTTCGTGCATCCCTCCGGCCTGGTGCGCCACATGGAGAAGCATGCCCTGAACCTGATCGCCCCACAGGCGAATGCGCCATCGAGCCCGCCTACGCCTGCCCCCGGCCTGGCTGTGGTGATAAAGTGCAACGACTGTGGCCGCATCTTCTATGATTGCAAGCTGGCCATGTGCCATGTCCGTGTGCATTATCCCGAAAAACCAAAGTTGTGCGAACCCCTCACGGACGAGAACGAATCGGAAAAGAAAGAGTTCATTAAGCGCATGCAGAAGGGGGAGTTGCTCTTCCTATATGTGCACTCAAAGAAACGAAGCTTCGACCAGAAGCAGGCGAAGCGAGCATTGGAGGCCGGGCTATTTTCTACCCTGATCCTGGGTTCCGTGTTGCAGTGCGAGTTCTGCGAGTTCGTATTTGCGGATATTGAGAAGCTGCTCGTCCACTCGGCCGCTCACGTGGTGGAGAGGCGCTTCGGGTGCACCGCCTGCGGCATTACGATGAACACGGCCAAGGAGGCCAGTATCCACTTCCAGACGGATTGCATCTTCATGCGCGAAGAACTCAAGCGGCTGGATGTATCTCTCTTTCGATACTTTGTGTGCAATGTGTGCGAGCAGAAGTTTTCCACCGCCGACCTGCTGCAGGAGCACCGATACATCTACTACCACTACTTTCCACGTCTCAACGCAGAAGGGagtgcgctgctgctgccctgcgaGTATTGCGATATCAATTTCACACAGGCTCACGAGGTGGAGGCGCACAACCTGGAAAAGCATCTGAACAAGAAGAGGCGCGAAAAGGAGACGCGAAGCAGCGGCCCCGGCCACGGCAACGGCCGCCTTCGCCAGTACCTGTGCGACGTTTGTGGAAAGTCGTACACCCAGTCAAGTCATCTGTGGCAGCACTTGCGCTTCCACCAGGGTGTCAAGCCCTTTGCCTGCCAAGAAGCTAACTGCGATAGAAAGTTCACCATTCGTCCGGACCTCAACGATCACATTCGGAAGTGCCACACTGGAGAGCGACCGTATCATTGTCTGGTGTGTGGCAAGCGCTTCCTCACCGGATCCGTCTTCTATCAGCACCGTCTGATACATCGCGGGGAGCGGCGCTACGAATGCGATGAGTGCGGCAAGCGGTTCTACCGGGCCGATGCCCTGAAGAACCATCAGCGGATCCACACTGGCGAGAAGCCGTACAGCTGCCTCTTCTGCACCAAGACCTTCCGGCAGCGCGGCGACCGGGACAAGCACATACGTGCACGACACTCCCATTTGGACGCCAATTCGCGGCTCATGATGCAGATGCAGAAGTTCCAGCTAGAGTCGGCTGAAGCATTAAAGGCCAGACACCGGCATGAGCAAATGGGAGATGGTGACAGCTACACGGCTGAAGCATTAGTCGCTCCTGAGGAAGATGGTGCAATTAAATTAGTTGCGGAAGAACAAGACGGAATATATTGCGAGACAATTGACGGATTCAACCCAAACGACTTTGAGATGCAGCAGTGTGTGGAGGAGACTGAAAGCACACCTATGAATGAAGACGAAAATCAAGAAGTTATTCTGTACGTGAACCCAGAGCTAGAGCCGACTATGACAATGTCTTATGAACCGGAAACAGAAGAAACACAGAAAATTGAACAGGAGATTCCAGTGAAACCCGAAAGGCCAAAGCGTAAGATTGTGGTGGTGAAGAATAATCCATCTCTACCGCGTTACCCAAATTCATACATTTAA
Protein Sequence
MDDDSFRSFELNEVSGEYTLAEIEVGDEVQLNFSHLPGATVLASSEENGQTQRFLGQDELVQFFARAPAPIMQMSTEAVLQRTLEHPALKQILQEADGQPDFDPAAEQMKIREFLAGVTNNKMTTEESVFQAQRMSASSTGSRIYKCQDAVKPVCEAAAQQDKPRTAKASTGTIPAVRYIRGSERIILENQIRLRRYMKDELKYDVTTGMDNSMARKTGKQPNECTICDRQFVHPSGLVRHMEKHALNLIAPQANAPSSPPTPAPGLAVVIKCNDCGRIFYDCKLAMCHVRVHYPEKPKLCEPLTDENESEKKEFIKRMQKGELLFLYVHSKKRSFDQKQAKRALEAGLFSTLILGSVLQCEFCEFVFADIEKLLVHSAAHVVERRFGCTACGITMNTAKEASIHFQTDCIFMREELKRLDVSLFRYFVCNVCEQKFSTADLLQEHRYIYYHYFPRLNAEGSALLLPCEYCDINFTQAHEVEAHNLEKHLNKKRREKETRSSGPGHGNGRLRQYLCDVCGKSYTQSSHLWQHLRFHQGVKPFACQEANCDRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAEALKARHRHEQMGDGDSYTAEALVAPEEDGAIKLVAEEQDGIYCETIDGFNPNDFEMQQCVEETESTPMNEDENQEVILYVNPELEPTMTMSYEPETEETQKIEQEIPVKPERPKRKIVVVKNNPSLPRYPNSYI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00611511;
90% Identity
-
80% Identity
-