Dbif014405.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila bifasciata
Gene Symbol
run
Assembly
GCA_009664405.1
Location
CM019041.1:37280528-37282178[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.9e-72 1.7e-68 227.8 0.0 2 129 13 140 12 140 0.99
2 2 1.3 3.1e+03 -2.6 0.0 16 66 396 446 391 459 0.67

Sequence Information

Coding Sequence
ATGCCCAGCTCAATGACGGACATGTTTGCCAGCCTGCACGAGATGCTGCAGGAATATCACGGCGAACTGGCCCAGACGGGCTCCCCCTCGATATTGTGCAGTGCGCTGCCCAATCATTGGCGCTCCAACAAGTCGCTGCCGGGCGCCTTCAAGGTGATCGCTCTGGATGATGTGCCCGACGGCACTCTGGTGTCGATCAAGTGTGGCAACGATGAGAACTACTGCGGTGAGCTGCGCAACTGCACCACCACCATGAAGAATCAGGTGGCCAAATTCAATGATCTGCGCTTCGTGGGACGCTCCGGCAGGGGCAAATCCTTCACGCTGACCATCACCATTGCCACATATCCGGTGCAGATAGCCAGCTACAGCAAGGCCATCAAAGTGACCGTCGATGGGCCACGGGAGCCAAGAAGTAAGCAAAGCTATGGCTATCCACATCCCGGCGCCTTCAATCCCTTCATGCTGAATCCCGCCTGGCTGGACGCCGCCTACATGACATACGGCTATGCGGACTACTTCCGCCATCAGGCCGCCGCCCAGGCCGCGGTCCACCATCCGGCCCTGTCCAAGGCCTCACCCTCGAGCAGCTCCAGCATTGTGTCGCCCAGCGGCGCCAGTGCGGCGGCCTCCAGTGGtggtgctgccactgccagtggcGCTGCCGGACCCGCCGACTATCATCATGTGTCGCAGATCACGCCGCCGCCGTcgggcgcagcagcagcagcgggcgcTGGCCAACCGGCCGCCATGATGCCCTCGCCACCGGGCGCCGCACCGGCCGCCGCCTATGCCATGCCCCAGTTCCCGTTCAATCAtgtggccgccgccgccgcagcagccgcccagcagcagcagcatcatgcCAAGTCGACGCCCCATGCCTTCCATCCGTACAACTTTGCCGCCGCCGCGGGTCTGCGCGCGCGCAATGCGGCAGCGGCTGTCCTGCACCATGGCGGCGGAGACGCCACCGGCCACATCACCGGCCACATCAGTCCAGCCTCGTCGCGCCCCTCCAGCTCCTCGCCCACGCAGCAGCACGTACTGCTCAAGCTGAACACCTCCATCGAGACGAGCTCCATCCACGAGCAGTCCGCCTCCGATGCCGACTCCGATGACGAGCAGATCGATGTGGTCAAGTCCGAGTACGATCTGGACAAGTCCATCGACTCCAGCCGCAGCTCACCGCTCGCCCAGCACATTGCCGTGCCCCTTCGCATGCGCTGCGACCTCAAGGCGCCCTCCGCCCTCAAGCCCCTGTTCCACGAGAGTGCGACGGCAGCTACGGCAGCCACACGTCAGGCATCGCCAGAGACCACACTGCCGGCGGCCACCAAACTAAAGAATGCCGCTGTACAGCAAAAGACAGTCTGGCGACCATACTAA
Protein Sequence
MPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAVHHPALSKASPSSSSSIVSPSGASAAASSGGAATASGAAGPADYHHVSQITPPPSGAAAAAGAGQPAAMMPSPPGAAPAAAYAMPQFPFNHVAAAAAAAAQQQQHHAKSTPHAFHPYNFAAAAGLRARNAAAAVLHHGGGDATGHITGHISPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQSASDADSDDEQIDVVKSEYDLDKSIDSSRSSPLAQHIAVPLRMRCDLKAPSALKPLFHESATAATAATRQASPETTLPAATKLKNAAVQQKTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00471386;
90% Identity
iTF_00480657; iTF_00611173; iTF_00514667; iTF_00603126; iTF_00474284; iTF_00517488; iTF_00563673; iTF_00471386; iTF_00574587; iTF_00580471; iTF_00484221; iTF_00600832;
80% Identity
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