Basic Information

Insect: Drosophila basisetae
Gene Symbol: NFYC
Assembly: GCA_035041595.1
Location: JAWNLB010000114.1:1323156-1325885[+]

Transcription Factor Domain

TF Family: NF-YC
Domain: NF-YC domain
PFAM: AnimalTFDB
TF Group: Other Alpha-Helix Group
Description: Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) [1]. CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding. The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF. The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' [2], seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.8e-51 1.4e-47 162.3 0.0 18 128 138 248 126 292 0.93

2 5 2 1.6e+04 -14.9 35.5 153 229 360 437 343 441 0.84

3 5 0.45 3.6e+03 -3.0 55.9 141 254 404 526 396 528 0.62

4 5 2 1.6e+04 -19.1 47.4 156 225 528 598 525 609 0.71

5 5 0.31 2.5e+03 -2.5 0.8 206 217 647 658 624 665 0.53

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.8e-51	1.4e-47	162.3	0.0	18	128	138	248	126	292	0.93
2	5	2	1.6e+04	-14.9	35.5	153	229	360	437	343	441	0.84
3	5	0.45	3.6e+03	-3.0	55.9	141	254	404	526	396	528	0.62
4	5	2	1.6e+04	-19.1	47.4	156	225	528	598	525	609	0.71
5	5	0.31	2.5e+03	-2.5	0.8	206	217	647	658	624	665	0.53

Sequence Information

Coding Sequence: ATGGCTATGTACGCCACCAACAATGGCAGCACAAATAAGGCGCCAAATAGCAATGCAACAACGATGTTTGACAACACAATAACCGTAACGCCAATCAAAATGGAGCTCAGCGATGCTCTGGCCAAGCCGACGGGAGCTGGAGCAACGCCGTCGCTGCGTCGGCCAAATGCCGTTATTGTCACCACACAGCAGCTGGCAATGCCCAATGCAATGCACTCGctgacaaacagcagcaacaatagcaacaacaacggcagcaacactGGCAGTGggagtggcagcagcaactctaGTGCCATCTATACGGGCATCAGTGTGACGTCCATGTCAACAGTGGCGACGGCGGCATCGGCGCCCAAGGAGAAGGCAACCAAAGCGACCAGAGTTCAAGTGGCACGCAAACCGCCGCCGACCATTGACAACTTTTGGCCAAACATATTGGGCGAAGTGAACGGGATTGGTCAGGTGGATGCCAAGCATCAGGTATTACCTCTGGCGCGCATCAAGAAGATCATGAAACTGGACGAGAATGCCAAAATGATAGCTGGCGAGGCGCCGCTGCTGTTTGCGAAAGCCTGCGAATATTTCATCCAGGAGCTGACGATGCGCGCCTGGGTCCACACCGAGGAGAGTCGTCGTCGAACGTTGCAGCGTTCGGATATTGCTCAGGCGATTGCCAACTATGATCAATTTGACTTCCTTATCGACATTGTGCCGCGCGAGGAAATCAAACCGTCGACATCATCAACGCAGAAAACCAAAGAGCCATCCAGCTCAGGTGTGACAACAACATCCTCGtcgaatgctgctgctcctgctaatgctggtgctgctgttggcaacgCTGTTGCTGTGCCGACAGCAACTGCTGTTGTTAGCAATACAAACctgaacaacatcaacaacattagcaacaacatcaacaacatgtCCAGCGTCAATTTTACAACGAACAATCTACTAGCTGGCGCCAATGtacctgctgctgccgccgctgctgcaactggCCTCAAGCTGGATGCGGCAACGGCCGAGGTGCTCGGCTTTGGCACCGTCACACCGGATCTGTTTGCGGCAGCCCAAGTCGCTAGTAGTAAtcaccagcagctgcagcagctcaccgcccaacagcagcatcatcagccgCAGCAATTGCAGATCATACAGCAGGGAGCCGGTGGccagcaattgcaatattttattgcccTGCCTAACCAACAGCCTACTCAGCTAGTGCAGCAAAtccatcaacatcagcagcaacaacatcagcaacagcaacagctcgGCTTAAATATTGTTGCACAGCAGCCGACACAGCAGCTAATCCTCACCGCCGGACCCAATGGCCAGTTGACAGCGACGCCGGCGCCGACAAcagcccaacagcagcaaacggCGCTGCTTCAGAATCTGgcacagcaacatcagcaacaacaacaacagcaacagcagcagcaacaacaacagcagcagcagcaaatccaACTGATCCAGCAGGTTGTCACACCTAACGGCGAGCTGACCAACGTGCCCATTGCGATAAATGCGAatcagttgcatttgctgcgtctgcagatgcaacagcagcaacaacagcagcagcagcaacagcagcaacagcagcaggtgaTTATCCCAACGCAATTGTTAACCGCACAGCAGATATTGCAATTGGGCGGCAcgccaacaaatgcaacaactgtgacacagcagcagatgcaactgcaccaacaacaacatcagcagcagcagcagcagcatcaacagcagcagcagcaacatcatcatcatcagcatatACACATAACCACCAACCCAAATCCAAATAgcagcaatgccaacaacacaatcagcagcagcagcagcagcaacaacaataacaacaacggcaacaacagcaacacatcGTCCATATTCATAAATACGGCGTCGAACGCCCAAGTTGCGACGCaggctcaacaacaacaatcgcaggGAATGGCAACATTAGGCAACGATCGCAGCTTCCGGTAA
Protein Sequence: MAMYATNNGSTNKAPNSNATTMFDNTITVTPIKMELSDALAKPTGAGATPSLRRPNAVIVTTQQLAMPNAMHSLTNSSNNSNNNGSNTGSGSGSSNSSAIYTGISVTSMSTVATAASAPKEKATKATRVQVARKPPPTIDNFWPNILGEVNGIGQVDAKHQVLPLARIKKIMKLDENAKMIAGEAPLLFAKACEYFIQELTMRAWVHTEESRRRTLQRSDIAQAIANYDQFDFLIDIVPREEIKPSTSSTQKTKEPSSSGVTTTSSSNAAAPANAGAAVGNAVAVPTATAVVSNTNLNNINNISNNINNMSSVNFTTNNLLAGANVPAAAAAAATGLKLDAATAEVLGFGTVTPDLFAAAQVASSNHQQLQQLTAQQQHHQPQQLQIIQQGAGGQQLQYFIALPNQQPTQLVQQIHQHQQQQHQQQQQLGLNIVAQQPTQQLILTAGPNGQLTATPAPTTAQQQQTALLQNLAQQHQQQQQQQQQQQQQQQQQQIQLIQQVVTPNGELTNVPIAINANQLHLLRLQMQQQQQQQQQQQQQQQQVIIPTQLLTAQQILQLGGTPTNATTVTQQQMQLHQQQHQQQQQQHQQQQQQHHHHQHIHITTNPNPNSSNANNTISSSSSSNNNNNNGNNSNTSSIFINTASNAQVATQAQQQQSQGMATLGNDRSFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00501788;
90% Identity: iTF_00557193;
80% Identity: -